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MIR494 Gene(RNA Gene)

MicroRNA 494

GCID:
GC14P103227
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR494 Gene

Subcategory (RNA class) for MIR494 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR494 Gene

  • MicroRNA 494 2 3 5
  • Hsa-Mir-494 3
  • Mir-494 3
  • MIRN494 3

External Ids for MIR494 Gene

ORGUL Members for MIR494 Gene

Previous HGNC Symbols for MIR494 Gene

  • MIRN494

Previous GeneCards Identifiers for MIR494 Gene

  • GC14P100820
  • GC14P100911
  • GC14P101503
  • GC14P101564
  • GC14P101597
  • GC14P101610
  • GC14P101639
  • GC14P101671
  • GC14P101710
  • GC14P101751
  • GC14P101809
  • GC14P101949
  • GC14P102140
  • GC14P101242
  • GC14P101850
  • GC14P102103
  • GC14P102337
  • GC14P102509
  • GC14P102689
  • GC14P102857
  • GC14P103033

Summaries for MIR494 Gene

Entrez Gene Summary for MIR494 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR494 Gene

MIR494 (MicroRNA 494) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR494 include Waldenstrom Macroglobulinemia and Pancreatitis, Hereditary. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR494 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR494 Gene

Genomics for MIR494 Gene

Products:

  1. Regulatory Element

Genomic Locations for MIR494 Gene

Genomic Locations for MIR494 Gene
chr14:101,029,634-101,029,714
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr14:101,495,971-101,496,051
(GRCh37/hg19)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR494 Gene

Genes around MIR494 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR494 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR494 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR494 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR494 Gene

Proteins for MIR494 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR494 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR494 Gene

Domains & Families for MIR494 Gene

Gene Families for MIR494 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR494: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR494 Gene

Function for MIR494 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25085941
genes like me logo Genes that share ontologies with MIR494: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR494 Gene

Localization for MIR494 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR494 Gene

Pathways & Interactions for MIR494 Gene

SuperPathways for MIR494 Gene

PathCards logo More details on SuperPathways for MIR494
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR494: view

Pathways by source for MIR494 Gene

1 KEGG pathway for MIR494 Gene

Interacting Proteins for MIR494 Gene

Gene Ontology (GO) - Biological Process for MIR494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 28124060
GO:0035195 gene silencing by miRNA IMP 25085941
GO:0048147 negative regulation of fibroblast proliferation IMP 25085941
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 28124060
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA 28124060
genes like me logo Genes that share ontologies with MIR494: view

No data available for SIGNOR curated interactions for MIR494 Gene

Drugs & Compounds for MIR494 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR494 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR494 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR494 Gene

No ASD Table

Relevant External Links for MIR494 Gene

GeneLoc Exon Structure for
MIR494
ECgene alternative splicing isoforms for
MIR494

Expression for MIR494 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR494 Gene

mRNA expression in normal human tissues for MIR494 Gene
mRNA expression by GTEx for MIR494 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR494 Gene:

MIR494
genes like me logo Genes that share expression patterns with MIR494: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR494 Gene

Orthologs for MIR494 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR494 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-494 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-494 34
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir494 34
  • 94 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-494 34
  • 93 (a)
 OneToOne
Species where no ortholog for MIR494 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR494 Gene

ENSEMBL:
Gene Tree for MIR494 (if available)
TreeFam:
Gene Tree for MIR494 (if available)

Paralogs for MIR494 Gene

No data available for Paralogs for MIR494 Gene

Variants for MIR494 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR494 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000534079 -- 101,027,870(+) T/A upstream_transcript_variant
rs1001218964 -- 101,029,491(+) G/A/C upstream_transcript_variant
rs1002207888 -- 101,029,005(+) A/G upstream_transcript_variant
rs1002427291 -- 101,028,812(+) T/C upstream_transcript_variant
rs1002486330 -- 101,028,301(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR494 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR494 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR494

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR494 Gene

Disorders for MIR494 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR494 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
waldenstrom macroglobulinemia
  • lymphoplasmacytic lymphoma
pancreatitis, hereditary
  • pctt
primary biliary cirrhosis
  • biliary liver cirrhosis
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
heart disease
  • congestive heart failure
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR494

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR494: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR494 Gene

Publications for MIR494 Gene

  1. MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells. (PMID: 27696394) Tian C … Zhang Y (Journal of cellular physiology 2017) 3 58
  2. MicroRNA‑494 inhibits nerve growth factor‑induced cell proliferation by targeting cyclin D1 in human corneal epithelial cells. (PMID: 28765880) Wu D … Xu J (Molecular medicine reports 2017) 3 58
  3. Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494. (PMID: 28650977) Verma JK … Mukhopadhyay A (PLoS pathogens 2017) 3 58
  4. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. (PMID: 28533480) Salati S … Manfredini R (Oncotarget 2017) 3 58
  5. Prognostic significance of altered miRNA expression in whole blood of OSCC patients. (PMID: 28498442) Ries J … Nkenke E (Oncology reports 2017) 3 58

Products for MIR494 Gene

Sources for MIR494 Gene

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