microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR493 Gene

Subcategory (RNA class) for MIR493 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR493 Gene

  • MIMAT0002813 50
  • MIMAT0003161 50
  • MI0003132 50
  • MIRN493 3
  • Mir-493 3

External Ids for MIR493 Gene

Previous HGNC Symbols for MIR493 Gene

  • MIRN493

Previous GeneCards Identifiers for MIR493 Gene

  • GC14P100406
  • GC14P101335
  • GC14P101216
  • GC14P101797
  • GC14P103634
  • GC14P103852
  • GC14P104127
  • GC14P104470
  • GC14P102090
  • GC14P102325
  • GC14P102495
  • GC14P102671
  • GC14P102843
  • GC14P103016
  • GC14P103214
  • GC14P103451

Summaries for MIR493 Gene

Entrez Gene Summary for MIR493 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR493 Gene

MIR493 (MicroRNA 493) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR493 include Leiomyoma, Uterine and Nemaline Myopathy.

Additional gene information for MIR493 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR493 Gene

Genomics for MIR493 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR493 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR493 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR493 Gene

Genomic Locations for MIR493 Gene
chr14:100,869,060-100,869,148
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr14:101,335,397-101,335,485
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR493 Gene

Genes around MIR493 on UCSC Golden Path with GeneCards custom track
MIR493 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR493 Gene

Proteins for MIR493 Gene

Post-translational modifications for MIR493 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR493 Gene

Domains & Families for MIR493 Gene

Gene Families for MIR493 Gene

HGNC:
genes like me logo Genes that share domains with MIR493: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR493 Gene

Function for MIR493 Gene

Phenotypes From GWAS Catalog for MIR493 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR493 Gene

Localization for MIR493 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR493 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR493 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR493: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR493 Gene

Pathways & Interactions for MIR493 Gene

PathCards logo

SuperPathways for MIR493 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR493 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR493 Gene

Drugs & Compounds for MIR493 Gene

No Compound Related Data Available

Transcripts for MIR493 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR493 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000077AED_9606 miRNA 22 6

RefSeq: NR_030172,

LncBase: hsa-miR-493-5p,

miRBase: MIMAT0002813,

MirGeneDB: Hsa-Mir-493_5p,

TarBase: hsa-miR-493-5p,

ENA: AY940861.1:1..22:ncRNA, LM379771.1:1..22:ncRNA, LM609462.1:16..37:ncRNA,

URS000075C9D6_9606 precursor_RNA 89 5

HGNC: 32082,

RefSeq: NR_030172,

Ensembl: ENST00000385254 (view in UCSC) ,

miRBase: MI0003132,

ENA: LM609462.1:1..89:precursor_RNA,

URS00005E7CB2_9606 miRNA 22 5

RefSeq: NR_030172,

LncBase: hsa-miR-493-3p,

miRBase: MIMAT0003161,

TarBase: hsa-miR-493-3p,

ENA: LM379833.1:1..22:ncRNA, LM609462.1:57..78:ncRNA,

URS0000EFE155_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-493,

URS000075AECC_9606 miRNA 21 1

MirGeneDB: Hsa-Mir-493_3p,

MIR493 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR493 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR493 Gene

No ASD Table

Relevant External Links for MIR493 Gene

GeneLoc Exon Structure for
MIR493

Expression for MIR493 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR493 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR493

genes like me logo Genes that share expression patterns with MIR493: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR493 Gene

Orthologs for MIR493 Gene

Evolution for MIR493 Gene

ENSEMBL:
Gene Tree for MIR493 (if available)
TreeFam:
Gene Tree for MIR493 (if available)

No data available for Orthologs for MIR493 Gene

Paralogs for MIR493 Gene

No data available for Paralogs for MIR493 Gene

Variants for MIR493 Gene

Additional dbSNP identifiers (rs#s) for MIR493 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR493 Gene

Variant ID Type Subtype PubMed ID
esv2456141 CNV deletion 19546169
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Additional Variant Information for MIR493 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR493

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR493 Gene

Disorders for MIR493 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR493 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR493

genes like me logo Genes that share disorders with MIR493: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR493 Gene

Publications for MIR493 Gene

  1. MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion. (PMID: 31883160) Yasukawa K … Gailhouste L (Cancer science 2020) 3
  2. miR-493 Promotes Prostate Cancer Cells Proliferation by Targeting PHLPP2 and Activating Akt Signaling Pathway. (PMID: 30868840) Deng J … Cui S (Clinical laboratory 2019) 3
  3. MicroRNA-493-5p inhibits proliferation and metastasis of osteosarcoma cells by targeting Kruppel-like factor 5. (PMID: 30773645) Zhang Z … Shi X (Journal of cellular physiology 2019) 3
  4. A four serum-miRNA panel serves as a potential diagnostic biomarker of osteosarcoma. (PMID: 31111286) Huang C … Jin C (International journal of clinical oncology 2019) 3
  5. MicroRNA-493 targets STMN-1 and promotes hypoxia-induced epithelial cell cycle arrest in G2/M and renal fibrosis. (PMID: 30183377) Liu T … Sun S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3

Products for MIR493 Gene

Sources for MIR493 Gene