microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4750 Gene

Subcategory (RNA class) for MIR4750 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4750 Gene

  • MicroRNA 4750 2 3 5
  • Hsa-Mir-4750 2 3
  • MIR4750 2 5
  • MIMAT0022979 50
  • MIMAT0019887 50
  • MI0017389 50
  • Mir-4750 3

External Ids for MIR4750 Gene

Previous GeneCards Identifiers for MIR4750 Gene

  • GC19U901543
  • GC19P050393

Summaries for MIR4750 Gene

Entrez Gene Summary for MIR4750 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4750 Gene

MIR4750 (MicroRNA 4750) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TBC/RABGAPs and Vesicle-mediated transport.

Additional gene information for MIR4750 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4750 Gene

Genomics for MIR4750 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4750 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049887 Enhancer 0.4 Ensembl 600.7 -0.8 -774 0.4 POLR2A RBFOX2 KLF8 ZBTB33 MIR4750 AKT1S1 TBC1D17 lnc-NUP62-1 ATF5
GH19J049889 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 0.7 +2.3 2338 1.8 RNF2 CTCF ZBTB33 HNRNPL LEF1 IKZF1 KDM1A ZNF692 BACH1 JUND PRR12 PRMT1 SNRNP70 ENSG00000268047 NUP62 CLEC11A RPS9P4 PTOV1-AS2 PNKP MIR4750
GH19J049894 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 +8.5 8475 4 SP1 TFE3 LEF1 BACH1 JUND LARP7 STAT3 PRDM1 ZNF143 RELA IL4I1 NUP62 POLD1 AKT1S1 MED25 NR1H2 PNKP PTOV1-AS2 ATF5 TBC1D17
GH19J049879 Enhancer 0.8 ENCODE dbSUPER 0.4 -8.7 -8696 0.2 ZNF143 GABPA SP2 SIX5 ZBTB11 SPI1 CREM ZNF513 THAP11 ZBTB40 AKT1S1 PNKP lnc-PNKP-8 TBC1D17 MIR4750 ATF5
GH19J049884 Enhancer 0.5 Ensembl 0.7 -3.4 -3374 0.4 NFE2 ZNF316 MAFF MAFG MAFK EMSY MIR4750 AKT1S1 TBC1D17 ATF5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4750 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4750 Gene

Genomic Locations for MIR4750 Gene
chr19:49,888,175-49,888,230
(GRCh38/hg38)
Size:
56 bases
Orientation:
Plus strand
chr19:50,391,428-50,391,494
(GRCh37/hg19)
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR4750 Gene

Genes around MIR4750 on UCSC Golden Path with GeneCards custom track
MIR4750 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4750 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4750 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4750 Gene

Proteins for MIR4750 Gene

Post-translational modifications for MIR4750 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4750 Gene

Domains & Families for MIR4750 Gene

Gene Families for MIR4750 Gene

HGNC:
genes like me logo Genes that share domains with MIR4750: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4750 Gene

Function for MIR4750 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4750 Gene

Localization for MIR4750 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4750 Gene

Pathways & Interactions for MIR4750 Gene

PathCards logo

SuperPathways for MIR4750 Gene

genes like me logo Genes that share pathways with MIR4750: view

Pathways by source for MIR4750 Gene

3 Reactome pathways for MIR4750 Gene

Gene Ontology (GO) - Biological Process for MIR4750 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4750 Gene

Drugs & Compounds for MIR4750 Gene

No Compound Related Data Available

Transcripts for MIR4750 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4750 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DADC_9606 precursor_RNA 56 5

HGNC: 41765,

RefSeq: NR_039905,

Ensembl: ENST00000584564 (view in UCSC) ,

miRBase: MI0017389,

ENA: LM611408.1:1..56:precursor_RNA,

URS0000210075_9606 miRNA 22 3

RefSeq: NR_039905,

miRBase: MIMAT0019887,

ENA: FR773047.1:1..22:ncRNA, LM382577.1:1..22:ncRNA, LM611408.1:3..24:ncRNA,

URS000075EC59_9606 miRNA 22 3

RefSeq: NR_039905,

miRBase: MIMAT0022979,

ENA: LM611408.1:35..56:ncRNA,

MIR4750 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4750 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4750 Gene

No ASD Table

Relevant External Links for MIR4750 Gene

GeneLoc Exon Structure for
MIR4750

Expression for MIR4750 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4750 Gene

genes like me logo Genes that share expression patterns with MIR4750: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4750 Gene

Orthologs for MIR4750 Gene

Evolution for MIR4750 Gene

ENSEMBL:
Gene Tree for MIR4750 (if available)
TreeFam:
Gene Tree for MIR4750 (if available)

No data available for Orthologs for MIR4750 Gene

Paralogs for MIR4750 Gene

No data available for Paralogs for MIR4750 Gene

Variants for MIR4750 Gene

Additional dbSNP identifiers (rs#s) for MIR4750 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4750 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
esv3644628 CNV gain 21293372
esv3644630 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2519 CNV deletion 18451855
nsv524068 CNV loss 19592680
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Additional Variant Information for MIR4750 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4750

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4750 Gene

Disorders for MIR4750 Gene

Additional Disease Information for MIR4750

No disorders were found for MIR4750 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4750 Gene

Publications for MIR4750 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4750 Gene

Sources for MIR4750 Gene