microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR498 Gene

RNA type for MIR498 Gene

miRNA

Aliases for MIR498 Gene

External Ids for MIR498 Gene

Previous HGNC Symbols for MIR498 Gene

  • MIRN498

Previous GeneCards Identifiers for MIR498 Gene

  • GC19P058871
  • GC19P054177
  • GC19P053675
  • GC19P053681
  • GC19P053971
  • GC19P054004
  • GC19P054030
  • GC19P054090
  • GC19P053691
  • GC19P053719
  • GC19P053759
  • GC19P053792
  • GC19P053799
  • GC19P053861
  • GC19P053912
  • GC19P053946
  • GC19P054606
  • GC19P055556

Summaries for MIR498 Gene

Entrez Gene Summary for MIR498 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR498 Gene

MIR498 (MicroRNA 498) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR498 include Retinoblastoma and Leiomyoma, Uterine.

Rfam classification for MIR498 Gene

Additional gene information for MIR498 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR498 Gene

Genomics for MIR498 Gene

Genomic Locations for MIR498 Gene

Latest Assembly
chr19:53,674,197-53,674,320
(GRCh38/hg38)
Size:
124 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,177,451-54,177,574
(GRCh37/hg19 by Entrez Gene)
Size:
124 bases
Orientation:
Plus strand

chr19:54,177,451-54,177,574
(GRCh37/hg19 by Ensembl)
Size:
124 bases
Orientation:
Plus strand

Genomic View for MIR498 Gene

Genes around MIR498 on UCSC Golden Path with GeneCards custom track
MIR498 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR498 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR498 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR498 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR498 Gene

Proteins for MIR498 Gene

Post-translational modifications for MIR498 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR498 Gene

Domains & Families for MIR498 Gene

Gene Families for MIR498 Gene

HGNC:
genes like me logo Genes that share domains with MIR498: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR498 Gene

Function for MIR498 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR498 Gene

Localization for MIR498 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR498 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR498 Gene

Pathways & Interactions for MIR498 Gene

PathCards logo

SuperPathways for MIR498 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR498 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR498: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR498 Gene

Drugs & Compounds for MIR498 Gene

No Compound Related Data Available

Transcripts for MIR498 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR498 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004CCA62_9606 miRNA 23 6

RefSeq: NR_030182,

LncBase: hsa-miR-498,

miRBase: MIMAT0002824,

MirGeneDB: Hsa-Mir-498_5p,

TarBase: hsa-miR-498,

ENA: AY882319.1:1..23:ncRNA, LM379780.1:1..23:ncRNA, LM609472.1:34..56:ncRNA,

URS00006C7250_9606 pre_miRNA 124 5

RefSeq: NR_030182,

Ensembl: ENST00000385134 (view in UCSC) ,

miRBase: MI0003142,

Rfam: RF00958,

ENA: LM609472.1:1..124:precursor_RNA,

URS0000D5237C_9606 miRNA 23 2

RefSeq: NR_030182,

miRBase: MIMAT0037323,

URS0001BC2E22_9606 pre_miRNA 124 1

Rfam: RF00958,

URS0000EFE289_9606 pre_miRNA 61 1

MirGeneDB: Hsa-Mir-498,

MIR498 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR498 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR498 Gene

No ASD Table

Relevant External Links for MIR498 Gene

GeneLoc Exon Structure for
MIR498

Expression for MIR498 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR498 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR498

genes like me logo Genes that share expression patterns with MIR498: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR498 Gene

Orthologs for MIR498 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR498 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-498 30
  • 97 (a)
OneToOne
Species where no ortholog for MIR498 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR498 Gene

ENSEMBL:
Gene Tree for MIR498 (if available)
TreeFam:
Gene Tree for MIR498 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR498

Paralogs for MIR498 Gene

No data available for Paralogs for MIR498 Gene

Variants for MIR498 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR498 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR498 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv1055718 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781

Additional Variant Information for MIR498 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR498
Leiden Open Variation Database (LOVD)
MIR498

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR498 Gene

Disorders for MIR498 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR498 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
leiomyoma, uterine
  • ul
squamous cell carcinoma, head and neck
  • hnscc
ovarian cancer
  • ovarian cancer, somatic
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR498

genes like me logo Genes that share disorders with MIR498: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR498 Gene

Publications for MIR498 Gene

  1. Long Non-Coding RNA Taurine Upregulated Gene 1 (TUG1) Downregulation Constrains Cell Proliferation and Invasion through Regulating Cell Division Cycle 42 (CDC42) Expression Via MiR-498 in Esophageal Squamous Cell Carcinoma Cells. (PMID: 32139664) Wang Z … Tang J (Medical science monitor : international medical journal of experimental and clinical research 2020) 3
  2. Down-regulation of long non-coding RNA DUXAP8 suppresses proliferation, metastasis and EMT by modulating miR-498 through TRIM44-mediated AKT/mTOR pathway in non-small-cell lung cancer. (PMID: 32271433) Ji X … Ling W (European review for medical and pharmacological sciences 2020) 3
  3. Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis. (PMID: 32541093) Liu G … Ji Z (Aging 2020) 3
  4. MicroRNA-498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl-2. (PMID: 31769193) Wang T … Gao H (FEBS open bio 2020) 3
  5. Upregulating microRNA-498 inhibits gastric cancer proliferation invasion and chemoresistance through inverse interaction of Bmi1. (PMID: 30518783) Zhao T … Zhang T (Cancer gene therapy 2019) 3

Products for MIR498 Gene

Sources for MIR498 Gene