microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR496 Gene

Subcategory (RNA class) for MIR496 Gene

miRNA

Quality Score for this RNA gene is

15

Aliases for MIR496 Gene

  • MicroRNA 496 2 3 5
  • MIMAT0002818 53
  • Hsa-Mir-496 3
  • MI0003136 53
  • Mir-496 3
  • MIRN496 3
  • RF00641 174
  • MIR496 2

External Ids for MIR496 Gene

Previous HGNC Symbols for MIR496 Gene

  • MIRN496

Previous GeneCards Identifiers for MIR496 Gene

  • GC14P100837
  • GC14P100927
  • GC14P101528
  • GC14P101557
  • GC14P101591
  • GC14P101630
  • GC14P101658
  • GC14P101692
  • GC14P101730
  • GC14P101770
  • GC14P101828
  • GC14P101968
  • GC14P102165
  • GC14P101270
  • GC14P101886
  • GC14P103637
  • GC14P103855
  • GC14P102202
  • GC14P102370
  • GC14P102541
  • GC14P102719
  • GC14P102892
  • GC14P103068
  • GC14P103264
  • GC14P103454

Summaries for MIR496 Gene

Entrez Gene Summary for MIR496 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR496 Gene

MIR496 (MicroRNA 496) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR496 Gene

Additional gene information for MIR496 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR496 Gene

Genomics for MIR496 Gene

GeneHancer (GH) Regulatory Elements for MIR496 Gene

Promoters and enhancers for MIR496 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101058 Enhancer 0.3 Ensembl 750.6 -1.8 -1772 1.6 JUN FOS MIR154 MIR496 RF00641-005 MIR323B
GH14J101232 Enhancer 0.9 Ensembl CraniofacialAtlas 9.6 +173.5 173527 3.4 CTCF RBPJ RAD21 ELF3 KAT8 ZIC2 REST GATAD2A RXRB ZSCAN4 MIR370 MIR655 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR1185-1 MIR300
GH14J101096 Enhancer 0.8 FANTOM5 Ensembl ENCODE 11 +37.7 37694 3.3 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101004 Enhancer 0.6 ENCODE CraniofacialAtlas 11 -55.5 -55488 1.9 TCF7L2 MYC MNT MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14J101176 Enhancer 0.5 Ensembl ENCODE 10.7 +116.8 116793 2 ZNF680 RCOR1 MEG8 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A ENSG00000258399 SNORD113-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR496 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR496 Gene

Genomic Locations for MIR496 Gene
chr14:101,060,573-101,060,674
(GRCh38/hg38)
Size:
102 bases
Orientation:
Plus strand
chr14:101,526,910-101,527,011
(GRCh37/hg19)
Size:
102 bases
Orientation:
Plus strand

Genomic View for MIR496 Gene

Genes around MIR496 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR496 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR496 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR496 Gene

Proteins for MIR496 Gene

Post-translational modifications for MIR496 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR496 Gene

Domains & Families for MIR496 Gene

Gene Families for MIR496 Gene

genes like me logo Genes that share domains with MIR496: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR496 Gene

Function for MIR496 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR496 Gene

Localization for MIR496 Gene

Gene Ontology (GO) - Cellular Components for MIR496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR496: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR496 Gene

Pathways & Interactions for MIR496 Gene

PathCards logo

SuperPathways for MIR496 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR496 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR496: view

No data available for Pathways by source and SIGNOR curated interactions for MIR496 Gene

Drugs & Compounds for MIR496 Gene

No Compound Related Data Available

Transcripts for MIR496 Gene

mRNA/cDNA for MIR496 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(5) ENA transcripts :
(2) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR496 Gene

No ASD Table

Relevant External Links for MIR496 Gene

GeneLoc Exon Structure for
MIR496
ECgene alternative splicing isoforms for
MIR496

Expression for MIR496 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR496 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR496 Gene:

MIR496
genes like me logo Genes that share expression patterns with MIR496: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR496 Gene

Orthologs for MIR496 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR496 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-496 33
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-496 33
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir496 33
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-496 33
  • 79 (a)
OneToOne
Species where no ortholog for MIR496 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR496 Gene

ENSEMBL:
Gene Tree for MIR496 (if available)
TreeFam:
Gene Tree for MIR496 (if available)

Paralogs for MIR496 Gene

No data available for Paralogs for MIR496 Gene

Variants for MIR496 Gene

Sequence variations from dbSNP and Humsavar for MIR496 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001204786 -- 101,059,431(+) T/C upstream_transcript_variant
rs1001278131 -- 101,059,011(+) G/A upstream_transcript_variant
rs1001675581 -- 101,059,634(+) T/C upstream_transcript_variant
rs1003403054 -- 101,060,227(+) T/C upstream_transcript_variant
rs1004576493 -- 101,060,396(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR496 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR496 Gene

Human Gene Mutation Database (HGMD)
MIR496
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR496

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR496 Gene

Disorders for MIR496 Gene

Additional Disease Information for MIR496

No disorders were found for MIR496 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR496 Gene

Publications for MIR496 Gene

  1. Human papillomavirus 16 E6 modulates the expression of miR-496 in oropharyngeal cancer. (PMID: 29935424) Mason D … Tran N (Virology 2018) 3 56
  2. microRNA-496 - A new, potentially aging-relevant regulator of mTOR. (PMID: 27097372) Rubie C … Glanemann M (Cell cycle (Georgetown, Tex.) 2016) 3 56
  3. Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line. (PMID: 24204564) Alvarado S … Szyf M (PloS one 2013) 3 56
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 56
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 56

Products for MIR496 Gene

Sources for MIR496 Gene