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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR494 (MicroRNA 494) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR494 include Lymphoplasmacytic Lymphoma and Heart Disease. Among its related pathways are MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 25085941 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903561 | extracellular vesicle | HDA | 28798470 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010629 | negative regulation of gene expression | IDA | 28124060 |
GO:0035195 | gene silencing by miRNA | IMP | 25085941 |
GO:0048147 | negative regulation of fibroblast proliferation | IMP | 25085941 |
GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | IDA | 28124060 |
GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | IDA | 28124060 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00006A5ABA_9606 | precursor_RNA | 81 | 6 |
HGNC: 32084, RefSeq: NR_030174, Ensembl: ENST00000349529 (view in UCSC) , miRBase: MI0003134, Rfam: RF00641, |
URS000075CDF9_9606 | miRNA | 23 | 4 |
RefSeq: NR_030174, miRBase: MIMAT0026607, MirGeneDB: Hsa-Mir-154-P18_5p, ENA: LM609464.1:15..37:ncRNA, |
URS0000535FDD_9606 | miRNA | 22 | 4 |
RefSeq: NR_030174, miRBase: MIMAT0002816, TarBase: hsa-miR-494-3p, |
URS0000031935_9606 | miRNA | 23 | 2 |
MirGeneDB: Hsa-Mir-154-P18_3p, ENA: AY785935.1:1..23:ncRNA, |
URS0000EFE1FA_9606 | precursor_RNA | 57 | 1 |
MirGeneDB: Hsa-Mir-154-P18, |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-494 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-494 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir494 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-494 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3635521 | CNV | gain | 21293372 |
esv3635523 | CNV | gain | 21293372 |
nsv1040993 | CNV | gain | 25217958 |
nsv1426 | CNV | insertion | 18451855 |
nsv565859 | CNV | gain | 21841781 |
nsv565860 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lymphoplasmacytic lymphoma |
|
|
heart disease |
|
|
retinoblastoma |
|
|
pancreatitis, hereditary |
|
|
primary biliary cirrhosis |
|