microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR486-1 Gene

Data sources for MIR486-1 Gene:

RNA type for MIR486-1 Gene

miRNA

Aliases for MIR486-1 Gene

External Ids for MIR486-1 Gene

Previous HGNC Symbols for MIR486-1 Gene

  • MIRN486
  • MIR486

Summaries for MIR486-1 Gene

Entrez Gene Summary for MIR486-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR486-1 Gene

MIR486-1 (MicroRNA 486-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR486-1 include Lung Cancer and Muscular Dystrophy, Duchenne Type.

Rfam classification for MIR486-1 Gene

Additional gene information for MIR486-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR486-1 Gene

Genomics for MIR486-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR486-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J041659 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.7 -2745 8.2 ZIC2 ZNF341 MAFF ZNF316 CTCF BHLHE40 SPI1 MAFK REST IKZF1 ANK1 GINS4 ENSG00000253389 MIR486-1 MIR486-2 lnc-NKX6-3-3 NKX6-3 RF00017-6441
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR486-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR486-1 Gene

Latest Assembly
chr8:41,660,441-41,660,508
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand

Previous Assembly
chr8:41,517,959-41,518,026
(GRCh37/hg19 by Entrez Gene)
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR486-1 Gene

Genes around MIR486-1 on UCSC Golden Path with GeneCards custom track
MIR486-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR486-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR486-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR486-1 Gene

Proteins for MIR486-1 Gene

Post-translational modifications for MIR486-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR486-1 Gene

Domains & Families for MIR486-1 Gene

Gene Families for MIR486-1 Gene

genes like me logo Genes that share domains with MIR486-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR486-1 Gene

Function for MIR486-1 Gene

Phenotypes From GWAS Catalog for MIR486-1 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR486-1 Gene

Localization for MIR486-1 Gene

Gene Ontology (GO) - Cellular Components for MIR486-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR486-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR486-1 Gene

Pathways & Interactions for MIR486-1 Gene

PathCards logo

SuperPathways for MIR486-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR486-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR486-1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR486-1 Gene

Drugs & Compounds for MIR486-1 Gene

No Compound Related Data Available

Transcripts for MIR486-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR486-1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004BF1DC_9606 miRNA 22 6

RefSeq: NR_030161, NR_106984,

LncBase: hsa-miR-486-5p,

miRBase: MIMAT0002177,

MirGeneDB: Hsa-Mir-486_5p,

TarBase: hsa-miR-486-5p,

ENA: LM379711.1:1..22:ncRNA, LM609404.1:4..25:ncRNA, LM611805.1:1..22:ncRNA,

URS000071BDB0_9606 pre_miRNA 68 5

RefSeq: NR_030161,

Ensembl: ENST00000612171 (view in UCSC) ,

miRBase: MI0002470,

Rfam: RF00784,

ENA: LM609404.1:1..68:precursor_RNA,

URS0000377E71_9606 miRNA 21 5

RefSeq: NR_030161, NR_106984,

LncBase: hsa-miR-486-3p,

miRBase: MIMAT0004762,

TarBase: hsa-miR-486-3p,

ENA: LM380379.1:1..21:ncRNA, LM609404.1:46..66:ncRNA, LM611805.1:43..63:ncRNA,

URS0001BC1C8B_9606 pre_miRNA 68 1

Rfam: RF00784,

URS0000EFE77A_9606 pre_miRNA 65 1

MirGeneDB: Hsa-Mir-486,

MIR486-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR486-1 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR486-1 Gene

No ASD Table

Relevant External Links for MIR486-1 Gene

GeneLoc Exon Structure for
MIR486-1

Expression for MIR486-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR486-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR486-1

genes like me logo Genes that share expression patterns with MIR486-1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR486-1 Gene

Orthologs for MIR486-1 Gene

Evolution for MIR486-1 Gene

ENSEMBL:
Gene Tree for MIR486-1 (if available)
TreeFam:
Gene Tree for MIR486-1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR486-1

No data available for Orthologs for MIR486-1 Gene

Paralogs for MIR486-1 Gene

No data available for Paralogs for MIR486-1 Gene

Variants for MIR486-1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR486-1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR486-1 Gene

Variant ID Type Subtype PubMed ID
esv3576565 CNV gain 25503493
nsv831299 CNV loss 17160897

Additional Variant Information for MIR486-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR486-1
Leiden Open Variation Database (LOVD)
MIR486-1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR486-1 Gene

Disorders for MIR486-1 Gene

MalaCards: The human disease database

(88) MalaCards diseases for MIR486-1 Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR486-1

genes like me logo Genes that share disorders with MIR486-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR486-1 Gene

Publications for MIR486-1 Gene

  1. Circ-TCF4.85 silencing inhibits cancer progression through microRNA-486-5p-targeted inhibition of ABCF2 in hepatocellular carcinoma. (PMID: 31758671) Gao J … Zhou F (Molecular oncology 2020) 3
  2. A Sox2:miR-486-5p Axis Regulates Survival of GBM Cells by Inhibiting Tumor Suppressor Networks. (PMID: 32094299) Lopez-Bertoni H … Laterra J (Cancer research 2020) 3
  3. Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p. (PMID: 32492708) Chen L … Xiao H (The Journal of clinical endocrinology and metabolism 2020) 3
  4. Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node. (PMID: 33059532) Petkova M … Dobrzynski H (Journal of the American Heart Association 2020) 3
  5. The differential expression of miRNAs between ovarian endometrioma and endometriosis-associated ovarian cancer. (PMID: 32359364) Nakamura N … Ohmichi M (Journal of ovarian research 2020) 3

Products for MIR486-1 Gene

Sources for MIR486-1 Gene