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Aliases for MIR489 Gene

Subcategory (RNA class) for MIR489 Gene

miRNA

Quality Score for this RNA gene is

18

Aliases for MIR489 Gene

  • MicroRNA 489 2 3 5
  • Hsa-Mir-489 3
  • Mir-489 3
  • MIRN489 3

External Ids for MIR489 Gene

Previous HGNC Symbols for MIR489 Gene

  • MIRN489

Previous GeneCards Identifiers for MIR489 Gene

  • GC07M092953
  • GC07M093114
  • GC07M093116
  • GC07M093118

Summaries for MIR489 Gene

Entrez Gene Summary for MIR489 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR489 Gene

MIR489 (MicroRNA 489) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR489 include Hypopharynx Cancer.

fRNAdb sequence ontologies for MIR489 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR489

Additional gene information for MIR489 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR489 Gene

Genomics for MIR489 Gene

GeneHancer (GH) Regulatory Elements for MIR489 Gene

Promoters and enhancers for MIR489 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J093558 Enhancer 0.6 Ensembl 9.9 -75.5 -75482 1.4 ATF1 NR2F1 ATF2 ZNF335 JUND ZNF692 CREB1 ATF7 KLF13 MIR489 MIR653 HEPACAM2 CALCR LOC105375400
GH07J093486 Enhancer 0.2 dbSUPER 0.7 -2.6 -2578 1.1 MIR489 LOC105375400 CALCR
GH07J093487 Enhancer 0.2 dbSUPER 0.7 -3.5 -3514 0.8 MIR489 LOC105375400 CALCR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR489 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR489 Gene

Genomic Locations for MIR489 Gene
chr7:93,483,936-93,484,019
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr7:93,113,248-93,113,331
(GRCh37/hg19)
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR489 Gene

Genes around MIR489 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR489 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR489 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR489 Gene

ORGUL Member Location for MIR489 Gene

ORGUL Member Location for MIR489 gene

Proteins for MIR489 Gene

Post-translational modifications for MIR489 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR489 Gene

Domains & Families for MIR489 Gene

Gene Families for MIR489 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR489: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR489 Gene

Function for MIR489 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR489 Gene

Localization for MIR489 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR489 Gene

Pathways & Interactions for MIR489 Gene

SuperPathways for MIR489 Gene

No Data Available

Interacting Proteins for MIR489 Gene

Gene Ontology (GO) - Biological Process for MIR489 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR489 Gene

Drugs & Compounds for MIR489 Gene

No Compound Related Data Available

Transcripts for MIR489 Gene

fRNAdb Secondary structures for MIR489 Gene

  • hsa-mir-489_MI0003124_Homo_sapiens_miR-489_stem-loop_hairpin

mRNA/cDNA for MIR489 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR489 Gene

No ASD Table

Relevant External Links for MIR489 Gene

GeneLoc Exon Structure for
MIR489
ECgene alternative splicing isoforms for
MIR489

Expression for MIR489 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR489 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR489 Gene:

MIR489
genes like me logo Genes that share expression patterns with MIR489: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR489 Gene

Orthologs for MIR489 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR489 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-489 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-489 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-489 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir489 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-489 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-489 34
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-489 34
  • 69 (a)
OneToOne
Species where no ortholog for MIR489 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR489 Gene

ENSEMBL:
Gene Tree for MIR489 (if available)
TreeFam:
Gene Tree for MIR489 (if available)

Paralogs for MIR489 Gene

No data available for Paralogs for MIR489 Gene

Variants for MIR489 Gene

Sequence variations from dbSNP and Humsavar for MIR489 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1002195425 -- 93,485,421(-) G/A upstream_transcript_variant
rs1002565194 -- 93,483,686(-) G/A downstream_transcript_variant
rs1002612697 -- 93,484,192(-) C/A upstream_transcript_variant
rs1003566000 -- 93,485,409(-) A/G upstream_transcript_variant
rs1003619626 -- 93,485,755(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR489 Gene

Variant ID Type Subtype PubMed ID
nsv607815 CNV loss 21841781

Additional Variant Information for MIR489 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR489

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR489 Gene

Disorders for MIR489 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR489 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
hypopharynx cancer
  • hypopharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR489

genes like me logo Genes that share disorders with MIR489: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR489 Gene

Publications for MIR489 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I … Bentwich Z (Nature genetics 2005) 1 3 58
  2. Inhibition of proliferation and invasion of hepatocellular carcinoma cells by lncRNA-ASLNC02525 silencing and the mechanism. (PMID: 28713968) Chen Z … Zhang T (International journal of oncology 2017) 3 58
  3. miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K/AKT pathway. (PMID: 28666210) Li Y … Li G (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  4. LncRNA CHRF-induced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway. (PMID: 28430582) Tao Y … Sun C (Oncotarget 2017) 3 58
  5. Loss of MicroRNA-489-3p promotes osteosarcoma metastasis by activating PAX3-MET pathway. (PMID: 27859625) Liu Q … Qian Y (Molecular carcinogenesis 2017) 3 58

Products for MIR489 Gene

Sources for MIR489 Gene

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