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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR499A include Acute Myocardial Infarction and Dilated Cardiomyopathy.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20081117 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016442 | RISC complex | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0014883 | transition between fast and slow fiber | ISS | -- |
GO:0035195 | gene silencing by miRNA | IEA,IDA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 26184978 |
GO:0043536 | positive regulation of blood vessel endothelial cell migration | IDA | 26184978 |
GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | IDA | 26184978 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
dog (Canis familiaris) |
Mammalia | cfa-mir-499 33 |
|
OneToOne | |
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-499 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | bta-mir-499 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mir499 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-499 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-499 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | gga-mir-499 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | aca-mir-499 33 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | FP015790.1 33 |
|
OneToMany | |
CR847953.1 33 |
|
OneToMany | |||
dre-mir-499 33 |
|
OneToMany |
SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1555894731 | uncertain-significance, not provided | 34,989,783(+) | C/T | upstream_transcript_variant | |
rs1001077088 | -- | 34,990,556(+) | G/C | downstream_transcript_variant | |
rs1002631481 | -- | 34,990,244(+) | C/T | upstream_transcript_variant | |
rs1003602086 | -- | 34,990,553(+) | G/C | downstream_transcript_variant | |
rs1003635255 | -- | 34,988,959(+) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1055447 | CNV | loss | 25217958 |
nsv1063673 | CNV | loss | 25217958 |
nsv3362 | CNV | insertion | 18451855 |
nsv833962 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute myocardial infarction |
|
|
dilated cardiomyopathy |
|
|
lung cancer |
|
|
breast cancer |
|
|
myocardial infarction |
|