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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4738 (MicroRNA 4738) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and Mitotic Prophase.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J075776 | Promoter/Enhancer | 2.8 | UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +2.7 | 2717 | 11.6 | RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ARID3A TEAD4 | UNK SRSF2 NUP85 NT5C ENSG00000267342 TRIM65 ENSG00000266980 GGA3 ENSG00000267546 METTL23 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Mitotic Prophase |
.57
|
|
5 | Meiosis |
.73
|
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000299FE3_9606 | miRNA | 22 | 5 |
RefSeq: NR_039892, LncBase: hsa-miR-4738-3p, miRBase: MIMAT0019867, TarBase: hsa-miR-4738-3p, ENA: FR773028.1:1..22:ncRNA, |
URS000075993E_9606 | precursor_RNA | 87 | 4 |
HGNC: 41679, RefSeq: NR_039892, Ensembl: ENST00000579134 (view in UCSC) , miRBase: MI0017376, |
URS00000CA292_9606 | miRNA | 22 | 3 |
RefSeq: NR_039892, miRBase: MIMAT0019866, ENA: FR773029.1:1..22:ncRNA, |
No disorders were found for MIR4738 Gene.