microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4786 Gene

Data sources for MIR4786 Gene:

Subcategory (RNA class) for MIR4786 Gene

miRNA

Aliases for MIR4786 Gene

External Ids for MIR4786 Gene

Previous GeneCards Identifiers for MIR4786 Gene

  • GC02U902412
  • GC02M240885

Summaries for MIR4786 Gene

Entrez Gene Summary for MIR4786 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4786 Gene

MIR4786 (MicroRNA 4786) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4786 include Spinocerebellar Ataxia 6.

Additional gene information for MIR4786 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4786 Gene

Genomics for MIR4786 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4786 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J239937 Enhancer 0.6 FANTOM5 dbSUPER 0.4 +5.8 5769 0.3 CEBPG CEBPB HSALNG0023543 MIR4786 NDUFA10 LOC401040
GH02J239936 Enhancer 0.5 FANTOM5 dbSUPER 0.4 +6.9 6893 0.1 CEBPG HSALNG0023543 NDUFA10 MIR4786 LOC401040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4786 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4786 Gene

Latest Assembly
chr2:239,943,015-239,943,094
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand

Previous Assembly
chr2:240,882,432-240,882,511
(GRCh37/hg19 by Entrez Gene)
Size:
80 bases
Orientation:
Minus strand

chr2:240,882,432-240,882,511
(GRCh37/hg19 by Ensembl)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR4786 Gene

Genes around MIR4786 on UCSC Golden Path with GeneCards custom track
MIR4786 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4786 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4786 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4786 Gene

Proteins for MIR4786 Gene

Post-translational modifications for MIR4786 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4786 Gene

Domains & Families for MIR4786 Gene

Gene Families for MIR4786 Gene

HGNC:
genes like me logo Genes that share domains with MIR4786: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4786 Gene

Function for MIR4786 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4786 Gene

Localization for MIR4786 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4786 Gene

Pathways & Interactions for MIR4786 Gene

PathCards logo

SuperPathways for MIR4786 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4786 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4786 Gene

Drugs & Compounds for MIR4786 Gene

No Compound Related Data Available

Transcripts for MIR4786 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4786 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000078918_9606 miRNA 22 5

RefSeq: NR_039949,

LncBase: hsa-miR-4786-3p,

miRBase: MIMAT0019955,

TarBase: hsa-miR-4786-3p,

ENA: FR773106.1:1..22:ncRNA, LM611421.1:51..72:ncRNA,

URS000075B733_9606 precursor_RNA 80 4

RefSeq: NR_039949,

Ensembl: ENST00000583954 (view in UCSC) ,

miRBase: MI0017433,

ENA: LM611421.1:1..80:precursor_RNA,

URS000023BDD3_9606 miRNA 22 3

RefSeq: NR_039949,

miRBase: MIMAT0019954,

ENA: FR773107.1:1..22:ncRNA, LM382590.1:1..22:ncRNA, LM611421.1:11..32:ncRNA,

MIR4786 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4786 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4786 Gene

No ASD Table

Relevant External Links for MIR4786 Gene

GeneLoc Exon Structure for
MIR4786

Expression for MIR4786 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4786 Gene

genes like me logo Genes that share expression patterns with MIR4786: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4786 Gene

Orthologs for MIR4786 Gene

Evolution for MIR4786 Gene

ENSEMBL:
Gene Tree for MIR4786 (if available)
TreeFam:
Gene Tree for MIR4786 (if available)

No data available for Orthologs for MIR4786 Gene

Paralogs for MIR4786 Gene

No data available for Paralogs for MIR4786 Gene

Variants for MIR4786 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4786 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4786 Gene

Variant ID Type Subtype PubMed ID
nsv3235 CNV insertion 18451855
nsv834584 CNV gain 17160897
nsv997288 CNV gain 25217958

Additional Variant Information for MIR4786 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4786

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4786 Gene

Disorders for MIR4786 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4786 Gene - From: COP

Disorder Aliases PubMed IDs
spinocerebellar ataxia 6
  • sca6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4786

genes like me logo Genes that share disorders with MIR4786: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4786 Gene

Publications for MIR4786 Gene

  1. A 3-miRNA signature predicts prognosis of pediatric and adolescent cytogenetically normal acute myeloid leukemia. (PMID: 28473658) Zhu R … Hu Y (Oncotarget 2017) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4786 Gene

Sources for MIR4786 Gene