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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR496 (MicroRNA 496) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14J101058 | Enhancer | 0.3 | Ensembl | 750.6 | -1.8 | -1772 | 1.6 | JUN FOS | MIR154 MIR496 RF00641-005 MIR323B | |
GH14J101232 | Enhancer | 0.9 | Ensembl CraniofacialAtlas | 9.6 | +173.5 | 173527 | 3.4 | CTCF RBPJ RAD21 ELF3 KAT8 ZIC2 REST GATAD2A RXRB ZSCAN4 | MIR370 MIR655 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR1185-1 MIR300 | |
GH14J101096 | Enhancer | 0.8 | FANTOM5 Ensembl ENCODE | 11 | +37.7 | 37694 | 3.3 | MAFK JUN POLR2A | RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154 | |
GH14J101004 | Enhancer | 0.6 | ENCODE CraniofacialAtlas | 11 | -55.5 | -55488 | 1.9 | TCF7L2 MYC MNT | MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2 | |
GH14J101176 | Enhancer | 0.5 | Ensembl ENCODE | 10.7 | +116.8 | 116793 | 2 | ZNF680 RCOR1 | MEG8 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A ENSG00000258399 SNORD113-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016442 | RISC complex | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-496 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | cfa-mir-496 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mir496 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | bta-mir-496 33 |
|
OneToOne |
SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001204786 | -- | 101,059,431(+) | T/C | upstream_transcript_variant | |
rs1001278131 | -- | 101,059,011(+) | G/A | upstream_transcript_variant | |
rs1001675581 | -- | 101,059,634(+) | T/C | upstream_transcript_variant | |
rs1003403054 | -- | 101,060,227(+) | T/C | upstream_transcript_variant | |
rs1004576493 | -- | 101,060,396(+) | C/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3635521 | CNV | gain | 21293372 |
nsv1040993 | CNV | gain | 25217958 |
nsv509551 | CNV | insertion | 20534489 |
nsv565859 | CNV | gain | 21841781 |
nsv565860 | CNV | gain | 21841781 |
No disorders were found for MIR496 Gene.