microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR488 Gene

Subcategory (RNA class) for MIR488 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR488 Gene

  • MIMAT0002804 50
  • MIMAT0004763 50
  • MI0003123 50
  • MIRN488 3
  • Mir-488 3
  • RF00861 168

External Ids for MIR488 Gene

Previous HGNC Symbols for MIR488 Gene

  • MIRN488

Previous GeneCards Identifiers for MIR488 Gene

  • GC01M175266
  • GC01M176998

Summaries for MIR488 Gene

Entrez Gene Summary for MIR488 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR488 Gene

MIR488 (MicroRNA 488) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR488 include Panic Disorder. Among its related pathways are Alzheimers Disease.

Rfam classification for MIR488 Gene

Additional gene information for MIR488 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR488 Gene

Genomics for MIR488 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR488 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J176997 Enhancer 0.5 Ensembl 10.9 +32.7 32744 1 ZIC2 ZNF341 TCF7L2 MYC RCOR1 YY1 CHD2 GATA2 JUND MIR488 ASTN1 lnc-COP1-8 lnc-COP1-7 PAPPA2
GH01J177065 Enhancer 0.5 Ensembl 11.4 -36.3 -36256 0.6 TEAD4 ZIC2 MAFK ZNF189 GLIS1 MIR488 ASTN1 piR-45035-014 PAPPA2
GH01J176995 Enhancer 0.4 FANTOM5 10.9 +34.3 34254 0.1 RCOR1 GATA2 ASTN1 MIR488 lnc-COP1-8 lnc-COP1-7 PAPPA2
GH01J176903 Enhancer 0.3 Ensembl CraniofacialAtlas 9.7 +125.3 125344 1.8 ASTN1 BRINP2 MIR488 lnc-COP1-7 lnc-BRINP2-3 PAPPA2
GH01J177067 Enhancer 0.3 Ensembl 11.4 -38.7 -38656 1 SMARCA4 MIR488 ASTN1 BRINP2 piR-45035-014 PAPPA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR488 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR488 Gene

Genomic Locations for MIR488 Gene
chr1:177,029,363-177,029,445
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand
chr1:176,998,499-176,998,581
(GRCh37/hg19)
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR488 Gene

Genes around MIR488 on UCSC Golden Path with GeneCards custom track
MIR488 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR488 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR488 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR488 Gene

Proteins for MIR488 Gene

Post-translational modifications for MIR488 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR488 Gene

Domains & Families for MIR488 Gene

Gene Families for MIR488 Gene

HGNC:
genes like me logo Genes that share domains with MIR488: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR488 Gene

Function for MIR488 Gene

Gene Ontology (GO) - Molecular Function for MIR488 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28915828
genes like me logo Genes that share ontologies with MIR488: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR488 Gene

Localization for MIR488 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR488 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR488 Gene

Pathways & Interactions for MIR488 Gene

PathCards logo

SuperPathways for MIR488 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR488: view

Pathways by source for MIR488 Gene

1 BioSystems pathway for MIR488 Gene

Gene Ontology (GO) - Biological Process for MIR488 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process IDA 28915828
GO:0045415 negative regulation of interleukin-8 biosynthetic process IDA 28915828
GO:0050724 negative regulation of interleukin-1 beta biosynthetic process IDA 28915828
GO:0050728 negative regulation of inflammatory response IDA 28915828
genes like me logo Genes that share ontologies with MIR488: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR488 Gene

Drugs & Compounds for MIR488 Gene

No Compound Related Data Available

Transcripts for MIR488 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR488 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000072C8C2_9606 precursor_RNA 83 6

HGNC: 32073,

RefSeq: NR_030163,

Ensembl: ENST00000365739 (view in UCSC) ,

miRBase: MI0003123,

Rfam: RF00861,

ENA: LM609455.1:1..83:precursor_RNA,

URS00001BCAC5_9606 miRNA 21 6

RefSeq: NR_030163,

LncBase: hsa-miR-488-3p,

miRBase: MIMAT0004763,

MirGeneDB: Hsa-Mir-488_3p,

TarBase: hsa-miR-488-3p,

ENA: AY940877.1:1..21:ncRNA, LM380380.1:1..21:ncRNA, LM609455.1:52..72:ncRNA,

URS00002A36ED_9606 miRNA 21 5

RefSeq: NR_030163,

LncBase: hsa-miR-488-5p,

miRBase: MIMAT0002804,

TarBase: hsa-miR-488-5p,

ENA: AY940876.1:1..21:ncRNA, LM609455.1:14..34:ncRNA,

URS0000EFBC60_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-488,

URS000076F07B_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-488_5p,

MIR488 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR488 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR488 Gene

No ASD Table

Relevant External Links for MIR488 Gene

GeneLoc Exon Structure for
MIR488

Expression for MIR488 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR488

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR488 Gene

Orthologs for MIR488 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR488 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-488 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-488 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-488 31
  • 81 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir488 31
  • 71 (a)
OneToOne
Species where no ortholog for MIR488 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR488 Gene

ENSEMBL:
Gene Tree for MIR488 (if available)
TreeFam:
Gene Tree for MIR488 (if available)

Paralogs for MIR488 Gene

No data available for Paralogs for MIR488 Gene

Variants for MIR488 Gene

Additional dbSNP identifiers (rs#s) for MIR488 Gene

Additional Variant Information for MIR488 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR488

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR488 Gene

Disorders for MIR488 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR488 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
panic disorder
  • panic disorder 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR488

genes like me logo Genes that share disorders with MIR488: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR488 Gene

Publications for MIR488 Gene

  1. Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease. (PMID: 30443988) Wen Z … Tang W (Journal of cellular physiology 2019) 3
  2. MicroRNA-488 inhibits progression of colorectal cancer via inhibition of the mitogen-activated protein kinase pathway by targeting claudin-2. (PMID: 30207785) Wang YB … Qiu W (American journal of physiology. Cell physiology 2019) 3
  3. PYCR1 promotes the progression of non-small-cell lung cancer under the negative regulation of miR-488. (PMID: 30605882) Wang D … Chen G (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  4. Downregulated microRNA-488 enhances odontoblast differentiation of human dental pulp stem cells via activation of the p38 MAPK signaling pathway. (PMID: 30132853) Yu D … Han GH (Journal of cellular physiology 2019) 3
  5. MicroRNA-488 inhibits proliferation and glycolysis in human prostate cancer cells by regulating PFKFB3. (PMID: 31410981) Wang J … Wen X (FEBS open bio 2019) 3

Products for MIR488 Gene

Sources for MIR488 Gene