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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4749 (MicroRNA 4749) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J049855 | Enhancer | 0.8 | Ensembl ENCODE | 600.7 | +1.2 | 1173 | 1.1 | PRDM10 POLR2A ZNF600 KLF9 KLF7 ZNF10 ZKSCAN8 KDM1A ZKSCAN1 PTBP1 | ENSG00000268047 MIR4749 PNKP RRAS PTOV1-AS2 PTOV1 TBC1D17 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903561 | extracellular vesicle | HDA | 28798470 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075D57A_9606 | precursor_RNA | 61 | 5 |
HGNC: 41760, RefSeq: NR_039904, Ensembl: ENST00000578197 (view in UCSC) , miRBase: MI0017388, |
URS00000CDD4F_9606 | miRNA | 22 | 3 |
RefSeq: NR_039904, miRBase: MIMAT0019885, ENA: FR773046.1:1..22:ncRNA, LM382576.1:1..22:ncRNA, LM611407.1:3..24:ncRNA, |
URS0000077DDE_9606 | miRNA | 20 | 3 |
RefSeq: NR_039904, miRBase: MIMAT0019886, |
No disorders were found for MIR4749 Gene.