Aliases for MIR499A Gene
Subcategory (RNA class) for MIR499A Gene
miRNA
Quality Score for this RNA gene is
13
Aliases for MIR499A Gene
External Ids for MIR499A Gene
- HGNC: 32133
- Entrez Gene: 574501
- Ensembl: ENSG00000207635
- OMIM: 613614
- miRBase: hsa-mir-499a
- miRBase: hsa-mir-499b
Previous HGNC Symbols for MIR499A Gene
- MIRN499
- MIR499
Previous GeneCards Identifiers for MIR499A Gene
- GC20U900690
- GC20P033579
Summaries for MIR499A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR499A Gene
MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR499A include Acute Myocardial Infarction and Dilated Cardiomyopathy.
Additional gene information for MIR499A Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR499A Gene
Genomics for MIR499A Gene
GeneHancer (GH) Regulatory Elements for MIR499A Gene
Promoters and enhancers for MIR499A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR499A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR499A Gene
Genomic Locations for MIR499A Gene
- chr20:34,990,376-34,990,497
- (GRCh38/hg38)
- Size:
- 122 bases
- Orientation:
- Plus strand
- chr20:33,578,179-33,578,300
- (GRCh37/hg19)
- Size:
- 122 bases
- Orientation:
- Plus strand
Genomic View for MIR499A Gene
Genes around MIR499A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.22 by Entrez Gene
- 20q11.22 by HGNC
- 20q11.22 by Ensembl
MIR499A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR499A Gene
Proteins for MIR499A Gene
Post-translational modifications for MIR499A Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR499A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR499A
- Origene Custom Protein Services for MIR499A
- Search GeneTex for Proteins for MIR499A
No data available for DME Specific Peptides for MIR499A Gene
Domains & Families for MIR499A Gene
Gene Families for MIR499A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR499A Gene
Function for MIR499A Gene
Phenotypes From GWAS Catalog for MIR499A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20081117 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR499A
-
CRISPR Products
- Browse CRISPR knockouts for MIR499A
- Applied Biological Materials CRISPR for MIR499A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR499A
- VectorBuilder custom plasmid, inducible vectors for MIR499A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR499A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR499A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR499A Gene
Localization for MIR499A Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR499A Gene
Pathways & Interactions for MIR499A Gene
No Data Available
Interacting Proteins for MIR499A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0014883 | transition between fast and slow fiber | ISS | -- |
| GO:0035195 | gene silencing by miRNA | IDA | 20081117 |
| GO:0035278 | miRNA mediated inhibition of translation | IDA | 26184978 |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | IDA | 26184978 |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | IDA | 26184978 |
No data available for Pathways by source and SIGNOR curated interactions for MIR499A Gene
Transcripts for MIR499A Gene
mRNA/cDNA for MIR499A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000384903 122 bps (uc021wcg.1)
- (3) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIR499A
- Applied Biological Materials CRISPR for MIR499A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR499A
- VectorBuilder custom plasmid, inducible vectors for MIR499A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR499A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR499A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR499A Gene
mRNA differential expression in normal tissues according to GTEx for MIR499A Gene
This gene is overexpressed in Pituitary (x5.9).
NURSA nuclear receptor signaling pathways regulating expression of MIR499A Gene:
MIR499APrimer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR499A Gene
Orthologs for MIR499A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-499 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-mir-499 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | bta-mir-499 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir499 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-499 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-499 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-499 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | aca-mir-499 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | FP015790.1 34 |
|
OneToMany | |
| CR847953.1 34 |
|
OneToMany | |||
| dre-mir-499 34 |
|
OneToMany |
- Species where no ortholog for MIR499A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR499A Gene
No data available for Paralogs for MIR499A Gene
Variants for MIR499A Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001077088 | -- | 34,990,556(+) | G/C | downstream_transcript_variant | |
| rs1002631481 | -- | 34,990,244(+) | C/T | upstream_transcript_variant | |
| rs1003602086 | -- | 34,990,553(+) | G/C | downstream_transcript_variant | |
| rs1003635255 | -- | 34,988,959(+) | G/A | upstream_transcript_variant | |
| rs1003936365 | -- | 34,990,288(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1055447 | CNV | loss | 25217958 |
| nsv1063673 | CNV | loss | 25217958 |
| nsv3362 | CNV | insertion | 18451855 |
| nsv833962 | CNV | loss | 17160897 |
Additional Variant Information for MIR499A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR499A Gene
Disorders for MIR499A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute myocardial infarction |
|
|
| dilated cardiomyopathy |
|
|
| breast cancer |
|
|
| lung cancer |
|
|
| myocardial infarction |
|
Search MIR499A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR499A
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR499A Gene
Publications for MIR499A Gene
- Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs. (PMID: 28301487) Ranjha R … Paul J (PloS one 2017) 3 58
- Association between polymorphisms in pre-miRNA genes and risk of oral squamous cell cancer in a Chinese population. (PMID: 28609461) Zhang E … Lu L (PloS one 2017) 3 58
- Association of microRNA-125a and microRNA-499a polymorphisms in chronic periodontitis in a sample south Indian population: A hospital-based genetic association study. (PMID: 28732738) Venugopal P … Venkatesan V (Gene 2017) 3 58
- Effects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF-Κβ/TNF-α Signaling Pathway. (PMID: 29131009) Zhang YH … Shi G (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
- MicroRNA 499 gene expression in patients on hemodialysis with cardiovascular complications. (PMID: 29064177) El Sharkawy M … Ezzat H (Hemodialysis international. International Symposium on Home Hemodialysis 2017) 3 58
Products for MIR499A Gene
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- Lentiviral ORF Clones
- VectorBuilder custom plasmid, inducible vectors for MIR499A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR499A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR499A
- Search GeneTex for Proteins for MIR499A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR499A
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Sources for MIR499A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt