microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4761 Gene

Subcategory (RNA class) for MIR4761 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4761 Gene

  • MicroRNA 4761 2 3 5
  • Hsa-Mir-4761 2 3
  • MIR4761 2 5
  • MIMAT0019908 50
  • MIMAT0019909 50
  • MI0017402 50

External Ids for MIR4761 Gene

Previous GeneCards Identifiers for MIR4761 Gene

  • GC22U900800
  • GC22P019976
  • GC22P019984
  • GC22P019992

Summaries for MIR4761 Gene

Entrez Gene Summary for MIR4761 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4761 Gene

MIR4761 (MicroRNA 4761) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Clearance In The Synaptic Cleft.

Additional gene information for MIR4761 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4761 Gene

Genomics for MIR4761 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4761 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J019958 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -2.3 -2265 6.4 HNRNPL GATAD2A CTCF PRDM10 REST TFE3 LEF1 IKZF1 NFKBIZ RCOR2 COMT NONHSAG033289.2 lnc-ARVCF-2 LINC01311 TRMT2A DGCR8 ENSG00000215493 RPL7AP70 DGCR11 MED15
GH22J019965 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 +5.0 5040 7.3 ARHGAP35 HNRNPL GATAD2A CTCF ATF7 ZNF629 IKZF1 NFKBIZ ZNF692 JUND RPL7AP70 DGCR8 TRMT2A RPL8P5 ENSG00000273300 MED15 ARVCF DGCR11 ENSG00000215493 LINC01311
GH22J019974 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +11.3 11258 3.2 ARHGAP35 ZBTB33 RFX1 IKZF1 RFX5 KDM1A JUND DDX20 MTA2 ZIC2 ARVCF ABHD17AP4 UFD1 COMT RPL7AP70 MN297902 MIR4761 TXNRD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4761 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4761 Gene

Genomic Locations for MIR4761 Gene
chr22:19,963,753-19,963,834
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr22:19,951,276-19,951,357
(GRCh37/hg19)
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR4761 Gene

Genes around MIR4761 on UCSC Golden Path with GeneCards custom track
MIR4761 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4761 Gene

Proteins for MIR4761 Gene

Post-translational modifications for MIR4761 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4761 Gene

Domains & Families for MIR4761 Gene

Gene Families for MIR4761 Gene

HGNC:
genes like me logo Genes that share domains with MIR4761: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4761 Gene

Function for MIR4761 Gene

Phenotypes From GWAS Catalog for MIR4761 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4761 Gene

Localization for MIR4761 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4761 Gene

Pathways & Interactions for MIR4761 Gene

genes like me logo Genes that share pathways with MIR4761: view

Gene Ontology (GO) - Biological Process for MIR4761 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4761 Gene

Drugs & Compounds for MIR4761 Gene

No Compound Related Data Available

Transcripts for MIR4761 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4761 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D5DB_9606 precursor_RNA 82 4

HGNC: 41591,

RefSeq: NR_039918,

Ensembl: ENST00000585066 (view in UCSC) ,

miRBase: MI0017402,

URS00002F924F_9606 miRNA 21 3

RefSeq: NR_039918,

miRBase: MIMAT0019908,

ENA: FR773065.1:1..21:ncRNA,

URS000046C832_9606 miRNA 21 3

RefSeq: NR_039918,

miRBase: MIMAT0019909,

ENA: FR773064.1:1..21:ncRNA,

MIR4761 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4761 Gene

No ASD Table

Relevant External Links for MIR4761 Gene

GeneLoc Exon Structure for
MIR4761

No data available for mRNA/cDNA for MIR4761 Gene

Expression for MIR4761 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4761 Gene

genes like me logo Genes that share expression patterns with MIR4761: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4761 Gene

Orthologs for MIR4761 Gene

Evolution for MIR4761 Gene

ENSEMBL:
Gene Tree for MIR4761 (if available)
TreeFam:
Gene Tree for MIR4761 (if available)

No data available for Orthologs for MIR4761 Gene

Paralogs for MIR4761 Gene

No data available for Paralogs for MIR4761 Gene

Variants for MIR4761 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR4761 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
749686 Likely Benign: not provided 19,963,767(+) T/C NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
828965 Drug Response: Tramadol response 19,963,756(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MIR4761 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4761 Gene

Variant ID Type Subtype PubMed ID
dgv72n68 CNV loss 17160897
dgv7983n54 CNV gain 21841781
esv3568271 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3584493 CNV gain 24956385
esv3893434 CNV gain 25118596
nsv1055752 CNV gain 25217958
nsv1064496 CNV gain 25217958
nsv469641 CNV loss 16826518
nsv517165 CNV loss 19592680
nsv588240 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv953026 CNV deletion 24416366

Additional Variant Information for MIR4761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4761

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4761 Gene

Disorders for MIR4761 Gene

Additional Disease Information for MIR4761

No disorders were found for MIR4761 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4761 Gene

Publications for MIR4761 Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4761 Gene

Sources for MIR4761 Gene