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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4750 (MicroRNA 4750) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TBC/RABGAPs and Vesicle-mediated transport.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J049887 | Enhancer | 0.4 | Ensembl | 600.7 | -0.8 | -774 | 0.4 | POLR2A RBFOX2 KLF8 ZBTB33 | MIR4750 AKT1S1 TBC1D17 lnc-NUP62-1 ATF5 | |
GH19J049889 | Promoter/Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 0.7 | +2.3 | 2338 | 1.8 | RNF2 CTCF ZBTB33 HNRNPL LEF1 IKZF1 KDM1A ZNF692 BACH1 JUND | PRR12 PRMT1 SNRNP70 ENSG00000268047 NUP62 CLEC11A RPS9P4 PTOV1-AS2 PNKP MIR4750 | |
GH19J049894 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +8.5 | 8475 | 4 | SP1 TFE3 LEF1 BACH1 JUND LARP7 STAT3 PRDM1 ZNF143 RELA | IL4I1 NUP62 POLD1 AKT1S1 MED25 NR1H2 PNKP PTOV1-AS2 ATF5 TBC1D17 | |
GH19J049879 | Enhancer | 0.8 | ENCODE dbSUPER | 0.4 | -8.7 | -8696 | 0.2 | ZNF143 GABPA SP2 SIX5 ZBTB11 SPI1 CREM ZNF513 THAP11 ZBTB40 | AKT1S1 PNKP lnc-PNKP-8 TBC1D17 MIR4750 ATF5 | |
GH19J049884 | Enhancer | 0.5 | Ensembl | 0.7 | -3.4 | -3374 | 0.4 | NFE2 ZNF316 MAFF MAFG MAFK EMSY | MIR4750 AKT1S1 TBC1D17 ATF5 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | TBC/RABGAPs |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075DADC_9606 | precursor_RNA | 56 | 5 |
HGNC: 41765, RefSeq: NR_039905, Ensembl: ENST00000584564 (view in UCSC) , miRBase: MI0017389, |
URS0000210075_9606 | miRNA | 22 | 3 |
RefSeq: NR_039905, miRBase: MIMAT0019887, ENA: FR773047.1:1..22:ncRNA, LM382577.1:1..22:ncRNA, LM611408.1:3..24:ncRNA, |
URS000075EC59_9606 | miRNA | 22 | 3 |
RefSeq: NR_039905, miRBase: MIMAT0022979, ENA: LM611408.1:35..56:ncRNA, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv53n68 | CNV | loss | 17160897 |
dgv54n68 | CNV | loss | 17160897 |
esv3644628 | CNV | gain | 21293372 |
esv3644630 | CNV | gain | 21293372 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv2519 | CNV | deletion | 18451855 |
nsv524068 | CNV | loss | 19592680 |
nsv953600 | CNV | deletion | 24416366 |
nsv9739 | CNV | gain+loss | 18304495 |
No disorders were found for MIR4750 Gene.