Aliases for MIR4750 Gene
Subcategory (RNA class) for MIR4750 Gene
miRNA
Quality Score for this RNA gene is
13
External Ids for MIR4750 Gene
- HGNC: 41765
- Entrez Gene: 100616314
- Ensembl: ENSG00000284394
- miRBase: hsa-mir-4750
Previous GeneCards Identifiers for MIR4750 Gene
- GC19U901543
- GC19P050393
Summaries for MIR4750 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4750 Gene
MIR4750 (MicroRNA 4750) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Vesicle-mediated transport and TBC/RABGAPs.
Additional gene information for MIR4750 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4750 Gene
Genomics for MIR4750 Gene
GeneHancer (GH) Regulatory Elements for MIR4750 Gene
Promoters and enhancers for MIR4750 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J049889 | Enhancer | 1.2 | ENCODE dbSUPER | 600.7 | +2.0 | 1994 | 1.1 | SP1 ZFX NKRF MLLT1 GTF2F1 ZNF687 CTCF MYC NCOA6 SP7 | MIR4750 PRR12 PRMT1 SNRNP70 ENSG00000268047 NUP62 CLEC11A ENSG00000243829 PTOV1-AS2 PIR32099 | |
| GH19J049887 | Enhancer | 0.4 | Ensembl | 600.7 | -0.7 | -674 | 0.6 | ZBTB33 KLF8 POLR2A | MIR4750 AKT1S1 TBC1D17 | |
| GH19J049894 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +8.5 | 8475 | 4 | SP1 ZNF148 NKRF MLLT1 ZNF687 MCM2 MAFK TFE3 SP7 RELA | IL4I1 NUP62 POLD1 AKT1S1 MED25 NR1H2 PNKP PTOV1-AS2 ATF5 TBC1D17 | |
| GH19J049890 | Enhancer | 0.8 | ENCODE dbSUPER | 0.7 | +2.7 | 2684 | 0.2 | ZNF639 ZNF740 FOSL1 ZFP69B ZNF335 VEZF1 SP3 KLF1 | PTOV1-AS2 MIR4750 PIR32099 IL4I1 | |
| GH19J049891 | Enhancer | 0.7 | ENCODE dbSUPER | 0.7 | +3.0 | 2951 | 0.1 | ZNF740 ZNF692 ZFP69B VEZF1 | MIR4750 PIR32099 IL4I1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR4750 on UCSC Golden Path with GeneCards custom track
Genomic Locations for MIR4750 Gene
Genomic Locations for MIR4750 Gene
- chr19:49,888,175-49,888,230
- (GRCh38/hg38)
- Size:
- 56 bases
- Orientation:
- Plus strand
- chr19:50,391,428-50,391,494
- (GRCh37/hg19)
- Size:
- 67 bases
- Orientation:
- Plus strand
Genomic View for MIR4750 Gene
Genes around MIR4750 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
MIR4750 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR4750 Gene
Proteins for MIR4750 Gene
Post-translational modifications for MIR4750 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4750
- Origene Custom Protein Services for MIR4750
No data available for DME Specific Peptides for MIR4750 Gene
Domains & Families for MIR4750 Gene
Gene Families for MIR4750 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4750 Gene
Function for MIR4750 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR4750
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR4750 - Now 50% OFF >
- * MIR4750 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR4750 CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for MIR4750
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR4750 - Now 50% OFF >
- * MIR4750 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR4750 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4750 Gene
Localization for MIR4750 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4750 Gene
Pathways & Interactions for MIR4750 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | TBC/RABGAPs | ||
Pathways by source for MIR4750 Gene
3 Reactome pathways for MIR4750 Gene
Interacting Proteins for MIR4750 Gene
No data available for SIGNOR curated interactions for MIR4750 Gene
Transcripts for MIR4750 Gene
mRNA/cDNA for MIR4750 Gene
- (1) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000584564 56 bps (ENST00000584564.1)
- (3) RNA Central transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR4750 - Now 50% OFF >
- * MIR4750 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR4750 CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for MIR4750
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR4750 - Now 50% OFF >
- * MIR4750 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MIR4750 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MIR4750 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR4750 Gene:
MIR4750Primer Products
-
OriGene qPCR primer pairs for MIR4750
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4750 Gene
Orthologs for MIR4750 Gene
No data available for Orthologs for MIR4750 Gene
Paralogs for MIR4750 Gene
No data available for Paralogs for MIR4750 Gene
Variants for MIR4750 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000555472 | -- | 49,888,326(+) | C/T | downstream_transcript_variant | |
| rs1001515127 | -- | 49,887,209(+) | G/T | upstream_transcript_variant | |
| rs1002485292 | -- | 49,886,473(+) | C/T | upstream_transcript_variant | |
| rs1002516331 | -- | 49,886,196(+) | C/T | upstream_transcript_variant | |
| rs1003458505 | -- | 49,887,257(+) | T/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv53n68 | CNV | loss | 17160897 |
| dgv54n68 | CNV | loss | 17160897 |
| esv3644628 | CNV | gain | 21293372 |
| esv3644630 | CNV | gain | 21293372 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv2519 | CNV | deletion | 18451855 |
| nsv524068 | CNV | loss | 19592680 |
| nsv953600 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Additional Variant Information for MIR4750 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4750
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4750 Gene
Disorders for MIR4750 Gene
Additional Disease Information for MIR4750
No disorders were found for MIR4750 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4750 Gene
Publications for MIR4750 Gene
- miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
- Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
ExternalLinks
Products for MIR4750 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4750
- Origene Custom Protein Services for MIR4750
- Browse OriGene Inhibitory RNA Products For MIR4750
- OriGene qPCR primer pairs for MIR4750
- Browse CRISPR knockouts for MIR4750
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR4750
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR4750
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR4750
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR4750
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR4750
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR4750
Sources for MIR4750 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind