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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4786 (MicroRNA 4786) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J239926 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +15.3 | 15285 | 2.4 | CREB1 ATF7 ZNF629 RFX1 ZNF692 JUND ZIC2 PATZ1 ZNF600 EP300 | NDUFA10 OR6B3 HSALNG0023541 MIR4786 LOC401040 | |
GH02J239934 | Enhancer | 0.9 | ENCODE dbSUPER | 0.4 | +8.4 | 8395 | 0.2 | CTCF TFE3 NFKBIZ PHF21A PKNOX1 POLR2A RAD21 NFE2 TGIF2 ZNF316 | NDUFA10 MIR4786 HSALNG0023541 LOC401040 | |
GH02J239937 | Enhancer | 0.6 | FANTOM5 dbSUPER | 0.4 | +5.8 | 5769 | 0.3 | CEBPB CEBPG | MIR4786 HSALNG0023541 NDUFA10 LOC401040 | |
GH02J239936 | Enhancer | 0.5 | FANTOM5 dbSUPER | 0.4 | +6.9 | 6893 | 0.1 | CEBPG | NDUFA10 MIR4786 HSALNG0023541 LOC401040 | |
GH02J239929 | Enhancer | 0.5 | FANTOM5 dbSUPER | 0.4 | +13.9 | 13856 | 0.4 | CTCF RAD21 | MIR4786 HSALNG0023541 NDUFA10 LOC401040 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075B733_9606 | precursor_RNA | 80 | 5 |
HGNC: 41751, RefSeq: NR_039949, Ensembl: ENST00000583954 (view in UCSC) , miRBase: MI0017433, |
URS0000078918_9606 | miRNA | 22 | 5 |
RefSeq: NR_039949, LncBase: hsa-miR-4786-3p, miRBase: MIMAT0019955, TarBase: hsa-miR-4786-3p, |
URS000023BDD3_9606 | miRNA | 22 | 3 |
RefSeq: NR_039949, miRBase: MIMAT0019954, ENA: FR773107.1:1..22:ncRNA, LM382590.1:1..22:ncRNA, LM611421.1:11..32:ncRNA, |
No disorders were found for MIR4786 Gene.