microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR486-2 Gene

Subcategory (RNA class) for MIR486-2 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR486-2 Gene

  • MicroRNA 486-2 2 3 5
  • Hsa-MiR-486-5p 166 177
  • Hsa-MiR-486-3p 166 177
  • MicroRNA Mir-486-2 3
  • Hsa-Mir-486-2 3
  • MIMAT0004762 51
  • MIMAT0002177 51
  • Mir-486-2 3
  • MI0023622 51
  • MIR486-2 2

External Ids for MIR486-2 Gene

Previous GeneCards Identifiers for MIR486-2 Gene

  • GC08U901876
  • GC08P041663
  • GC08P041664
  • GC08P041683
  • GC08P041689
  • GC08P041681
  • GC08P041666
  • GC08P041668
  • GC08P041670
  • GC08P041673
  • GC08P041675
  • GC08P041677

Summaries for MIR486-2 Gene

Entrez Gene Summary for MIR486-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR486-2 Gene

MIR486-2 (MicroRNA 486-2) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR486-2 Gene

Additional gene information for MIR486-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR486-2 Gene

Genomics for MIR486-2 Gene

GeneHancer (GH) Regulatory Elements for MIR486-2 Gene

Promoters and enhancers for MIR486-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J041659 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +2.8 2809 8.2 ZIC2 ZNF423 REST ZNF341 OSR2 TCF12 POLR2A ZNF316 MAFF CTCF ANK1 GINS4 ENSG00000253389 MIR486-1 MIR486-2 lnc-NKX6-3-3 RF00017-6993
GH08J041653 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 0.4 -5.3 -5330 3.4 GABPA MAFF MYNN POLR2G PHF8 ZFHX2 PTBP1 SUPT5H FOXP2 NRF1 NKX6-3 MIR486-2 RF00017-6993 ANK1
GH08J041652 Promoter/Enhancer 0.7 CraniofacialAtlas dbSUPER 0.4 -7.3 -7262 0.2 SUZ12 EZH2 NKX6-3 MIR486-2 RF00017-6993 ANK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR486-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR486-2 Gene

Genomic Locations for MIR486-2 Gene
chr8:41,660,444-41,660,507
(GRCh38/hg38)
Size:
64 bases
Orientation:
Plus strand

Genomic View for MIR486-2 Gene

Genes around MIR486-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR486-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR486-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR486-2 Gene

Proteins for MIR486-2 Gene

Post-translational modifications for MIR486-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR486-2 Gene

Domains & Families for MIR486-2 Gene

Gene Families for MIR486-2 Gene

genes like me logo Genes that share domains with MIR486-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR486-2 Gene

Function for MIR486-2 Gene

Phenotypes From GWAS Catalog for MIR486-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR486-2 Gene

Localization for MIR486-2 Gene

Gene Ontology (GO) - Cellular Components for MIR486-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR486-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR486-2 Gene

Pathways & Interactions for MIR486-2 Gene

PathCards logo

SuperPathways for MIR486-2 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR486-2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR486-2 Gene

Drugs & Compounds for MIR486-2 Gene

No Compound Related Data Available

Transcripts for MIR486-2 Gene

mRNA/cDNA for MIR486-2 Gene

3 RNACentral transcripts :
2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
7 ENA transcripts :
2 LncBase transcripts :
2 TarBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR486-2 Gene

No ASD Table

Relevant External Links for MIR486-2 Gene

GeneLoc Exon Structure for
MIR486-2

Expression for MIR486-2 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR486-2 Gene

Orthologs for MIR486-2 Gene

Evolution for MIR486-2 Gene

ENSEMBL:
Gene Tree for MIR486-2 (if available)
TreeFam:
Gene Tree for MIR486-2 (if available)

No data available for Orthologs for MIR486-2 Gene

Paralogs for MIR486-2 Gene

No data available for Paralogs for MIR486-2 Gene

Variants for MIR486-2 Gene

Additional dbSNP identifiers (rs#s) for MIR486-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR486-2 Gene

Variant ID Type Subtype PubMed ID
esv3576565 CNV gain 25503493
nsv831299 CNV loss 17160897

Additional Variant Information for MIR486-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR486-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR486-2 Gene

Disorders for MIR486-2 Gene

Additional Disease Information for MIR486-2

No disorders were found for MIR486-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR486-2 Gene

Publications for MIR486-2 Gene

  1. MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1. (PMID: 31253192) Chou ST … Shiah SG (Journal of experimental & clinical cancer research : CR 2019) 3 54
  2. MicroRNA‑486‑5p functions as a tumor suppressor of proliferation and cancer stem‑like cell properties by targeting Sirt1 in liver cancer. (PMID: 30569158) Yan X … Pei X (Oncology reports 2019) 3 54
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 54
  4. miR-486-5p expression pattern in esophageal squamous cell carcinoma, gastric cancer and its prognostic value. (PMID: 26895105) Ren C … Han D (Oncotarget 2016) 3 54
  5. MYB controls erythroid versus megakaryocyte lineage fate decision through the miR-486-3p-mediated downregulation of MAF. (PMID: 25857263) Bianchi E … Manfredini R (Cell death and differentiation 2015) 3 54

Products for MIR486-2 Gene

Sources for MIR486-2 Gene