Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR493 Gene

Subcategory (RNA class) for MIR493 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR493 Gene

  • MicroRNA 493 2 3 5
  • Hsa-Mir-493 3
  • Mir-493 3
  • MIRN493 3

External Ids for MIR493 Gene

ORGUL Members for MIR493 Gene

Previous HGNC Symbols for MIR493 Gene

  • MIRN493

Previous GeneCards Identifiers for MIR493 Gene

  • GC14P100406
  • GC14P101335
  • GC14P101216
  • GC14P101797
  • GC14P102090
  • GC14P102325
  • GC14P102495
  • GC14P102671
  • GC14P102843
  • GC14P103016

Summaries for MIR493 Gene

Entrez Gene Summary for MIR493 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR493 Gene

MIR493 (MicroRNA 493) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR493 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR493 Gene

Genomics for MIR493 Gene

GeneHancer (GH) Regulatory Elements for MIR493 Gene

Promoters and enhancers for MIR493 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100819 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -42.5 -42524 13.4 ELF3 PKNOX1 FOXA2 ZSCAN4 NFXL1 ZNF48 RAD21 RFX5 ZNF280A SLC30A9 ENSG00000274884 DLK1 MEG3 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433 RTL1
GH14J100691 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -175.6 -175643 4.1 FOXA2 MLX SIN3A ZNF48 ETS1 YY1 GLIS2 ZNF143 FOS SP5 DLK1 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 LINC00523 LOC105370668
GH14J100486 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -382.6 -382621 0.6 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF143 ATF7 RUNX3 JUNB MXD4 RN7SKP92 MIR337 MIR127 MIR136 MIR433 RTL1 MIR431 MIR493 GC14P103466 GC14M100431
GH14J100657 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 -204.5 -204549 13.4 ATF1 FOXA2 ARID4B DMAP1 ZNF2 ZNF48 ZNF143 ATF7 FOS RXRA LOC105370667 DLK1 WARS WDR25 BEGAIN MEG9 MIR493 MIR337 MIR127 MIR431
GH14J100416 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -451.6 -451632 2.2 HDGF PKNOX1 SIN3A RAD21 RFX5 ZNF143 RCOR1 FOS ATF7 CREM WARS WDR25 BEGAIN MIR337 MIR493 MIR431 MIR433 MIR127 MIR136 RTL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR493 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR493 Gene

Genomic Locations for MIR493 Gene
chr14:100,869,060-100,869,148
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr14:101,335,397-101,335,485
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR493 Gene

Genes around MIR493 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR493 Gene

Proteins for MIR493 Gene

Post-translational modifications for MIR493 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR493 Gene

Domains & Families for MIR493 Gene

Gene Families for MIR493 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR493: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR493 Gene

Function for MIR493 Gene

Phenotypes From GWAS Catalog for MIR493 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR493 Gene

Localization for MIR493 Gene

Gene Ontology (GO) - Cellular Components for MIR493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR493: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR493 Gene

Pathways & Interactions for MIR493 Gene

SuperPathways for MIR493 Gene

No Data Available

Interacting Proteins for MIR493 Gene

Gene Ontology (GO) - Biological Process for MIR493 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR493 Gene

Drugs & Compounds for MIR493 Gene

No Compound Related Data Available

Transcripts for MIR493 Gene

mRNA/cDNA for MIR493 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR493 Gene

No ASD Table

Relevant External Links for MIR493 Gene

GeneLoc Exon Structure for
MIR493
ECgene alternative splicing isoforms for
MIR493

Expression for MIR493 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR493 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR493 Gene:

MIR493
genes like me logo Genes that share expression patterns with MIR493: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR493 Gene

Orthologs for MIR493 Gene

Evolution for MIR493 Gene

ENSEMBL:
Gene Tree for MIR493 (if available)
TreeFam:
Gene Tree for MIR493 (if available)

No data available for Orthologs for MIR493 Gene

Paralogs for MIR493 Gene

No data available for Paralogs for MIR493 Gene

Variants for MIR493 Gene

Sequence variations from dbSNP and Humsavar for MIR493 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001231010 -- 100,867,292(+) G/T upstream_transcript_variant
rs1002881347 -- 100,868,180(+) G/A upstream_transcript_variant
rs1004535040 -- 100,867,265(+) T/C upstream_transcript_variant
rs1005060089 -- 100,867,063(+) G/C upstream_transcript_variant
rs1005244253 -- 100,869,268(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR493 Gene

Variant ID Type Subtype PubMed ID
nsv509549 CNV insertion 20534489
esv3635518 CNV gain 21293372
esv2456141 CNV deletion 19546169

Additional Variant Information for MIR493 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR493 Gene

Disorders for MIR493 Gene

Additional Disease Information for MIR493

No disorders were found for MIR493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR493 Gene

Publications for MIR493 Gene

  1. Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis. (PMID: 27956702) Kumar AS … Rayala SK (Molecular and cellular biology 2017) 3 58
  2. miR-493-5p suppresses hepatocellular carcinoma cell proliferation through targeting GP73. (PMID: 28419971) Zhao J … Chen L (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  3. High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1. (PMID: 28537888) Liang Z … Ma YS (Oncotarget 2017) 3 58
  4. MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2). (PMID: 28651234) Xu Y … Huang Q (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  5. Downregulation of miR-493 promoted melanoma proliferation by suppressing IRS4 expression. (PMID: 28475006) Cui A … An Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR493 Gene

Sources for MIR493 Gene

Content
Loading form....