microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5006 Gene

Subcategory (RNA class) for MIR5006 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR5006 Gene

  • MicroRNA 5006 2 3 5
  • Hsa-MiR-5006-3p 163 173
  • Hsa-Mir-5006 2 3
  • MIR5006 2 5
  • MIMAT0021034 50
  • MIMAT0021033 50
  • MI0017873 50

External Ids for MIR5006 Gene

Previous GeneCards Identifiers for MIR5006 Gene

  • GC13U900900
  • GC13M042145

Summaries for MIR5006 Gene

Entrez Gene Summary for MIR5006 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5006 Gene

MIR5006 (MicroRNA 5006) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5006 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5006 Gene

Genomics for MIR5006 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5006 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J041570 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 600.7 -0.6 -606 1.6 RFX1 PRDM1 BMI1 CTCF MIR5006 piR-58394 VWA8 piR-50308-144 ENSG00000288598 RGCC
GH13J041560 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +4.8 4756 5.5 PRDM10 SOX13 PRDM1 ZNF341 CEBPB ESR1 FOXA2 MAFF MAFK ATF2 RGCC VWA8 MIR5006 HSALNG0096632 ENSG00000288598 LOC105370174
GH13J041561 Enhancer 0.2 dbSUPER 0.4 +7.9 7945 0.1 HSALNG0096632 MIR5006 ENSG00000288598 LOC105370174 RGCC VWA8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5006 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5006 Gene

Genomic Locations for MIR5006 Gene
chr13:41,568,286-41,568,395
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr13:42,142,422-42,142,531
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR5006 Gene

Genes around MIR5006 on UCSC Golden Path with GeneCards custom track
MIR5006 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR5006 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5006 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5006 Gene

Proteins for MIR5006 Gene

Post-translational modifications for MIR5006 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5006 Gene

Domains & Families for MIR5006 Gene

Gene Families for MIR5006 Gene

HGNC:
genes like me logo Genes that share domains with MIR5006: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5006 Gene

Function for MIR5006 Gene

Phenotypes From GWAS Catalog for MIR5006 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5006 Gene

Localization for MIR5006 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5006 Gene

Pathways & Interactions for MIR5006 Gene

PathCards logo

SuperPathways for MIR5006 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5006 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5006 Gene

Drugs & Compounds for MIR5006 Gene

No Compound Related Data Available

Transcripts for MIR5006 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5006 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DA5C_9606 precursor_RNA 110 4

HGNC: 43495,

RefSeq: NR_049803,

Ensembl: ENST00000583027 (view in UCSC) ,

miRBase: MI0017873,

URS000055E32C_9606 miRNA 21 4

RefSeq: NR_049803,

LncBase: hsa-miR-5006-3p,

miRBase: MIMAT0021034,

TarBase: hsa-miR-5006-3p,

URS000075CF59_9606 miRNA 21 2

RefSeq: NR_049803,

miRBase: MIMAT0021033,

MIR5006 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5006 Gene

No ASD Table

Relevant External Links for MIR5006 Gene

GeneLoc Exon Structure for
MIR5006

No data available for mRNA/cDNA for MIR5006 Gene

Expression for MIR5006 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5006 Gene

genes like me logo Genes that share expression patterns with MIR5006: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5006 Gene

Orthologs for MIR5006 Gene

Evolution for MIR5006 Gene

ENSEMBL:
Gene Tree for MIR5006 (if available)
TreeFam:
Gene Tree for MIR5006 (if available)

No data available for Orthologs for MIR5006 Gene

Paralogs for MIR5006 Gene

No data available for Paralogs for MIR5006 Gene

Variants for MIR5006 Gene

Additional dbSNP identifiers (rs#s) for MIR5006 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR5006 Gene

Variant ID Type Subtype PubMed ID
dgv1634n100 CNV gain 25217958
nsv455865 CNV gain 19166990
nsv561539 CNV gain 21841781

Additional Variant Information for MIR5006 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5006

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR5006 Gene

Disorders for MIR5006 Gene

No disorders were found for MIR5006 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5006 Gene

Publications for MIR5006 Gene

  1. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen TB … Bramsen JB (RNA biology 2011) 3
  2. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5006 Gene

Sources for MIR5006 Gene