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MIR499A Gene(RNA Gene)

MicroRNA 499a

GCID:
GC20P034990
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR499A Gene

Subcategory (RNA class) for MIR499A Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR499A Gene

  • MicroRNA 499a 2 3 5
  • MicroRNA 499 2 3
  • Hsa-Mir-499a 3
  • Hsa-Mir-499 3
  • Mir-499a 3
  • MIRN499 3
  • MIR499 3

External Ids for MIR499A Gene

ORGUL Members for MIR499A Gene

Previous HGNC Symbols for MIR499A Gene

  • MIRN499
  • MIR499

Previous GeneCards Identifiers for MIR499A Gene

  • GC20U900690
  • GC20P033579

Summaries for MIR499A Gene

Entrez Gene Summary for MIR499A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR499A Gene

MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR499A include Acute Myocardial Infarction and Dilated Cardiomyopathy.

Additional gene information for MIR499A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR499A Gene

Genomics for MIR499A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR499A Gene

Promoters and enhancers for MIR499A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J035317 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.6 +329.4 329372 5.1 PKNOX1 FOXA2 ARNT FEZF1 ZNF48 GLIS2 ATF7 FOS SP3 YY2 UQCC1 EIF6 FAM83C MMP24 FAM83C-AS1 MMP24OS NCOA6 EDEM2 RBM12 MIR499A
GH20J034903 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11 -86.2 -86159 0.8 TEAD4 TAL1 BATF EED ATF7 ETV6 IKZF2 CREM SMARCE1 RXRA PIGU MIR499A EDEM2 MMP24OS ACSS2 TP53INP2 GC20P034899 MYH7B
GH20J034921 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -67.9 -67904 2.5 FOXA2 RAD21 RFX5 YY1 ZNF766 RCOR1 FOS DEK RXRA CEBPB PIGU GSS MIR499A EDEM2 MMP24OS NCOA6 GC20P034899 MYH7B ACSS2
GH20J035207 Enhancer 1.2 Ensembl ENCODE 10.1 +218.0 218024 1.4 FOXA2 ARNT ARID4B SIN3A ETS1 YY1 GTF3C2 TCF12 E2F8 ARID2 RBM12 TRPC4AP RBM39 NCOA6 ERGIC3 CPNE1 RPL36P4 EIF6 EDEM2 MMP24OS
GH20J034938 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.2 -51.4 -51357 2 ZFHX2 POLR2A HLF MAX MYC EGR2 PIGU MIR499A NCOA6 GSS MYH7B GC20P034899
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR499A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR499A Gene

Genomic Locations for MIR499A Gene
chr20:34,990,376-34,990,497
(GRCh38/hg38)
Size:
122 bases
Orientation:
Plus strand
chr20:33,578,179-33,578,300
(GRCh37/hg19)
Size:
122 bases
Orientation:
Plus strand

Genomic View for MIR499A Gene

Genes around MIR499A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR499A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR499A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR499A Gene

Proteins for MIR499A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR499A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR499A Gene

Domains & Families for MIR499A Gene

Gene Families for MIR499A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR499A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR499A Gene

Function for MIR499A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR499A Gene

Gene Ontology (GO) - Molecular Function for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20081117
genes like me logo Genes that share ontologies with MIR499A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR499A Gene

Localization for MIR499A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR499A Gene

Pathways & Interactions for MIR499A Gene

SuperPathways for MIR499A Gene

PathCards logo More details on SuperPathways for MIR499A
No Data Available

Interacting Proteins for MIR499A Gene

Gene Ontology (GO) - Biological Process for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014883 transition between fast and slow fiber ISS --
GO:0035195 gene silencing by miRNA IDA 20081117
GO:0035278 miRNA mediated inhibition of translation IDA 26184978
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26184978
GO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA 26184978
genes like me logo Genes that share ontologies with MIR499A: view

No data available for Pathways by source and SIGNOR curated interactions for MIR499A Gene

Drugs & Compounds for MIR499A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR499A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR499A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR499A Gene

No ASD Table

Relevant External Links for MIR499A Gene

GeneLoc Exon Structure for
MIR499A
ECgene alternative splicing isoforms for
MIR499A

Expression for MIR499A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR499A Gene

mRNA expression in normal human tissues for MIR499A Gene
mRNA expression by GTEx for MIR499A Gene

mRNA differential expression in normal tissues according to GTEx for MIR499A Gene

This gene is overexpressed in Pituitary (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR499A Gene:

MIR499A
genes like me logo Genes that share expression patterns with MIR499A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR499A Gene

Orthologs for MIR499A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR499A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-499 34
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-499 34
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-499 34
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir499 34
  • 91 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-499 34
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-499 34
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-499 34
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-499 34
  • 75 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii FP015790.1 34
  • 71 (a)
 OneToMany
CR847953.1 34
  • 71 (a)
 OneToMany
dre-mir-499 34
  • 70 (a)
 OneToMany
Species where no ortholog for MIR499A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR499A Gene

ENSEMBL:
Gene Tree for MIR499A (if available)
TreeFam:
Gene Tree for MIR499A (if available)

Paralogs for MIR499A Gene

No data available for Paralogs for MIR499A Gene

Variants for MIR499A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR499A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1001077088 -- 34,990,556(+) G/C downstream_transcript_variant
rs1002631481 -- 34,990,244(+) C/T upstream_transcript_variant
rs1003602086 -- 34,990,553(+) G/C downstream_transcript_variant
rs1003635255 -- 34,988,959(+) G/A upstream_transcript_variant
rs1003936365 -- 34,990,288(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR499A Gene

Variant ID Type Subtype PubMed ID
nsv833962 CNV loss 17160897
nsv3362 CNV insertion 18451855
nsv1063673 CNV loss 25217958
nsv1055447 CNV loss 25217958

Additional Variant Information for MIR499A Gene

Human Gene Mutation Database (HGMD)
MIR499A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR499A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR499A Gene

Disorders for MIR499A Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR499A Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
acute myocardial infarction
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
breast cancer
  • breast cancer, familial
lung cancer
  • lung cancer, susceptibility to
myocardial infarction
  • myocardial infarction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR499A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR499A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR499A Gene

Publications for MIR499A Gene

  1. Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs. (PMID: 28301487) Ranjha R … Paul J (PloS one 2017) 3 58
  2. Association between polymorphisms in pre-miRNA genes and risk of oral squamous cell cancer in a Chinese population. (PMID: 28609461) Zhang E … Lu L (PloS one 2017) 3 58
  3. Association of microRNA-125a and microRNA-499a polymorphisms in chronic periodontitis in a sample south Indian population: A hospital-based genetic association study. (PMID: 28732738) Venugopal P … Venkatesan V (Gene 2017) 3 58
  4. Effects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF-Κβ/TNF-α Signaling Pathway. (PMID: 29131009) Zhang YH … Shi G (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. MicroRNA 499 gene expression in patients on hemodialysis with cardiovascular complications. (PMID: 29064177) El Sharkawy M … Ezzat H (Hemodialysis international. International Symposium on Home Hemodialysis 2017) 3 58

Products for MIR499A Gene

Sources for MIR499A Gene

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