microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR483 Gene

Subcategory (RNA class) for MIR483 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR483 Gene

  • MIMAT0004761 50
  • MIMAT0002173 50
  • MI0002467 50
  • MIRN483 3
  • Mir-483 3

External Ids for MIR483 Gene

Previous HGNC Symbols for MIR483 Gene

  • MIRN483

Previous GeneCards Identifiers for MIR483 Gene

  • GC11M002115
  • GC11M002117
  • GC11M002155
  • GC11M002136
  • GC11M002138
  • GC11M002168
  • GC11M002170
  • GC11M002169
  • GC11M002178
  • GC11M002139
  • GC11M002146
  • GC11M002148
  • GC11M002154
  • GC11M002157
  • GC11M002160
  • GC11M002162
  • GC11M002166

Summaries for MIR483 Gene

Entrez Gene Summary for MIR483 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR483 Gene

MIR483 (MicroRNA 483) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR483 include Adrenocortical Carcinoma, Hereditary and Pancreatic Cancer. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR483 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR483 Gene

Genomics for MIR483 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR483 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002095 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 12.2 +37.4 37400 3.6 HNRNPL GATAD2A TEAD4 KDM1A RCOR2 RBFOX2 RXRB IRF2 SP1 EZH2 HSALNG0082189 MIR483 IGF2-AS IGF2 HSALNG0082191 MRPL23
GH11J002108 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 12.6 +24.8 24808 1.6 HNRNPL GATAD2A RBFOX2 RXRB RNF2 MBD1 TFDP1 SAP130 GABPB1 ZGPAT MIR483 IGF2-AS IGF2 TNNT3 TH piR-42694-026 HSALNG0082191 MRPL23
GH11J002175 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -41.9 -41891 1.4 MNT CREB1 MAX MAFK PAX8 KDM1A TH IGF2 IGF2-AS MIR483 ASCL2 KRTAP5-6 HSALNG0082199
GH11J002178 Enhancer 1 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 11.3 -44.9 -44862 0.6 ZSCAN4 MNT PKNOX1 FOS HSALNG0082199 IGF2 TH IGF2-AS MIR483 ENSG00000236710 ASCL2 SYT8
GH11J002216 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 11.5 -83.0 -82992 2.4 HNRNPL ZSCAN4 REST MNT CTCF MAX SAP130 GABPB1 RAD21 KLF1 ASCL2 TSPAN32 IGF2 IGF2-AS MIR483 CD81 ENSG00000199550 TRPM5 lnc-TH-1 piR-38351-062
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR483 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR483 Gene

Genomic Locations for MIR483 Gene
chr11:2,134,134-2,134,209
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr11:2,155,364-2,155,439
(GRCh37/hg19)
Size:
76 bases
Orientation:
Minus strand

Genomic View for MIR483 Gene

Genes around MIR483 on UCSC Golden Path with GeneCards custom track
MIR483 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR483 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR483 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR483 Gene

Proteins for MIR483 Gene

Post-translational modifications for MIR483 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR483 Gene

Domains & Families for MIR483 Gene

Gene Families for MIR483 Gene

HGNC:
genes like me logo Genes that share domains with MIR483: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR483 Gene

Function for MIR483 Gene

Phenotypes From GWAS Catalog for MIR483 Gene

Gene Ontology (GO) - Molecular Function for MIR483 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21893058
genes like me logo Genes that share ontologies with MIR483: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR483 Gene

Localization for MIR483 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR483 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR483 Gene

Pathways & Interactions for MIR483 Gene

PathCards logo

SuperPathways for MIR483 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR483: view

Pathways by source for MIR483 Gene

1 KEGG pathway for MIR483 Gene

Gene Ontology (GO) - Biological Process for MIR483 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 22223106
GO:0035278 miRNA mediated inhibition of translation IDA 21893058
GO:0045599 negative regulation of fat cell differentiation ISS --
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP 21893058
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP 21893058
genes like me logo Genes that share ontologies with MIR483: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR483 Gene

Drugs & Compounds for MIR483 Gene

No Compound Related Data Available

Transcripts for MIR483 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR483 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000003575B_9606 miRNA 22 6

RefSeq: NR_030158,

LncBase: hsa-miR-483-5p,

miRBase: MIMAT0004761,

MirGeneDB: Hsa-Mir-483_5p,

TarBase: hsa-miR-483-5p,

ENA: LM380378.1:1..22:ncRNA, LM609401.1:8..29:ncRNA,

URS000018B0EE_9606 precursor_RNA 76 5

HGNC: 32340,

RefSeq: NR_030158,

Ensembl: ENST00000385070 (view in UCSC) ,

miRBase: MI0002467,

ENA: HI397481.1:1..76:misc_RNA, LM609401.1:1..76:precursor_RNA,

URS00000EA063_9606 miRNA 21 5

RefSeq: NR_030158,

LncBase: hsa-miR-483-3p,

miRBase: MIMAT0002173,

TarBase: hsa-miR-483-3p,

ENA: LM379707.1:1..21:ncRNA, LM609401.1:48..68:ncRNA,

URS0000EFDDA3_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-483,

URS00007E3F24_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-483_3p,

MIR483 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR483 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR483 Gene

No ASD Table

Relevant External Links for MIR483 Gene

GeneLoc Exon Structure for
MIR483

Expression for MIR483 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR483 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR483

genes like me logo Genes that share expression patterns with MIR483: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR483 Gene

Orthologs for MIR483 Gene

Evolution for MIR483 Gene

ENSEMBL:
Gene Tree for MIR483 (if available)
TreeFam:
Gene Tree for MIR483 (if available)

No data available for Orthologs for MIR483 Gene

Paralogs for MIR483 Gene

No data available for Paralogs for MIR483 Gene

Variants for MIR483 Gene

Additional dbSNP identifiers (rs#s) for MIR483 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR483 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv825707 CNV gain 20364138
nsv951284 CNV deletion 24416366

Additional Variant Information for MIR483 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR483

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR483 Gene

Disorders for MIR483 Gene

MalaCards: The human disease database

(113) MalaCards diseases for MIR483 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
adrenocortical carcinoma, hereditary
  • adcc
pancreatic cancer
  • pancreatic carcinoma
mesothelioma, malignant
  • mesom
adrenal cortex disease
  • adrenal cortex diseases
adrenal gland disease
  • adrenal gland disorders
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR483

genes like me logo Genes that share disorders with MIR483: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR483 Gene

Publications for MIR483 Gene

  1. Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner. (PMID: 21146586) Ma N … Gao X (Molecular and cellular endocrinology 2011) 2 3
  2. Upregulation of DKK3 by miR-483-3p plays an important role in the chemoprevention of colorectal cancer mediated by black raspberry anthocyanins. (PMID: 31763724) Guo J … Bi X (Molecular carcinogenesis 2020) 3
  3. MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in human colorectal cancer cells. (PMID: 30861353) Liang H … Dai P (Artificial cells, nanomedicine, and biotechnology 2019) 3
  4. Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells. (PMID: 30602302) Fernandez Esmerats J … Jo H (Arteriosclerosis, thrombosis, and vascular biology 2019) 3
  5. Serum miR-483-5p and miR-133a as Biomarkers for Diagnosis of Hepatocellular Carcinoma Post-Hepatitis C Infection in Egyptian Patients. (PMID: 31926493) Hassan AS … Elnasser AM (The Egyptian journal of immunology 2019) 3

Products for MIR483 Gene

Sources for MIR483 Gene