microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4753 Gene

Subcategory (RNA class) for MIR4753 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4753 Gene

  • MicroRNA 4753 2 3 5
  • Hsa-Mir-4753 2 3
  • MIR4753 2 5
  • MIMAT0019890 50
  • MIMAT0019891 50
  • MI0017392 50
  • Mir-4753 3

External Ids for MIR4753 Gene

Previous GeneCards Identifiers for MIR4753 Gene

  • GC01U903288
  • GC01M235357

Summaries for MIR4753 Gene

Entrez Gene Summary for MIR4753 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4753 Gene

MIR4753 (MicroRNA 4753) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4753 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4753 Gene

Genomics for MIR4753 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4753 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J235206 Enhancer 1 Ensembl ENCODE 0.4 -16.7 -16685 2.4 ZNF512 IKZF1 ZNF7 MTA2 ZNF24 MTA1 ZNF239 HDAC1 RUNX3 DNMT1 ARID4B RPS21P1 B3GALNT2 SNORA14B TOMM20 GGPS1 IRF2BP2 MIR4753 RBM34 RPL23AP23
GH01J235199 Enhancer 0.6 Ensembl ENCODE 0.4 -9.6 -9585 1.4 CTCF TEAD4 PRDM1 ETS1 RAD21 ZNF654 SNORA14B TOMM20 ARID4B MIR4753 RBM34 RPL23AP23 GGPS1
GH01J235253 Enhancer 1 Ensembl ENCODE 0.2 -63.9 -63865 1.6 CEBPG CTCF IKZF1 JUND FOXA1 PRDM1 ZNF143 REST RAD21 IKZF2 GGPS1 ARID4B RPL23AP23 MIR4753 RBM34
GH01J235270 Promoter/Enhancer 1 Ensembl ENCODE 0.2 -80.8 -80759 1 ZNF629 PRDM1 ZNF600 ZNF561 ZNF10 TSHZ1 ZBTB17 ZNF184 IRF2 ZNF335 GGPS1 ARID4B RPL23AP23 MIR4753 RBM34
GH01J235244 Enhancer 0.7 Ensembl 0.2 -55.9 -55885 2.4 CEBPG PRDM1 PKNOX1 ATF7 RUNX3 CTBP1 TSHZ1 FOSL1 CUX1 GATA3 GGPS1 B3GALNT2 ARID4B RPL23AP23 MIR4753 RBM34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4753 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4753 Gene

Genomic Locations for MIR4753 Gene
chr1:235,190,034-235,190,116
(GRCh38/hg38)
Size:
83 bases
Orientation:
Minus strand
chr1:235,353,349-235,353,431
(GRCh37/hg19)
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR4753 Gene

Genes around MIR4753 on UCSC Golden Path with GeneCards custom track
MIR4753 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4753 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4753 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4753 Gene

Proteins for MIR4753 Gene

Post-translational modifications for MIR4753 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4753 Gene

Domains & Families for MIR4753 Gene

Gene Families for MIR4753 Gene

HGNC:
genes like me logo Genes that share domains with MIR4753: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4753 Gene

Function for MIR4753 Gene

Phenotypes From GWAS Catalog for MIR4753 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4753 Gene

Localization for MIR4753 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4753 Gene

Pathways & Interactions for MIR4753 Gene

PathCards logo

SuperPathways for MIR4753 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4753 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4753 Gene

Drugs & Compounds for MIR4753 Gene

No Compound Related Data Available

Transcripts for MIR4753 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4753 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DF35_9606 precursor_RNA 83 5

HGNC: 41527,

RefSeq: NR_039908,

Ensembl: ENST00000585119 (view in UCSC) ,

miRBase: MI0017392,

ENA: LM611409.1:1..83:precursor_RNA,

URS00003AA845_9606 miRNA 22 3

RefSeq: NR_039908,

miRBase: MIMAT0019891,

ENA: FR773050.1:1..22:ncRNA, LM611409.1:56..77:ncRNA,

URS00004B338E_9606 miRNA 22 3

RefSeq: NR_039908,

miRBase: MIMAT0019890,

ENA: FR773051.1:1..22:ncRNA, LM382578.1:1..22:ncRNA, LM611409.1:10..31:ncRNA,

MIR4753 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4753 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4753 Gene

No ASD Table

Relevant External Links for MIR4753 Gene

GeneLoc Exon Structure for
MIR4753

Expression for MIR4753 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4753 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4753

genes like me logo Genes that share expression patterns with MIR4753: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4753 Gene

Orthologs for MIR4753 Gene

Evolution for MIR4753 Gene

ENSEMBL:
Gene Tree for MIR4753 (if available)
TreeFam:
Gene Tree for MIR4753 (if available)

No data available for Orthologs for MIR4753 Gene

Paralogs for MIR4753 Gene

No data available for Paralogs for MIR4753 Gene

Variants for MIR4753 Gene

Additional dbSNP identifiers (rs#s) for MIR4753 Gene

Additional Variant Information for MIR4753 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4753

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4753 Gene

Disorders for MIR4753 Gene

Additional Disease Information for MIR4753

No disorders were found for MIR4753 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4753 Gene

Publications for MIR4753 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4753 Gene

Sources for MIR4753 Gene