microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4744 Gene

Data sources for MIR4744 Gene:

RNA type for MIR4744 Gene

miRNA

Aliases for MIR4744 Gene

External Ids for MIR4744 Gene

Previous GeneCards Identifiers for MIR4744 Gene

  • GC18U900670
  • GC18M046581

Summaries for MIR4744 Gene

Entrez Gene Summary for MIR4744 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4744 Gene

MIR4744 (MicroRNA 4744) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4744 Gene

Genomics for MIR4744 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4744 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J049047 Enhancer 0.6 Ensembl ENCODE dbSUPER 250.7 +1.2 1167 2.8 CEBPB MIR4744 SMAD7 lnc-DYM-1 LOC100129878 DYM
GH18J049050 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -2.4 -2390 3.9 JUND GABPA MAX POLR2A REST GATA2 CHD1 CHD2 PRDM10 EP300 SMAD7 DYM MIR4744 HSALNG0121469
GH18J049044 Enhancer 1 Ensembl ENCODE dbSUPER 0.7 +4.1 4104 1.9 ZIC2 ZNF148 KLF9 GLIS1 ZSCAN4 ZSCAN26 EGR2 ZNF791 ZNF473 ZNF776 RPL17 SMAD7 MIR4744 lnc-DYM-1 LOC100129878 DYM
GH18J049054 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 0.4 -6.2 -6160 2.6 MYC ZNF592 BCL11A BHLHE40 MNT IRF4 RAD21 SPI1 ETV1 MAX DYM SMAD7 MIR4744 HSALNG0121469
GH18J049061 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -12.3 -12333 2.2 NCOR1 TAL1 PRDM10 HDAC2 TCF12 TEAD4 ZNF398 L3MBTL2 MEIS2 GATA2 DYM HSALNG0121469 MIR4744 SMAD7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4744 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4744 Gene

Latest Assembly
chr18:49,049,687-49,049,768
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand

Previous Assembly
chr18:46,576,057-46,576,138
(GRCh37/hg19 by Entrez Gene)
Size:
82 bases
Orientation:
Minus strand

chr18:46,576,057-46,576,138
(GRCh37/hg19 by Ensembl)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR4744 Gene

Genes around MIR4744 on UCSC Golden Path with GeneCards custom track
MIR4744 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4744 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4744 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4744 Gene

Proteins for MIR4744 Gene

Post-translational modifications for MIR4744 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4744 Gene

Domains & Families for MIR4744 Gene

Gene Families for MIR4744 Gene

HGNC:
genes like me logo Genes that share domains with MIR4744: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4744 Gene

Function for MIR4744 Gene

Phenotypes From GWAS Catalog for MIR4744 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4744 Gene

Localization for MIR4744 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4744 Gene

Pathways & Interactions for MIR4744 Gene

PathCards logo

SuperPathways for MIR4744 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4744 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4744 Gene

Drugs & Compounds for MIR4744 Gene

No Compound Related Data Available

Transcripts for MIR4744 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4744 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075DDA1_9606 precursor_RNA 82 3

RefSeq: NR_039898,

Ensembl: ENST00000581563 (view in UCSC) ,

miRBase: MI0017382,

URS00004B9C33_9606 miRNA 23 3

RefSeq: NR_039898,

miRBase: MIMAT0019875,

ENA: FR773037.1:1..23:ncRNA,

MIR4744 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4744 Gene

No ASD Table

Relevant External Links for MIR4744 Gene

GeneLoc Exon Structure for
MIR4744

No data available for mRNA/cDNA for MIR4744 Gene

Expression for MIR4744 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4744 Gene

genes like me logo Genes that share expression patterns with MIR4744: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4744 Gene

Orthologs for MIR4744 Gene

Evolution for MIR4744 Gene

ENSEMBL:
Gene Tree for MIR4744 (if available)
TreeFam:
Gene Tree for MIR4744 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4744

No data available for Orthologs for MIR4744 Gene

Paralogs for MIR4744 Gene

No data available for Paralogs for MIR4744 Gene

Variants for MIR4744 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4744 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4744 Gene

Variant ID Type Subtype PubMed ID
nsv1055175 CNV gain 25217958
nsv833646 CNV gain 17160897

Additional Variant Information for MIR4744 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4744
Leiden Open Variation Database (LOVD)
MIR4744

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4744 Gene

Disorders for MIR4744 Gene

Additional Disease Information for MIR4744

No disorders were found for MIR4744 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4744 Gene

Publications for MIR4744 Gene

  1. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4744 Gene

Sources for MIR4744 Gene