microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR485 Gene

Subcategory (RNA class) for MIR485 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR485 Gene

  • MicroRNA 485 2 3 5
  • Hsa-MiR-485-3p 163 173
  • Hsa-MiR-485-5p 163 173
  • Hsa-Mir-485 2 3
  • MIR485 2 5
  • Hsa-Mir-154-P15 178
  • MIMAT0002175 50
  • MIMAT0002176 50
  • MI0002469 50
  • MIRN485 3
  • Mir-485 3
  • RF00641 168

External Ids for MIR485 Gene

Previous HGNC Symbols for MIR485 Gene

  • MIRN485

Previous GeneCards Identifiers for MIR485 Gene

  • GC14P100834
  • GC14P100924
  • GC14P101525
  • GC14P101554
  • GC14P101589
  • GC14P101628
  • GC14P101656
  • GC14P101690
  • GC14P101728
  • GC14P101768
  • GC14P101826
  • GC14P101966
  • GC14P102163
  • GC14P101267
  • GC14P101876
  • GC14P103631
  • GC14P103848
  • GC14P104124
  • GC14P104467
  • GC14P102199
  • GC14P102367
  • GC14P102537
  • GC14P102716
  • GC14P102889
  • GC14P103062
  • GC14P103260
  • GC14P103448

Summaries for MIR485 Gene

Entrez Gene Summary for MIR485 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR485 Gene

MIR485 (MicroRNA 485) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR485 include Anxiety and Muscular Dystrophy, Duchenne Type. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR485 Gene

Additional gene information for MIR485 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR485 Gene

Genomics for MIR485 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR485 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101056 Enhancer 0.3 Ensembl 600.7 +1.1 1085 0.2 FOS CTCF MIR134 MIR323B MIR485 MIR668 MIR154 RTL1 DIO3
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11 +42.9 42851 3.3 ATF7 KDM1A SPI1 ATF4 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101232 Enhancer 0.9 Ensembl CraniofacialAtlas 9.6 +178.7 178684 3.4 HNRNPL GATAD2A CTCF ZIC2 ZSCAN4 RXRB REST RAD21 MNT SMARCA5 MIR370 MIR655 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR1185-1 MIR300
GH14J101004 Enhancer 0.6 ENCODE CraniofacialAtlas 11 -50.3 -50331 1.9 MNT SPI1 TCF7L2 MYC MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14J101176 Enhancer 0.6 Ensembl ENCODE 10.7 +122.0 121950 2 RCOR1 ZFP3 CHD2 ZNF680 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-3 SNORD113-2 ENSG00000222185
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR485 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR485 Gene

Genomic Locations for MIR485 Gene
chr14:101,055,416-101,055,494
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr14:101,521,738-101,521,848
(GRCh37/hg19)
Size:
111 bases
Orientation:
Plus strand

Genomic View for MIR485 Gene

Genes around MIR485 on UCSC Golden Path with GeneCards custom track
MIR485 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR485 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR485 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR485 Gene

Proteins for MIR485 Gene

Post-translational modifications for MIR485 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR485 Gene

Domains & Families for MIR485 Gene

Gene Families for MIR485 Gene

HGNC:
genes like me logo Genes that share domains with MIR485: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR485 Gene

Function for MIR485 Gene

Gene Ontology (GO) - Molecular Function for MIR485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25910754
genes like me logo Genes that share ontologies with MIR485: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR485 Gene

Localization for MIR485 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR485 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR485: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR485 Gene

Pathways & Interactions for MIR485 Gene

PathCards logo

SuperPathways for MIR485 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR485: view

Pathways by source for MIR485 Gene

1 BioSystems pathway for MIR485 Gene

Gene Ontology (GO) - Biological Process for MIR485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0060546 negative regulation of necroptotic process IDA 25910754
genes like me logo Genes that share ontologies with MIR485: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR485 Gene

Drugs & Compounds for MIR485 Gene

No Compound Related Data Available

Transcripts for MIR485 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR485 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000006372A_9606 miRNA 22 6

RefSeq: NR_030160,

LncBase: hsa-miR-485-3p,

miRBase: MIMAT0002176,

MirGeneDB: Hsa-Mir-154-P15_3p,

TarBase: hsa-miR-485-3p,

ENA: AY882307.1:1..22:ncRNA, LM379710.1:1..22:ncRNA, LM609403.1:46..67:ncRNA,

URS000075D081_9606 precursor_RNA 73 5

HGNC: 32067,

RefSeq: NR_030160,

Ensembl: ENST00000385292 (view in UCSC) ,

miRBase: MI0002469,

ENA: LM609403.1:1..73:precursor_RNA,

URS00001935FA_9606 miRNA 22 5

RefSeq: NR_030160,

LncBase: hsa-miR-485-5p,

miRBase: MIMAT0002175,

TarBase: hsa-miR-485-5p,

ENA: AY882335.1:1..22:ncRNA, LM379709.1:1..22:ncRNA, LM609403.1:9..30:ncRNA,

URS000072B1BC_9606 precursor_RNA 79 1

Rfam: RF00641,

URS0000EFE4B1_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-154-P15,

MIR485 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR485 Gene

3 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR485 Gene

No ASD Table

Relevant External Links for MIR485 Gene

GeneLoc Exon Structure for
MIR485

Expression for MIR485 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR485 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR485

genes like me logo Genes that share expression patterns with MIR485: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR485 Gene

Orthologs for MIR485 Gene

Evolution for MIR485 Gene

ENSEMBL:
Gene Tree for MIR485 (if available)
TreeFam:
Gene Tree for MIR485 (if available)

No data available for Orthologs for MIR485 Gene

Paralogs for MIR485 Gene

No data available for Paralogs for MIR485 Gene

Variants for MIR485 Gene

Additional dbSNP identifiers (rs#s) for MIR485 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR485 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR485 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR485

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR485 Gene

Disorders for MIR485 Gene

MalaCards: The human disease database

(25) MalaCards diseases for MIR485 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
anxiety
  • anxiety disorder
muscular dystrophy, duchenne type
  • dmd
ovarian cancer
  • ovarian cancer, somatic
social phobia
  • phobia social
skeletal muscle cancer
  • malignant tumor of skeletal muscle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR485

genes like me logo Genes that share disorders with MIR485: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR485 Gene

Publications for MIR485 Gene

  1. Long noncoding RNA BLACAT1 is overexpressed in hepatocellular carcinoma and its downregulation suppressed cancer cell development through endogenously competing against hsa-miR-485-5p. (PMID: 31174090) Peng Y … Hong M (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  2. MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2. (PMID: 30836864) Gao F … Liu J (Bioengineered 2019) 3
  3. MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus. (PMID: 30130620) Solé C … Cortés-Hernández J (The Journal of investigative dermatology 2019) 3
  4. microRNA‑485 inhibits the malignant behaviors of retinoblastoma by directly targeting Wnt3a. (PMID: 30896857) Lyu X … Wang L (Oncology reports 2019) 3
  5. Potential Regulation of UGT2B10 and UGT2B7 by miR-485-5p in Human Liver. (PMID: 31554697) Sutliff AK … Lazarus P (Molecular pharmacology 2019) 3

Products for MIR485 Gene

Sources for MIR485 Gene