Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR505 Gene

Subcategory (RNA class) for MIR505 Gene


Quality Score for this RNA gene is


Aliases for MIR505 Gene

  • MicroRNA 505 2 3 5
  • Hsa-Mir-505 3
  • Mir-505 3
  • MIRN505 3

External Ids for MIR505 Gene

Previous HGNC Symbols for MIR505 Gene

  • MIRN505

Previous GeneCards Identifiers for MIR505 Gene

  • GC0XM138834
  • GC0XM139006

Summaries for MIR505 Gene

Entrez Gene Summary for MIR505 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR505 Gene

MIR505 (MicroRNA 505) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR505 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR505 Gene

Genomics for MIR505 Gene

GeneHancer (GH) Regulatory Elements for MIR505 Gene

Promoters and enhancers for MIR505 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI139890 Enhancer 0.9 Ensembl ENCODE 12.5 +33.1 33121 1.5 JUN ZNF7 FOSL1 CTBP1 GATA3 ZSCAN5C FOSL2 FOS PRDM10 SMARCE1 MIR505 GC0XP139894 RNU6ATAC23P ATP11C
GH0XI139930 Promoter/Enhancer 1.4 Ensembl ENCODE 0.4 -8.5 -8487 3.8 ARID4B SIN3A DMAP1 YY1 ZNF121 POLR2B ZNF143 SP3 REST MBD2 ATP11C GC0XM139933 GC0XM139926 MIR505
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR505 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR505 Gene

Genomic Locations for MIR505 Gene
84 bases
Minus strand

Genomic View for MIR505 Gene

Genes around MIR505 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR505 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR505 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR505 Gene

Proteins for MIR505 Gene

Post-translational modifications for MIR505 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR505 Gene

Domains & Families for MIR505 Gene

Gene Families for MIR505 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR505: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR505 Gene

Function for MIR505 Gene

Gene Ontology (GO) - Molecular Function for MIR505 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25449503
genes like me logo Genes that share ontologies with MIR505: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR505 Gene

Localization for MIR505 Gene

Gene Ontology (GO) - Cellular Components for MIR505 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR505: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR505 Gene

Pathways & Interactions for MIR505 Gene

SuperPathways for MIR505 Gene

No Data Available

Interacting Proteins for MIR505 Gene

Gene Ontology (GO) - Biological Process for MIR505 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis IDA 25449503
GO:0035195 gene silencing by miRNA IDA 25449503
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 25449503
genes like me logo Genes that share ontologies with MIR505: view

No data available for Pathways by source and SIGNOR curated interactions for MIR505 Gene

Drugs & Compounds for MIR505 Gene

No Compound Related Data Available

Transcripts for MIR505 Gene

mRNA/cDNA for MIR505 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR505 Gene

No ASD Table

Relevant External Links for MIR505 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR505 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR505 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR505 Gene:

genes like me logo Genes that share expression patterns with MIR505: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR505 Gene

Orthologs for MIR505 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR505 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia cfa-mir-505 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-505 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-505 34
  • 91 (a)
(Mus musculus)
Mammalia Mir505 34
  • 90 (a)
Species where no ortholog for MIR505 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR505 Gene

Gene Tree for MIR505 (if available)
Gene Tree for MIR505 (if available)

Paralogs for MIR505 Gene

No data available for Paralogs for MIR505 Gene

Variants for MIR505 Gene

Sequence variations from dbSNP and Humsavar for MIR505 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000058270 -- 139,924,787(-) T/G upstream_transcript_variant
rs1001191676 -- 139,923,958(-) TTTTTTTTTT/TTTTTTTTT downstream_transcript_variant
rs1001245125 -- 139,923,746(-) T/C downstream_transcript_variant
rs1001628020 -- 139,925,495(-) C/G upstream_transcript_variant
rs1008315082 -- 139,924,357(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR505 Gene

Variant ID Type Subtype PubMed ID
esv3577426 CNV gain 25503493

Additional Variant Information for MIR505 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR505 Gene

Disorders for MIR505 Gene

Additional Disease Information for MIR505

No disorders were found for MIR505 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR505 Gene

Publications for MIR505 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  2. MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α. (PMID: 26832151) Chen S … Zhao Y (Molecular cancer 2016) 3 58
  3. MicroRNA-505 suppresses proliferation and invasion in hepatoma cells by directly targeting high-mobility group box 1. (PMID: 27259809) Lu L … Yang Q (Life sciences 2016) 3 58
  4. Association between functional PSMD10 Rs111638916 variant regulated by MiR-505 and gastric cancer risk in a Chinese population. (PMID: 26394032) Liu Y … Ling Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015) 3 58
  5. A circulating microrna profile is associated with late-stage neovascular age-related macular degeneration. (PMID: 25203061) Grassmann F … Weber BH (PloS one 2014) 3 58

Products for MIR505 Gene

Sources for MIR505 Gene

Loading form....