microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4749 Gene

Subcategory (RNA class) for MIR4749 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4749 Gene

  • MicroRNA 4749 2 3 5
  • Hsa-Mir-4749 2 3
  • MIR4749 2 5
  • MIMAT0019886 50
  • MIMAT0019885 50
  • MI0017388 50
  • Mir-4749 3

External Ids for MIR4749 Gene

Previous GeneCards Identifiers for MIR4749 Gene

  • GC19U901546
  • GC19P050361

Summaries for MIR4749 Gene

Entrez Gene Summary for MIR4749 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4749 Gene

MIR4749 (MicroRNA 4749) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4749 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4749 Gene

Genomics for MIR4749 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4749 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049855 Enhancer 0.8 Ensembl ENCODE 600.7 +1.2 1173 1.1 PRDM10 POLR2A ZNF600 KLF9 KLF7 ZNF10 ZKSCAN8 KDM1A ZKSCAN1 PTBP1 ENSG00000268047 MIR4749 PNKP RRAS PTOV1-AS2 PTOV1 TBC1D17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4749 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4749 Gene

Genomic Locations for MIR4749 Gene
chr19:49,854,591-49,854,651
(GRCh38/hg38)
Size:
61 bases
Orientation:
Plus strand
chr19:50,357,841-50,357,917
(GRCh37/hg19)
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR4749 Gene

Genes around MIR4749 on UCSC Golden Path with GeneCards custom track
MIR4749 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4749 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4749 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4749 Gene

Proteins for MIR4749 Gene

Post-translational modifications for MIR4749 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4749 Gene

Domains & Families for MIR4749 Gene

Gene Families for MIR4749 Gene

HGNC:
genes like me logo Genes that share domains with MIR4749: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4749 Gene

Function for MIR4749 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4749 Gene

Localization for MIR4749 Gene

Gene Ontology (GO) - Cellular Components for MIR4749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR4749: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4749 Gene

Pathways & Interactions for MIR4749 Gene

PathCards logo

SuperPathways for MIR4749 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4749 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4749 Gene

Drugs & Compounds for MIR4749 Gene

No Compound Related Data Available

Transcripts for MIR4749 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4749 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D57A_9606 precursor_RNA 61 5

HGNC: 41760,

RefSeq: NR_039904,

Ensembl: ENST00000578197 (view in UCSC) ,

miRBase: MI0017388,

ENA: LM611407.1:1..61:precursor_RNA,

URS00000CDD4F_9606 miRNA 22 3

RefSeq: NR_039904,

miRBase: MIMAT0019885,

ENA: FR773046.1:1..22:ncRNA, LM382576.1:1..22:ncRNA, LM611407.1:3..24:ncRNA,

URS0000077DDE_9606 miRNA 20 3

RefSeq: NR_039904,

miRBase: MIMAT0019886,

ENA: FR773045.1:1..20:ncRNA, LM611407.1:42..61:ncRNA,

MIR4749 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4749 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4749 Gene

No ASD Table

Relevant External Links for MIR4749 Gene

GeneLoc Exon Structure for
MIR4749

Expression for MIR4749 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4749 Gene

Orthologs for MIR4749 Gene

Evolution for MIR4749 Gene

ENSEMBL:
Gene Tree for MIR4749 (if available)
TreeFam:
Gene Tree for MIR4749 (if available)

No data available for Orthologs for MIR4749 Gene

Paralogs for MIR4749 Gene

No data available for Paralogs for MIR4749 Gene

Variants for MIR4749 Gene

Additional dbSNP identifiers (rs#s) for MIR4749 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4749 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
nsv1140251 OTHER inversion 24896259
nsv470150 CNV gain 18288195
nsv524068 CNV loss 19592680
nsv524534 CNV loss 19592680
nsv526372 CNV loss 19592680
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Additional Variant Information for MIR4749 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4749

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4749 Gene

Disorders for MIR4749 Gene

Additional Disease Information for MIR4749

No disorders were found for MIR4749 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4749 Gene

Publications for MIR4749 Gene

  1. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4749 Gene

Sources for MIR4749 Gene