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Aliases for MIR495 Gene

Subcategory (RNA class) for MIR495 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR495 Gene

  • MicroRNA 495 2 3 5
  • Hsa-Mir-495 3
  • Mir-495 3
  • MIRN495 3

External Ids for MIR495 Gene

ORGUL Members for MIR495 Gene

Previous HGNC Symbols for MIR495 Gene

  • MIRN495

Previous GeneCards Identifiers for MIR495 Gene

  • GC14P100821
  • GC14P100912
  • GC14P101504
  • GC14P101505
  • GC14P101569
  • GC14P101611
  • GC14P101636
  • GC14P101670
  • GC14P101711
  • GC14P101752
  • GC14P101810
  • GC14P101950
  • GC14P102141
  • GC14P101247
  • GC14P101852
  • GC14P102105
  • GC14P102339
  • GC14P102512
  • GC14P102691
  • GC14P102859
  • GC14P103035

Summaries for MIR495 Gene

Entrez Gene Summary for MIR495 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR495 Gene

MIR495 (MicroRNA 495) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR495 include Ovarian Epithelial Cancer and Muscular Dystrophy, Limb-Girdle, Type 2A. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR495 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR495 Gene

Genomics for MIR495 Gene

GeneHancer (GH) Regulatory Elements for MIR495 Gene

Promoters and enhancers for MIR495 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101215 Enhancer 0.8 ENCODE 9.9 +183.0 182969 2.8 FOXA2 ARID4B RAD21 ZNF48 ZSCAN9 RARA CREM RXRA CEBPB NR2F2 LOC100128373 SNORD113-3 SNORD113-8 SNORD113-9 SNORD113-4 SNORD113-6 SNORD113-7 MIR543 ENSG00000222185 ENSG00000222095
GH14J101096 Enhancer 0.7 FANTOM5 ENCODE 10.1 +64.6 64593 3.2 ATF4 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101176 Enhancer 0.5 ENCODE 10.1 +143.6 143611 2 ZNF680 ZFP3 RCOR1 CHD2 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR495 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR495 Gene

Genomic Locations for MIR495 Gene
chr14:101,033,755-101,033,836
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr14:101,500,092-101,500,173
(GRCh37/hg19)
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR495 Gene

Genes around MIR495 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR495 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR495 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR495 Gene

Proteins for MIR495 Gene

Post-translational modifications for MIR495 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR495 Gene

Domains & Families for MIR495 Gene

Gene Families for MIR495 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR495: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR495 Gene

Function for MIR495 Gene

Gene Ontology (GO) - Molecular Function for MIR495 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25466836
genes like me logo Genes that share ontologies with MIR495: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR495 Gene

Localization for MIR495 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR495 Gene

Pathways & Interactions for MIR495 Gene

genes like me logo Genes that share pathways with MIR495: view

Pathways by source for MIR495 Gene

1 BioSystems pathway for MIR495 Gene

Interacting Proteins for MIR495 Gene

Gene Ontology (GO) - Biological Process for MIR495 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 25466836
GO:0045602 negative regulation of endothelial cell differentiation IMP 27538588
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP 27538588
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IDA 25466836
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP 27538588
genes like me logo Genes that share ontologies with MIR495: view

No data available for SIGNOR curated interactions for MIR495 Gene

Drugs & Compounds for MIR495 Gene

No Compound Related Data Available

Transcripts for MIR495 Gene

mRNA/cDNA for MIR495 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR495 Gene

No ASD Table

Relevant External Links for MIR495 Gene

GeneLoc Exon Structure for
MIR495
ECgene alternative splicing isoforms for
MIR495

Expression for MIR495 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR495 Gene:

MIR495
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR495 Gene

Orthologs for MIR495 Gene

Evolution for MIR495 Gene

ENSEMBL:
Gene Tree for MIR495 (if available)
TreeFam:
Gene Tree for MIR495 (if available)

No data available for Orthologs for MIR495 Gene

Paralogs for MIR495 Gene

No data available for Paralogs for MIR495 Gene

Variants for MIR495 Gene

Sequence variations from dbSNP and Humsavar for MIR495 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000647555 -- 101,032,212(+) T/C upstream_transcript_variant
rs1000703711 -- 101,032,505(+) C/T upstream_transcript_variant
rs1000939457 -- 101,034,013(+) G/A downstream_transcript_variant
rs1001927063 -- 101,033,390(+) C/T upstream_transcript_variant
rs1004701762 -- 101,034,254(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR495 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR495 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR495

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR495 Gene

Disorders for MIR495 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR495 Gene - From: miR2Disease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR495

genes like me logo Genes that share disorders with MIR495: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR495 Gene

Publications for MIR495 Gene

  1. MicroRNA-495-3p functions as a tumor suppressor by regulating multiple epigenetic modifiers in gastric carcinogenesis. (PMID: 28991363) Eun JW … Nam SW (The Journal of pathology 2018) 3 58
  2. MiR-495 Promotes Senescence of Mesenchymal Stem Cells by Targeting Bmi-1. (PMID: 28628915) Li X … Zhao G (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  3. The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells. (PMID: 29224019) Bai Z … Zhang Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  4. Demethylation of miR-495 inhibits cell proliferation, migration and promotes apoptosis by targeting STAT-3 in breast cancer. (PMID: 28498478) Chen Y … Zhang X (Oncology reports 2017) 3 58
  5. LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21 expression and negatively regulating miR-495. (PMID: 28466784) Lu Y … Shi XH (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR495 Gene

Sources for MIR495 Gene

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