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Aliases for MIR504 Gene

Subcategory (RNA class) for MIR504 Gene


Quality Score for this RNA gene is


Aliases for MIR504 Gene

  • MicroRNA 504 2 3 5
  • Hsa-Mir-504 3
  • Mir-504 3
  • MIRN504 3

External Ids for MIR504 Gene

Previous HGNC Symbols for MIR504 Gene

  • MIRN504

Previous GeneCards Identifiers for MIR504 Gene

  • GC0XM137578
  • GC0XM137749

Summaries for MIR504 Gene

Entrez Gene Summary for MIR504 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR504 Gene

MIR504 (MicroRNA 504) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR504 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR504 Gene

Genomics for MIR504 Gene

GeneHancer (GH) Regulatory Elements for MIR504 Gene

Promoters and enhancers for MIR504 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI138710 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 12.5 -43.8 -43792 2.9 CTCF ZNF777 INSM2 MZF1 ZNF76 ZNF2 RAD21 ZNF335 GLIS2 ZNF316 FGF13-AS1 FGF13 MIR504 GC0XM138741 GC0XP138598
GH0XI138692 Enhancer 0.2 ENCODE 13.6 -25.0 -24975 0.8 MIR504 FGF13-AS1 GC0XM138668 GC0XP138598 FGF13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR504 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR504 Gene

Genomic Locations for MIR504 Gene
83 bases
Minus strand

Genomic View for MIR504 Gene

Genes around MIR504 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR504 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR504 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR504 Gene

Proteins for MIR504 Gene

Post-translational modifications for MIR504 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR504 Gene

Domains & Families for MIR504 Gene

Gene Families for MIR504 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR504: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR504 Gene

Function for MIR504 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR504 Gene

Localization for MIR504 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR504 Gene

Pathways & Interactions for MIR504 Gene

SuperPathways for MIR504 Gene

No Data Available

Interacting Proteins for MIR504 Gene

Gene Ontology (GO) - Biological Process for MIR504 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR504 Gene

Drugs & Compounds for MIR504 Gene

No Compound Related Data Available

Transcripts for MIR504 Gene

mRNA/cDNA for MIR504 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR504 Gene

No ASD Table

Relevant External Links for MIR504 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR504 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR504 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR504 Gene

Orthologs for MIR504 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR504 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-504 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-504 34
  • 98 (a)
(Bos Taurus)
Mammalia bta-mir-504 34
  • 96 (a)
(Mus musculus)
Mammalia Mir504 34
  • 95 (a)
Species where no ortholog for MIR504 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR504 Gene

Gene Tree for MIR504 (if available)
Gene Tree for MIR504 (if available)

Paralogs for MIR504 Gene

No data available for Paralogs for MIR504 Gene

Variants for MIR504 Gene

Sequence variations from dbSNP and Humsavar for MIR504 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002307671 -- 138,668,737(-) A/G upstream_transcript_variant
rs1002887827 -- 138,667,951(-) C/G upstream_transcript_variant
rs1003247488 -- 138,668,398(-) C/T upstream_transcript_variant
rs1006976210 -- 138,669,169(-) G/C upstream_transcript_variant
rs1007926450 -- 138,667,282(-) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR504 Gene

Variant ID Type Subtype PubMed ID
nsv525867 CNV gain 19592680

Additional Variant Information for MIR504 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR504 Gene

Disorders for MIR504 Gene

Additional Disease Information for MIR504

No disorders were found for MIR504 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR504 Gene

Publications for MIR504 Gene

  1. A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma. (PMID: 26854715) Cui R … Wang Y (Cancer letters 2016) 3 58
  2. Downregulation of microRNA-504 is associated with poor prognosis in high-grade glioma. (PMID: 25755767) Guan Y … Wang Y (International journal of clinical and experimental pathology 2015) 3 58
  3. miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma. (PMID: 26201446) Zhao L … Cao Y (Oncotarget 2015) 3 58
  4. Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders. (PMID: 26572867) Choi SY … Han K (Molecular brain 2015) 3 58
  5. microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma. (PMID: 24647829) Kikkawa N … Seki N (International journal of oncology 2014) 3 58

Products for MIR504 Gene

Sources for MIR504 Gene

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