microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR484 Gene

Subcategory (RNA class) for MIR484 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR484 Gene

  • MicroRNA 484 2 3 5
  • Hsa-Mir-484 2 3
  • Hsa-MiR-484 163 173
  • MIR484 2 5
  • MIMAT0002174 50
  • MI0002468 50
  • MIRN484 3
  • Mir-484 3
  • RF00783 168

External Ids for MIR484 Gene

Previous HGNC Symbols for MIR484 Gene

  • MIRN484

Previous GeneCards Identifiers for MIR484 Gene

  • GC16P015645
  • GC16P015737
  • GC16P015646
  • GC16P015665
  • GC16P015669
  • GC16P015662
  • GC16P015660
  • GC16P015652
  • GC16P015655

Summaries for MIR484 Gene

Entrez Gene Summary for MIR484 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR484 Gene

MIR484 (MicroRNA 484) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR484 include Autism Spectrum Disorder and Systemic Lupus Erythematosus. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition.

Rfam classification for MIR484 Gene

Additional gene information for MIR484 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR484 Gene

Genomics for MIR484 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR484 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J015638 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -0.3 -307 9 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 LEF1 SOX13 MARF1 NDE1 MIR484 ENSG00000263335 PDXDC1 PKD1P3 PKD1P1 LOC100505915 PKD1P6 ABCC1
GH16J015648 Enhancer 0.3 ENCODE 0.4 +5.0 5025 0.2 ZNF133 piR-50444-143 NDE1 MIR484 MYH11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR484 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR484 Gene

Genomic Locations for MIR484 Gene
chr16:15,643,294-15,643,372
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr16:15,737,151-15,737,229
(GRCh37/hg19)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR484 Gene

Genes around MIR484 on UCSC Golden Path with GeneCards custom track
MIR484 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR484 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR484 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR484 Gene

Proteins for MIR484 Gene

Post-translational modifications for MIR484 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR484 Gene

Domains & Families for MIR484 Gene

Gene Families for MIR484 Gene

HGNC:
genes like me logo Genes that share domains with MIR484: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR484 Gene

Function for MIR484 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR484 Gene

Localization for MIR484 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR484 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR484: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR484 Gene

Pathways & Interactions for MIR484 Gene

genes like me logo Genes that share pathways with MIR484: view

Gene Ontology (GO) - Biological Process for MIR484 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR484: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR484 Gene

Drugs & Compounds for MIR484 Gene

No Compound Related Data Available

Transcripts for MIR484 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR484 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00005651EE_9606 precursor_RNA 79 5

HGNC: 32341,

RefSeq: NR_030159,

Ensembl: ENST00000606601 (view in UCSC) ,

miRBase: MI0002468,

ENA: HI397483.1:1..79:misc_RNA, LM609402.1:1..79:precursor_RNA,

URS0000597BED_9606 miRNA 22 5

RefSeq: NR_030159,

LncBase: hsa-miR-484,

miRBase: MIMAT0002174,

TarBase: hsa-miR-484,

ENA: LM379708.1:1..22:ncRNA, LM609402.1:8..29:ncRNA,

URS000066D160_9606 precursor_RNA 67 1

Rfam: RF00783,

MIR484 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR484 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR484 Gene

No ASD Table

Relevant External Links for MIR484 Gene

GeneLoc Exon Structure for
MIR484

Expression for MIR484 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR484 Gene

genes like me logo Genes that share expression patterns with MIR484: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR484 Gene

Orthologs for MIR484 Gene

Evolution for MIR484 Gene

ENSEMBL:
Gene Tree for MIR484 (if available)
TreeFam:
Gene Tree for MIR484 (if available)

No data available for Orthologs for MIR484 Gene

Paralogs for MIR484 Gene

No data available for Paralogs for MIR484 Gene

Variants for MIR484 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR484 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
884574 Uncertain Significance: Lissencephaly 4 15,643,299(+) C/T NON_CODING_TRANSCRIPT_VARIANT
884575 Uncertain Significance: Lissencephaly 4 15,643,328(+) C/T NON_CODING_TRANSCRIPT_VARIANT
rs376603273 Likely Benign: Lissencephaly 4 15,643,320(+) G/A NON_CODING_TRANSCRIPT_VARIANT
rs757090627 Uncertain Significance: Lissencephaly, Recessive 15,643,346(+) C/CG NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MIR484 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR484 Gene

Variant ID Type Subtype PubMed ID
dgv4924n54 CNV gain 21841781
esv2714015 CNV deletion 23290073
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv469626 CNV loss 16826518

Additional Variant Information for MIR484 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR484

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR484 Gene

Disorders for MIR484 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR484 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR484

genes like me logo Genes that share disorders with MIR484: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR484 Gene

Publications for MIR484 Gene

  1. miRNAs 484 and 210 regulate Pax-5 expression and function in breast cancer cells. (PMID: 30605519) Harquail J … Robichaud GA (Carcinogenesis 2019) 3
  2. Dysregulation of miR484-TUSC5 axis takes part in the progression of hepatocellular carcinoma. (PMID: 31157375) Wang S … Tan Z (Journal of biochemistry 2019) 3
  3. Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. (PMID: 31182601) Gongol B … Shyy JY (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
  4. Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma. (PMID: 30537115) Qiu L … Liu J (Molecular oncology 2019) 3
  5. LncRNA H19 promotes epithelial-mesenchymal transition (EMT) by targeting miR-484 in human lung cancer cells. (PMID: 29219208) Zhang Q … Chen Z (Journal of cellular biochemistry 2018) 3

Products for MIR484 Gene

Sources for MIR484 Gene