microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR503 Gene

Subcategory (RNA class) for MIR503 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR503 Gene

  • MicroRNA 503 2 3 5
  • Hsa-MiR-503-5p 163 173
  • Hsa-Mir-503 2 3
  • MIR503 2 5
  • Hsa-MiR-503-3p 163
  • Hsa-Mir-15-P2d 178
  • MIMAT0022925 50
  • MIMAT0002874 50
  • MI0003188 50
  • MIRN503 3
  • Mir-503 3
  • RF00753 168

External Ids for MIR503 Gene

Previous HGNC Symbols for MIR503 Gene

  • MIRN503

Previous GeneCards Identifiers for MIR503 Gene

  • GC0XM133520
  • GC0XM133522
  • GC0XM133680
  • GC0XM134548
  • GC0XM134555
  • GC0XM134608
  • GC0XM134613
  • GC0XM134617
  • GC0XM134624
  • GC0XM134561
  • GC0XM134570
  • GC0XM134575
  • GC0XM134580
  • GC0XM134585
  • GC0XM134590
  • GC0XM134596
  • GC0XM134603

Summaries for MIR503 Gene

Entrez Gene Summary for MIR503 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR503 Gene

MIR503 (MicroRNA 503) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR503 include Retinoblastoma and Adrenocortical Carcinoma, Hereditary. Among its related pathways are Parkinsons Disease Pathway and miRNAs involved in DNA damage response.

Rfam classification for MIR503 Gene

Additional gene information for MIR503 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR503 Gene

Genomics for MIR503 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR503 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR503 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR503 Gene

Genomic Locations for MIR503 Gene
chrX:134,546,328-134,546,398
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand
chrX:133,680,358-133,680,428
(GRCh37/hg19)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR503 Gene

Genes around MIR503 on UCSC Golden Path with GeneCards custom track
MIR503 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR503 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR503 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR503 Gene

Proteins for MIR503 Gene

Post-translational modifications for MIR503 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR503 Gene

Domains & Families for MIR503 Gene

Gene Families for MIR503 Gene

genes like me logo Genes that share domains with MIR503: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR503 Gene

Function for MIR503 Gene

Phenotypes From GWAS Catalog for MIR503 Gene

Gene Ontology (GO) - Molecular Function for MIR503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21220732
genes like me logo Genes that share ontologies with MIR503: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR503 Gene

Localization for MIR503 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR503 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for MIR503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072563 endothelial microparticle IDA 26268439
genes like me logo Genes that share ontologies with MIR503: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR503 Gene

Pathways & Interactions for MIR503 Gene

genes like me logo Genes that share pathways with MIR503: view

Pathways by source for MIR503 Gene

Gene Ontology (GO) - Biological Process for MIR503 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 21220732
GO:0010596 negative regulation of endothelial cell migration IDA 21220732
GO:0010812 negative regulation of cell-substrate adhesion IDA 21220732
GO:0016525 negative regulation of angiogenesis IGI 28566713
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR503: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR503 Gene

Drugs & Compounds for MIR503 Gene

No Compound Related Data Available

Transcripts for MIR503 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR503 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006588D4_9606 precursor_RNA 71 6

HGNC: 32138,

RefSeq: NR_030228,

Ensembl: ENST00000385270 (view in UCSC) ,

miRBase: MI0003188,

Rfam: RF00753,

ENA: LM609502.1:1..71:precursor_RNA,

URS00000F6E49_9606 miRNA 23 6

RefSeq: NR_030228,

LncBase: hsa-miR-503-5p,

miRBase: MIMAT0002874,

MirGeneDB: Hsa-Mir-15-P2d_5p,

TarBase: hsa-miR-503-5p,

ENA: AY882283.1:1..23:ncRNA, LM379798.1:1..23:ncRNA, LM609502.1:6..28:ncRNA,

URS00003C11EC_9606 miRNA 23 5

RefSeq: NR_030228,

LncBase: hsa-miR-503-3p,

miRBase: MIMAT0022925,

MirGeneDB: Hsa-Mir-15-P2d_3p,

ENA: LM383085.1:1..23:ncRNA, LM609502.1:46..68:ncRNA,

URS0000EFEDF9_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-15-P2d,

MIR503 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR503 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR503 Gene

No ASD Table

Relevant External Links for MIR503 Gene

GeneLoc Exon Structure for
MIR503

Expression for MIR503 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR503

Evidence on tissue expression from TISSUES for MIR503 Gene

  • Blood(2)
  • Heart(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR503 Gene

Orthologs for MIR503 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR503 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Mir503 31
  • 89 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-503 31
  • 86 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-503 31
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-503 31
  • 53 (a)
OneToOne
Species where no ortholog for MIR503 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR503 Gene

ENSEMBL:
Gene Tree for MIR503 (if available)
TreeFam:
Gene Tree for MIR503 (if available)

Paralogs for MIR503 Gene

No data available for Paralogs for MIR503 Gene

Variants for MIR503 Gene

Additional dbSNP identifiers (rs#s) for MIR503 Gene

Additional Variant Information for MIR503 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR503

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR503 Gene

Disorders for MIR503 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MIR503 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
adrenocortical carcinoma, hereditary
  • adcc
prostate cancer
  • prostate cancer, somatic
limb ischemia
colon adenoma
  • adenomatous polyp of colon
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR503: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR503 Gene

Publications for MIR503 Gene

  1. miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies. (PMID: 22072795) Cui YH … Wang JY (Molecular biology of the cell 2012) 2 3
  2. [The Effect of miR-503-5p on the Proliferation, Invasion, Migration and Epithelial Interstitium of Cervical Cancer HeLa Cells via Targeting E2 F3]. (PMID: 32220185) Ran W … Liu XL (Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2020) 3
  3. IGF2-AS affects the prognosis and metastasis of gastric adenocarcinoma via acting as a ceRNA of miR-503 to regulate SHOX2. (PMID: 31183590) Huang J … Zhang B (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020) 3
  4. Can MiR-503 be used as a marker in diabetic patients with ischemic stroke? (PMID: 31035988) Sheikhbahaei S … Shaghayegh HJ (BMC endocrine disorders 2019) 3
  5. Effects of miR-503-5p on apoptosis of human pulmonary microvascular endothelial cells in simulated microgravity. (PMID: 30216505) Tang NP … Mei QB (Journal of cellular biochemistry 2019) 3

Products for MIR503 Gene

Sources for MIR503 Gene