microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4999 Gene

Subcategory (RNA class) for MIR4999 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR4999 Gene

  • MicroRNA 4999 2 3 5
  • Hsa-MiR-4999-5p 163 173
  • Hsa-Mir-4999 2 3
  • MIR4999 2 5
  • MIMAT0021017 50
  • MIMAT0021018 50
  • MI0017865 50
  • Mir-4999 3

External Ids for MIR4999 Gene

Previous GeneCards Identifiers for MIR4999 Gene

  • GC19U901577
  • GC19M008456

Summaries for MIR4999 Gene

Entrez Gene Summary for MIR4999 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4999 Gene

MIR4999 (MicroRNA 4999) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4999 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4999 Gene

Genomics for MIR4999 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4999 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008387 Enhancer 1 Ensembl ENCODE dbSUPER 600.7 +2.0 1992 0.5 ZNF740 MEF2D ZNF592 GTF2A2 RELA POLR2A TFDP1 HDAC8 SMAD5 ADNP MIR4999 ZNF558 ZNF699 HNRNPM ELAVL1 ZNF559 ZNF317 XAB2 ENSG00000269300 ANGPTL4
GH19J008388 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -3.5 -3464 10.3 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 RAB11B-AS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 ZNF317 XAB2 ENSG00000270614 ENSG00000269300
GH19J008385 Enhancer 1 Ensembl ENCODE dbSUPER 0.7 +4.1 4145 3.3 ZNF512 PKNOX1 ZNF740 SP2 ZNF316 MAFG POLR2A CEBPG TFDP1 SMAD5 piR-31846-007 piR-49156-013 ANGPTL4 MARCHF2 RPS28 RAB11B MIR4999 RAB11B-AS1 lnc-KANK3-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4999 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4999 Gene

Genomic Locations for MIR4999 Gene
chr19:8,389,290-8,389,380
(GRCh38/hg38)
Size:
91 bases
Orientation:
Minus strand
chr19:8,454,174-8,454,264
(GRCh37/hg19)
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR4999 Gene

Genes around MIR4999 on UCSC Golden Path with GeneCards custom track
MIR4999 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4999 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4999 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4999 Gene

Proteins for MIR4999 Gene

Post-translational modifications for MIR4999 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4999 Gene

Domains & Families for MIR4999 Gene

Gene Families for MIR4999 Gene

HGNC:
genes like me logo Genes that share domains with MIR4999: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4999 Gene

Function for MIR4999 Gene

Phenotypes From GWAS Catalog for MIR4999 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4999 Gene

Localization for MIR4999 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4999 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4999 Gene

Pathways & Interactions for MIR4999 Gene

PathCards logo

SuperPathways for MIR4999 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4999 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4999 Gene

Drugs & Compounds for MIR4999 Gene

No Compound Related Data Available

Transcripts for MIR4999 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4999 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A513_9606 precursor_RNA 91 5

HGNC: 43494,

RefSeq: NR_049795,

Ensembl: ENST00000585029 (view in UCSC) ,

miRBase: MI0017865,

ENA: LM611498.1:1..91:precursor_RNA,

URS000075CA38_9606 miRNA 21 5

RefSeq: NR_049795,

LncBase: hsa-miR-4999-5p,

miRBase: MIMAT0021017,

TarBase: hsa-miR-4999-5p,

ENA: LM382878.1:1..21:ncRNA, LM611498.1:21..41:ncRNA,

URS000075BC86_9606 miRNA 20 3

RefSeq: NR_049795,

miRBase: MIMAT0021018,

ENA: LM611498.1:51..70:ncRNA,

MIR4999 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4999 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4999 Gene

No ASD Table

Relevant External Links for MIR4999 Gene

GeneLoc Exon Structure for
MIR4999

Expression for MIR4999 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4999 Gene

genes like me logo Genes that share expression patterns with MIR4999: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4999 Gene

Orthologs for MIR4999 Gene

Evolution for MIR4999 Gene

ENSEMBL:
Gene Tree for MIR4999 (if available)
TreeFam:
Gene Tree for MIR4999 (if available)

No data available for Orthologs for MIR4999 Gene

Paralogs for MIR4999 Gene

No data available for Paralogs for MIR4999 Gene

Variants for MIR4999 Gene

Additional dbSNP identifiers (rs#s) for MIR4999 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4999 Gene

Variant ID Type Subtype PubMed ID
esv3643614 CNV gain 21293372

Additional Variant Information for MIR4999 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4999

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4999 Gene

Disorders for MIR4999 Gene

Additional Disease Information for MIR4999

No disorders were found for MIR4999 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4999 Gene

Publications for MIR4999 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen TB … Bramsen JB (RNA biology 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4999 Gene

Sources for MIR4999 Gene