microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4761 Gene

Subcategory (RNA class) for MIR4761 Gene

miRNA

Number of RNA Genes sources:

2 / 14

Aliases for MIR4761 Gene

  • MicroRNA 4761 2 3 5
  • Hsa-Mir-4761 3
  • MIMAT0019909 51
  • MIMAT0019908 51
  • MI0017402 51
  • MIR4761 2

External Ids for MIR4761 Gene

Previous GeneCards Identifiers for MIR4761 Gene

  • GC22U900800
  • GC22P019976
  • GC22P019984
  • GC22P019992

Summaries for MIR4761 Gene

Entrez Gene Summary for MIR4761 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4761 Gene

MIR4761 (MicroRNA 4761) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Dopamine metabolism and Metabolism.

Additional gene information for MIR4761 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4761 Gene

Genomics for MIR4761 Gene

GeneHancer (GH) Regulatory Elements for MIR4761 Gene

Promoters and enhancers for MIR4761 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4761 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4761 Gene

Genomic Locations for MIR4761 Gene
chr22:19,963,753-19,963,834
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr22:19,951,276-19,951,357
(GRCh37/hg19)
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR4761 Gene

Genes around MIR4761 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4761 Gene

Proteins for MIR4761 Gene

Post-translational modifications for MIR4761 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4761 Gene

Domains & Families for MIR4761 Gene

Gene Families for MIR4761 Gene

HGNC:
genes like me logo Genes that share domains with MIR4761: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4761 Gene

Function for MIR4761 Gene

Phenotypes From GWAS Catalog for MIR4761 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4761 Gene

Localization for MIR4761 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4761 Gene

Pathways & Interactions for MIR4761 Gene

genes like me logo Genes that share pathways with MIR4761: view
;

Gene Ontology (GO) - Biological Process for MIR4761 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4761 Gene

Drugs & Compounds for MIR4761 Gene

No Compound Related Data Available

Transcripts for MIR4761 Gene

mRNA/cDNA for MIR4761 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
2 ENA transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4761 Gene

No ASD Table

Relevant External Links for MIR4761 Gene

GeneLoc Exon Structure for
MIR4761

Expression for MIR4761 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4761 Gene

genes like me logo Genes that share expression patterns with MIR4761: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4761 Gene

Orthologs for MIR4761 Gene

Evolution for MIR4761 Gene

ENSEMBL:
Gene Tree for MIR4761 (if available)
TreeFam:
Gene Tree for MIR4761 (if available)

No data available for Orthologs for MIR4761 Gene

Paralogs for MIR4761 Gene

No data available for Paralogs for MIR4761 Gene

Variants for MIR4761 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR4761 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
749686 Likely Benign: not provided 19,963,767(+) T/C NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR4761 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4761 Gene

Variant ID Type Subtype PubMed ID
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
esv3568271 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3584493 CNV gain 24956385
esv3893434 CNV gain 25118596
nsv1055752 CNV gain 25217958
nsv1064496 CNV gain 25217958
nsv469641 CNV loss 16826518
nsv517165 CNV loss 19592680
nsv588240 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv953026 CNV deletion 24416366

Additional Variant Information for MIR4761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4761

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4761 Gene

Disorders for MIR4761 Gene

Additional Disease Information for MIR4761

No disorders were found for MIR4761 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4761 Gene

Publications for MIR4761 Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 54
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 54
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4761 Gene

Sources for MIR4761 Gene