microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4756 Gene

Subcategory (RNA class) for MIR4756 Gene

miRNA

Number of RNA Genes sources:

2 / 14

Aliases for MIR4756 Gene

  • MicroRNA 4756 2 3 5
  • Hsa-Mir-4756 3
  • MIMAT0019900 51
  • MIMAT0019899 51
  • MI0017397 51
  • MIR4756 2

External Ids for MIR4756 Gene

Previous GeneCards Identifiers for MIR4756 Gene

  • GC20U900698
  • GC20M052687

Summaries for MIR4756 Gene

Entrez Gene Summary for MIR4756 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4756 Gene

MIR4756 (MicroRNA 4756) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4756 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4756 Gene

Genomics for MIR4756 Gene

GeneHancer (GH) Regulatory Elements for MIR4756 Gene

Promoters and enhancers for MIR4756 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J054065 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 500.7 -0.1 -60 6 EP300 FOXK2 TCF12 NCOR1 BCLAF1 PHB2 KDM6A TCF7 FOXA1 TARDBP BCAS1 MIR4756 PFDN4
GH20J054063 Enhancer 0.8 ENCODE 0.7 +4.3 4257 1.4 RELA RCOR1 RBM25 TCF12 NFXL1 ARNT MEF2B SMARCA5 EBF1 IKZF1 BCAS1 CYP24A1 MIR4756 RF00951-092
GH20J054059 Promoter 0.8 EPDnew 0.4 +9.4 9445 0.1 RBM25 POLR2A ZNF282 CREB3L1 NFXL1 POLR2H ZBTB33 PAX5 NCOA1 SP1 BCAS1 PFDN4 MIR4756 RF00951-092
GH20J054044 Enhancer 1 Ensembl ENCODE 0.4 +24.5 24484 3.6 RELA MYC CTBP1 JUN HDAC3 BCL11A NCOR1 NEUROD1 CREB1 ZNF316 BCAS1 MIR4756 RF00951-092
GH20J054062 Enhancer 0.7 ENCODE 0.4 +5.5 5538 0.2 EP300 CTCF REST RAD21 SKI TRIM22 SMC3 PBX2 ZGPAT RB1 CYP24A1 BCAS1 MIR4756 RF00951-092
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4756 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4756 Gene

Genomic Locations for MIR4756 Gene
chr20:54,068,408-54,068,485
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr20:52,684,947-52,685,024
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR4756 Gene

Genes around MIR4756 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4756 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4756 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4756 Gene

Proteins for MIR4756 Gene

Post-translational modifications for MIR4756 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4756 Gene

Domains & Families for MIR4756 Gene

Gene Families for MIR4756 Gene

HGNC:
genes like me logo Genes that share domains with MIR4756: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4756 Gene

Function for MIR4756 Gene

Phenotypes From GWAS Catalog for MIR4756 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4756 Gene

Localization for MIR4756 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4756 Gene

Pathways & Interactions for MIR4756 Gene

PathCards logo

SuperPathways for MIR4756 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4756 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4756 Gene

Drugs & Compounds for MIR4756 Gene

No Compound Related Data Available

Transcripts for MIR4756 Gene

mRNA/cDNA for MIR4756 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
2 ENA transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4756 Gene

No ASD Table

Relevant External Links for MIR4756 Gene

GeneLoc Exon Structure for
MIR4756

Expression for MIR4756 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4756 Gene

genes like me logo Genes that share expression patterns with MIR4756: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4756 Gene

Orthologs for MIR4756 Gene

Evolution for MIR4756 Gene

ENSEMBL:
Gene Tree for MIR4756 (if available)
TreeFam:
Gene Tree for MIR4756 (if available)

No data available for Orthologs for MIR4756 Gene

Paralogs for MIR4756 Gene

No data available for Paralogs for MIR4756 Gene

Variants for MIR4756 Gene

Additional dbSNP identifiers (rs#s) for MIR4756 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4756 Gene

Variant ID Type Subtype PubMed ID
dgv1254e212 CNV loss 25503493
esv2758801 CNV loss 17122850
esv34060 CNV loss 18971310
nsv586224 CNV gain 21841781

Additional Variant Information for MIR4756 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4756

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4756 Gene

Disorders for MIR4756 Gene

Additional Disease Information for MIR4756

No disorders were found for MIR4756 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4756 Gene

Publications for MIR4756 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4756 Gene

Sources for MIR4756 Gene