microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR494 Gene

Subcategory (RNA class) for MIR494 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR494 Gene

  • MicroRNA 494 2 3 5
  • Hsa-Mir-494 2 3
  • MIR494 2 5
  • Hsa-Mir-154-P18 178
  • Hsa-MiR-494-3p 173
  • MIMAT0026607 50
  • MIMAT0002816 50
  • MI0003134 50
  • MIRN494 3
  • Mir-494 3
  • RF00641 168

External Ids for MIR494 Gene

Previous HGNC Symbols for MIR494 Gene

  • MIRN494

Previous GeneCards Identifiers for MIR494 Gene

  • GC14P100820
  • GC14P100911
  • GC14P101503
  • GC14P101564
  • GC14P101597
  • GC14P101610
  • GC14P101639
  • GC14P101671
  • GC14P101710
  • GC14P101751
  • GC14P101809
  • GC14P101949
  • GC14P102140
  • GC14P101242
  • GC14P101850
  • GC14P103635
  • GC14P103853
  • GC14P104130
  • GC14P104471
  • GC14P102103
  • GC14P102337
  • GC14P102509
  • GC14P102689
  • GC14P102857
  • GC14P103033
  • GC14P103227
  • GC14P103452

Summaries for MIR494 Gene

Entrez Gene Summary for MIR494 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR494 Gene

MIR494 (MicroRNA 494) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR494 include Lymphoplasmacytic Lymphoma and Heart Disease. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR494 Gene

Additional gene information for MIR494 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR494 Gene

Genomics for MIR494 Gene

Genomic Locations for MIR494 Gene

Genomic Locations for MIR494 Gene
chr14:101,029,634-101,029,714
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr14:101,495,971-101,496,051
(GRCh37/hg19)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR494 Gene

Genes around MIR494 on UCSC Golden Path with GeneCards custom track
MIR494 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR494 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR494 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR494 Gene

Proteins for MIR494 Gene

Post-translational modifications for MIR494 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR494 Gene

Domains & Families for MIR494 Gene

Gene Families for MIR494 Gene

genes like me logo Genes that share domains with MIR494: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR494 Gene

Function for MIR494 Gene

Gene Ontology (GO) - Molecular Function for MIR494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25085941
genes like me logo Genes that share ontologies with MIR494: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR494 Gene

Localization for MIR494 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR494 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR494: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR494 Gene

Pathways & Interactions for MIR494 Gene

PathCards logo

SuperPathways for MIR494 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR494: view

Pathways by source for MIR494 Gene

1 KEGG pathway for MIR494 Gene

Gene Ontology (GO) - Biological Process for MIR494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 28124060
GO:0035195 gene silencing by miRNA IMP 25085941
GO:0048147 negative regulation of fibroblast proliferation IMP 25085941
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 28124060
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA 28124060
genes like me logo Genes that share ontologies with MIR494: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR494 Gene

Drugs & Compounds for MIR494 Gene

No Compound Related Data Available

Transcripts for MIR494 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR494 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006A5ABA_9606 precursor_RNA 81 6

HGNC: 32084,

RefSeq: NR_030174,

Ensembl: ENST00000349529 (view in UCSC) ,

miRBase: MI0003134,

Rfam: RF00641,

ENA: LM609464.1:1..81:precursor_RNA,

URS000075CDF9_9606 miRNA 23 4

RefSeq: NR_030174,

miRBase: MIMAT0026607,

MirGeneDB: Hsa-Mir-154-P18_5p,

ENA: LM609464.1:15..37:ncRNA,

URS0000535FDD_9606 miRNA 22 4

RefSeq: NR_030174,

miRBase: MIMAT0002816,

TarBase: hsa-miR-494-3p,

ENA: LM379773.1:1..22:ncRNA, LM609464.1:48..69:ncRNA,

URS0000031935_9606 miRNA 23 2

MirGeneDB: Hsa-Mir-154-P18_3p,

ENA: AY785935.1:1..23:ncRNA,

URS0000EFE1FA_9606 precursor_RNA 57 1

MirGeneDB: Hsa-Mir-154-P18,

MIR494 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR494 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR494 Gene

No ASD Table

Relevant External Links for MIR494 Gene

GeneLoc Exon Structure for
MIR494

Expression for MIR494 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR494 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR494

Evidence on tissue expression from TISSUES for MIR494 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR494: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR494 Gene

Orthologs for MIR494 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR494 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-494 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-494 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir494 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-494 31
  • 93 (a)
OneToOne
Species where no ortholog for MIR494 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR494 Gene

ENSEMBL:
Gene Tree for MIR494 (if available)
TreeFam:
Gene Tree for MIR494 (if available)

Paralogs for MIR494 Gene

No data available for Paralogs for MIR494 Gene

Variants for MIR494 Gene

Additional dbSNP identifiers (rs#s) for MIR494 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR494 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR494 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR494

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR494 Gene

Disorders for MIR494 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR494 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lymphoplasmacytic lymphoma
  • waldenstrom macroglobulinemia
heart disease
  • congenital heart disease
retinoblastoma
  • rb1
pancreatitis, hereditary
  • cp
primary biliary cirrhosis
  • pbc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR494

genes like me logo Genes that share disorders with MIR494: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR494 Gene

Publications for MIR494 Gene

  1. miR‑494‑3p promotes the progression of endometrial cancer by regulating the PTEN/PI3K/AKT pathway. (PMID: 30431102) Zhu L … Zhou X (Molecular medicine reports 2019) 3
  2. miR‑494.3p expression in synovial sarcoma: Role of CXCR4 as a potential target gene. (PMID: 30431073) Pazzaglia L … Benassi MS (International journal of oncology 2019) 3
  3. Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer. (PMID: 31686763) Wan BS … Zhang L (World journal of gastroenterology 2019) 3
  4. Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN. (PMID: 31228937) Lu Q … Guo H (Molecular cancer 2019) 3
  5. Expression patterns and prognostic value of miR-210, miR-494, and miR-205 in middle-aged and old patients with sepsis-induced acute kidney injury. (PMID: 30997877) Lin Y … Guo F (Bosnian journal of basic medical sciences 2019) 3

Products for MIR494 Gene

Sources for MIR494 Gene