MIR4739 Gene (RNA Gene)

MicroRNA 4739

GC17M079707
GIFtS:
12
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4739 Gene

Subcategory (RNA class) for MIR4739 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR4739 Gene

  • MicroRNA 4739 2 3 5
  • Hsa-Mir-4739 3
  • MIMAT0019868 53
  • MI0017377 53
  • Mir-4739 3
  • MIR4739 2

External Ids for MIR4739 Gene

Previous GeneCards Identifiers for MIR4739 Gene

  • GC17U901652
  • GC17M077683

Summaries for MIR4739 Gene

Entrez Gene Summary for MIR4739 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4739 Gene

MIR4739 (MicroRNA 4739) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4739 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4739 Gene

Genomics for MIR4739 Gene

GeneHancer (GH) Regulatory Elements for MIR4739 Gene

Promoters and enhancers for MIR4739 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J079708 Promoter/Enhancer 1 Ensembl CraniofacialAtlas 750.6 -1.0 -1048 1 CTCF RAD21 KLF14 GLIS2 ZIC2 REST TCF7L2 LEF1 PATZ1 TRIM22 LINC02078 MIR4739 piR-34843-002
GH17J079706 Enhancer 0.4 CraniofacialAtlas 750.6 +0.1 57 0.4 POLR2A WT1 KLF17 KLF1 LINC02078 MIR4739 lnc-CBX8-6
GH17J079702 Enhancer 0.7 Ensembl ENCODE 0.6 +4.8 4782 0.7 ZEB2 CTCF BHLHE40 GLIS1 NFXL1 KLF1 MIR4739 lnc-CBX8-6
GH17J079694 Enhancer 0.8 Ensembl CraniofacialAtlas 0.4 +10.9 10948 2.2 RELA PRDM1 IKZF1 GLIS2 IKZF2 ZNF148 PATZ1 MNT ZNF207 DPF2 MIR4739 lnc-CBX8-6
GH17J079699 Enhancer 0.6 Ensembl 0.4 +6.9 6948 1.4 ZBTB40 PRDM1 KLF14 GLIS2 ZBTB8A SP2 GABPA ZBTB11 ZFHX2 GLIS1 MIR4739 lnc-CBX8-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4739 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4739 Gene

Genomic Locations for MIR4739 Gene
chr17:79,707,176-79,707,249
(GRCh38/hg38)
Size:
74 bases
Orientation:
Minus strand
chr17:77,680,985-77,681,058
(GRCh37/hg19)
Size:
74 bases
Orientation:
Minus strand

Genomic View for MIR4739 Gene

Genes around MIR4739 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4739 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4739 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR4739 Gene

Proteins for MIR4739 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR4739 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4739 Gene

Domains & Families for MIR4739 Gene

Gene Families for MIR4739 Gene

HGNC:
genes like me logo Genes that share domains with MIR4739: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4739 Gene

Function for MIR4739 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR4739 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4739 Gene

Localization for MIR4739 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4739 Gene

Pathways & Interactions for MIR4739 Gene

PathCards logo

SuperPathways for MIR4739 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4739 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4739 Gene

Drugs & Compounds for MIR4739 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR4739 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR4739 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(4) ENA transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4739 Gene

No ASD Table

Relevant External Links for MIR4739 Gene

GeneLoc Exon Structure for
MIR4739
ECgene alternative splicing isoforms for
MIR4739

Expression for MIR4739 Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR4739 Gene:

MIR4739
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4739 Gene

Orthologs for MIR4739 Gene

Evolution for MIR4739 Gene

ENSEMBL:
Gene Tree for MIR4739 (if available)
TreeFam:
Gene Tree for MIR4739 (if available)

No data available for Orthologs for MIR4739 Gene

Paralogs for MIR4739 Gene

No data available for Paralogs for MIR4739 Gene

Variants for MIR4739 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR4739 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs111311094 -- 79,708,331(-) G/C upstream_transcript_variant
rs111599301 -- 79,709,204(-) C/A upstream_transcript_variant
rs111756458 -- 79,709,186(-) T/C upstream_transcript_variant
rs111789255 -- 79,709,218(-) G/C upstream_transcript_variant
rs112037869 -- 79,709,193(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4739 Gene

Variant ID Type Subtype PubMed ID
dgv590e214 CNV loss 21293372
esv28226 CNV gain+loss 19812545
nsv952381 CNV deletion 24416366
nsv9594 CNV gain 18304495

Additional Variant Information for MIR4739 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4739

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4739 Gene

Disorders for MIR4739 Gene

Additional Disease Information for MIR4739

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR4739 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4739 Gene

Publications for MIR4739 Gene

  1. miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7. (PMID: 30850350) Wang M … Ye H (EBioMedicine 2019) 3 56
  2. Circulating MicroRNA-4739 May Be a Potential Biomarker of Critical Limb Ischemia in Patients with Diabetes. (PMID: 30539011) Li JY … Deng AP (BioMed research international 2018) 3 56
  3. MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3. (PMID: 28340487) Elsafadi M … Mahmood A (Stem cell research 2017) 3 56
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 56
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 56

ExternalLinks

View latest publications for MIR4739 gene in Mastermind

Products for MIR4739 Gene

Sources for MIR4739 Gene