microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR499A Gene

Subcategory (RNA class) for MIR499A Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR499A Gene

  • MicroRNA 499a 2 3 5
  • Hsa-MiR-499a-3p 168 179
  • Hsa-MiR-499a-5p 168 179
  • MicroRNA 499 2 3
  • Hsa-Mir-499a 3
  • MIMAT0002870 53
  • MIMAT0004772 53
  • Hsa-Mir-499 3
  • MI0003183 53
  • Mir-499a 3
  • MIRN499 3
  • RF00745 174
  • MIR499A 2
  • MIR499 3

External Ids for MIR499A Gene

Previous HGNC Symbols for MIR499A Gene

  • MIRN499
  • MIR499

Previous GeneCards Identifiers for MIR499A Gene

  • GC20U900690
  • GC20P033579

Summaries for MIR499A Gene

Entrez Gene Summary for MIR499A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR499A Gene

MIR499A (MicroRNA 499a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR499A include Acute Myocardial Infarction and Dilated Cardiomyopathy.

Rfam classification for MIR499A Gene

Additional gene information for MIR499A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR499A Gene

Genomics for MIR499A Gene

GeneHancer (GH) Regulatory Elements for MIR499A Gene

Promoters and enhancers for MIR499A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J035301 Promoter/Enhancer 2.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +321.5 321479 20.9 SIN3A CTCF ZBTB6 FOXA1 MLX RBPJ SMARCE1 POLR2A USF2 CTBP1 UQCC1 EIF6 GDF5 MMP24 FAM83C-AS1 MMP24OS EDEM2 CEP250 MIR1289-1 MIR499A
GH20J034903 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -84.0 -83976 5.6 SMARCE1 ETV6 TEAD4 NFIB SP7 CREM IKZF1 ZNF24 POLR2A RXRA NCOA6 PIGU MIR499A EDEM2 MMP24 MMP24OS TRPC4AP ACSS2 TP53INP2 piR-59804-013
GH20J035343 Enhancer 1.2 Ensembl ENCODE dbSUPER 10 +354.2 354225 2 HLF RAD21 DACH1 TEAD4 NFIB ELF3 SP1 CBFA2T2 CEBPG SMARCA4 MIR1289-1 GDF5 CEP250 MIR499A lnc-FAM83C-2 lnc-FAM83C-3 UQCC1
GH20J034921 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.5 -67.9 -67904 2.5 RAD21 MNT SP1 CEBPG CEBPA RXRA GATAD2A FOXA2 CEBPB CHD2 PIGU GSS MIR499A EDEM2 MMP24OS NCOA6 piR-59804-013 MYH7B ACSS2
GH20J034943 Enhancer 1 Ensembl ENCODE dbSUPER 11.7 -45.4 -45434 2.8 PRDM10 CEBPB ZNF692 JUN JUND MAX SCRT2 ZBTB48 EP300 STAT3 NCOA6 PIGU MIR499A GSS MYH7B piR-59804-013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR499A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR499A Gene

Genomic Locations for MIR499A Gene
chr20:34,990,376-34,990,497
(GRCh38/hg38)
Size:
122 bases
Orientation:
Plus strand
chr20:33,578,179-33,578,300
(GRCh37/hg19)
Size:
122 bases
Orientation:
Plus strand

Genomic View for MIR499A Gene

Genes around MIR499A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR499A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR499A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR499A Gene

Proteins for MIR499A Gene

Post-translational modifications for MIR499A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR499A Gene

Domains & Families for MIR499A Gene

Gene Families for MIR499A Gene

HGNC:
genes like me logo Genes that share domains with MIR499A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR499A Gene

Function for MIR499A Gene

Phenotypes From GWAS Catalog for MIR499A Gene

Gene Ontology (GO) - Molecular Function for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20081117
genes like me logo Genes that share ontologies with MIR499A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR499A Gene

Localization for MIR499A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR499A gene
Compartment Confidence
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR499A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR499A Gene

Pathways & Interactions for MIR499A Gene

PathCards logo

SuperPathways for MIR499A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR499A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014883 transition between fast and slow fiber ISS --
GO:0035195 gene silencing by miRNA IEA,IDA --
GO:0035278 miRNA mediated inhibition of translation IDA 26184978
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26184978
GO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA 26184978
genes like me logo Genes that share ontologies with MIR499A: view

No data available for Pathways by source and SIGNOR curated interactions for MIR499A Gene

Drugs & Compounds for MIR499A Gene

No Compound Related Data Available

Transcripts for MIR499A Gene

mRNA/cDNA for MIR499A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(2) TarBase transcripts :
(5) ENA transcripts :
(2) LncBase transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR499A Gene

No ASD Table

Relevant External Links for MIR499A Gene

GeneLoc Exon Structure for
MIR499A
ECgene alternative splicing isoforms for
MIR499A

Expression for MIR499A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR499A Gene

mRNA differential expression in normal tissues according to GTEx for MIR499A Gene

This gene is overexpressed in Pituitary (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR499A Gene:

MIR499A

Evidence on tissue expression from TISSUES for MIR499A Gene

  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR499A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR499A Gene

Orthologs for MIR499A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR499A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-499 33
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-499 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-499 33
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir499 33
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-499 33
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-499 33
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-499 33
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-499 33
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FP015790.1 33
  • 71 (a)
OneToMany
CR847953.1 33
  • 71 (a)
OneToMany
dre-mir-499 33
  • 70 (a)
OneToMany
Species where no ortholog for MIR499A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR499A Gene

ENSEMBL:
Gene Tree for MIR499A (if available)
TreeFam:
Gene Tree for MIR499A (if available)

Paralogs for MIR499A Gene

No data available for Paralogs for MIR499A Gene

Variants for MIR499A Gene

Sequence variations from dbSNP and Humsavar for MIR499A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1555894731 uncertain-significance, not provided 34,989,783(+) C/T upstream_transcript_variant
rs1001077088 -- 34,990,556(+) G/C downstream_transcript_variant
rs1002631481 -- 34,990,244(+) C/T upstream_transcript_variant
rs1003602086 -- 34,990,553(+) G/C downstream_transcript_variant
rs1003635255 -- 34,988,959(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR499A Gene

Variant ID Type Subtype PubMed ID
nsv1055447 CNV loss 25217958
nsv1063673 CNV loss 25217958
nsv3362 CNV insertion 18451855
nsv833962 CNV loss 17160897

Additional Variant Information for MIR499A Gene

Human Gene Mutation Database (HGMD)
MIR499A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR499A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR499A Gene

Disorders for MIR499A Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR499A Gene - From: miR2Disease, HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acute myocardial infarction
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
lung cancer
  • adenocarcinoma of lung
breast cancer
  • breast cancer, familial
myocardial infarction
  • myocardial infarction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR499A

genes like me logo Genes that share disorders with MIR499A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR499A Gene

Publications for MIR499A Gene

  1. Single nucleotide polymorphism rs3746444 in miR‑499a affects susceptibility to non‑small cell lung carcinoma by regulating the expression of CD200. (PMID: 30864695) Ge N … Li C (International journal of molecular medicine 2019) 3 56
  2. Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population. (PMID: 30637557) Kim JO … Kim NK (Journal of thrombosis and thrombolysis 2019) 3 56
  3. miRNA Polymorphisms and Risk of Cardio-Cerebrovascular Diseases: A Systematic Review and Meta-Analysis. (PMID: 30642078) Bastami M … Nariman-Saleh-Fam Z (International journal of molecular sciences 2019) 3 56
  4. MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4. (PMID: 30856535) Sun JC … Guo YF (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 56
  5. Association between miR-499 rs3746444 polymorphism and coronary heart disease susceptibility: An evidence-based meta-analysis of 5063 cases and 4603 controls. (PMID: 30802538) Lu JY … Liao PH (Gene 2019) 3 56

Products for MIR499A Gene

Sources for MIR499A Gene