microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4758 Gene

Subcategory (RNA class) for MIR4758 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4758 Gene

  • MicroRNA 4758 2 3 5
  • Hsa-Mir-4758 2 3
  • MIR4758 2 5
  • MIMAT0019904 50
  • MIMAT0019903 50
  • MI0017399 50

External Ids for MIR4758 Gene

Previous GeneCards Identifiers for MIR4758 Gene

  • GC20U900689
  • GC20M060910
  • GC20M060912

Summaries for MIR4758 Gene

Entrez Gene Summary for MIR4758 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4758 Gene

MIR4758 (MicroRNA 4758) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and Degradation of the extracellular matrix.

Additional gene information for MIR4758 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4758 Gene

Genomics for MIR4758 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4758 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J062337 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -6.4 -6426 2.8 SP1 RELA RBFOX2 TCF12 IKZF2 POLR2A EED RELB RUNX3 GATAD2B LAMA5 MTG2 LAMA5-AS1 HE856191 MIR4758 ADRM1
GH20J062336 Enhancer 0.7 dbSUPER 0.7 -4.5 -4536 0.9 CREB1 ZBTB33 RFX1 TARDBP RBFOX2 TCF12 IKZF2 POLR2A MNT RUNX3 LAMA5 CABLES2 LAMA5-AS1 MIR4758 HE856191 ADRM1
GH20J062335 Enhancer 0.6 Ensembl dbSUPER 0.7 -3.2 -3244 1.6 HNRNPL RFX1 ZBTB10 BMI1 ZNF444 RFX5 ADRM1 LAMA5-AS1 LAMA5 MIR4758 HE856191
GH20J062343 Enhancer 0.6 ENCODE 0.4 -10.6 -10573 0 CEBPA SOX13 FOXA2 ZBTB40 ZNF205 RBM22 NFIC SAP130 NFIB SMAD4 HE856191 MIR4758 LAMA5 ADRM1
GH20J062344 Enhancer 0.4 ENCODE 0.4 -12.4 -12363 0.2 CEBPB FOXA2 BHLHE40 HE856191 LAMA5 RPS21 ENSG00000226332 ADRM1 MIR4758
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4758 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4758 Gene

Genomic Locations for MIR4758 Gene
chr20:62,332,487-62,332,557
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand
chr20:60,907,529-60,907,616
(GRCh37/hg19)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR4758 Gene

Genes around MIR4758 on UCSC Golden Path with GeneCards custom track
MIR4758 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4758 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4758 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4758 Gene

Proteins for MIR4758 Gene

Post-translational modifications for MIR4758 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4758 Gene

Domains & Families for MIR4758 Gene

Gene Families for MIR4758 Gene

HGNC:
genes like me logo Genes that share domains with MIR4758: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4758 Gene

Function for MIR4758 Gene

Phenotypes From GWAS Catalog for MIR4758 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4758 Gene

Localization for MIR4758 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4758 Gene

Pathways & Interactions for MIR4758 Gene

genes like me logo Genes that share pathways with MIR4758: view

Gene Ontology (GO) - Biological Process for MIR4758 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4758 Gene

Drugs & Compounds for MIR4758 Gene

No Compound Related Data Available

Transcripts for MIR4758 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4758 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D767_9606 precursor_RNA 71 4

HGNC: 41836,

RefSeq: NR_039915,

Ensembl: ENST00000577688 (view in UCSC) ,

miRBase: MI0017399,

URS0000031E74_9606 miRNA 23 3

RefSeq: NR_039915,

miRBase: MIMAT0019904,

ENA: FR773059.1:1..23:ncRNA,

URS0000378EED_9606 miRNA 23 3

RefSeq: NR_039915,

miRBase: MIMAT0019903,

ENA: FR773060.1:1..23:ncRNA,

MIR4758 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4758 Gene

No ASD Table

Relevant External Links for MIR4758 Gene

GeneLoc Exon Structure for
MIR4758

No data available for mRNA/cDNA for MIR4758 Gene

Expression for MIR4758 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4758 Gene

genes like me logo Genes that share expression patterns with MIR4758: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4758 Gene

Orthologs for MIR4758 Gene

Evolution for MIR4758 Gene

ENSEMBL:
Gene Tree for MIR4758 (if available)
TreeFam:
Gene Tree for MIR4758 (if available)

No data available for Orthologs for MIR4758 Gene

Paralogs for MIR4758 Gene

No data available for Paralogs for MIR4758 Gene

Variants for MIR4758 Gene

Additional dbSNP identifiers (rs#s) for MIR4758 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4758 Gene

Variant ID Type Subtype PubMed ID
dgv518n27 CNV loss 19166990
dgv7650n54 CNV loss 21841781
dgv7651n54 CNV loss 21841781
dgv7652n54 CNV loss 21841781
esv2422398 CNV duplication 17116639
nsv459059 CNV loss 19166990
nsv459065 CNV gain 19166990
nsv470556 CNV loss 18288195
nsv470557 CNV gain 18288195
nsv518296 CNV loss 19592680
nsv520024 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv817908 CNV loss 17921354
nsv834024 CNV gain 17160897
nsv953301 CNV deletion 24416366

Additional Variant Information for MIR4758 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4758

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4758 Gene

Disorders for MIR4758 Gene

Additional Disease Information for MIR4758

No disorders were found for MIR4758 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4758 Gene

Publications for MIR4758 Gene

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4758 Gene

Sources for MIR4758 Gene