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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR4738 Gene
Data sources for MIR4738 Gene:
RNA type for MIR4738 Gene
miRNA
Aliases for MIR4738 Gene
External Ids for MIR4738 Gene
- HGNC: 41679
- NCBI Entrez Gene: 100616282
- Ensembl: ENSG00000283853
- miRBase: hsa-mir-4738
Previous GeneCards Identifiers for MIR4738 Gene
- GC17U901645
- GC17M073784
- GC17M075777
Summaries for MIR4738 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4738 Gene
MIR4738 (MicroRNA 4738) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4738 include Combat Disorder. Among its related pathways are Cellular Senescence (REACTOME) and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Additional gene information for MIR4738 Gene
- Alliance of Genome Resources
- Search for MIR4738 at DataMed
- Search for MIR4738 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4738 Gene
Genomics for MIR4738 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR4738 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J075775 | Promoter/Enhancer | 2.8 | UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +3.3 | 3297 | 12.7 | LARP7 BCLAF1 SP1 ZNF207 ZNF600 NCOR1 MYC IKZF1 SIX5 SSRP1 | UNK lnc-GALK1-2 SRSF2 NUP85 NT5C ENSG00000267342 TRIM65 ENSG00000266980 GGA3 ENSG00000267546 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR4738 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR4738 Gene
Latest Assembly
- chr17:75,784,521-75,784,607
- (GRCh38/hg38)
- Size:
- 87 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:73,780,602-73,780,688
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 87 bases
- Orientation:
- Minus strand
Genomic View for MIR4738 Gene
Genes around MIR4738 on UCSC Golden Path with GeneCards custom track
MIR4738 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
MIR4738 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR4738 Gene
Proteins for MIR4738 Gene
Post-translational modifications for MIR4738 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR4738 Gene
Domains & Families for MIR4738 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4738 Gene
Function for MIR4738 Gene
Phenotypes From GWAS Catalog for MIR4738 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4738 - Starting at $85 >
- * MIR4738 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4738 - Starting at $45 >
- * MIR4738 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4738 Gene
Localization for MIR4738 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4738 Gene
Pathways & Interactions for MIR4738 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
|
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Mitotic Prophase |
.57
|
|
| 5 | Meiosis |
.73
|
|
Pathways by source for MIR4738 Gene
1 BioSystems pathway for MIR4738 Gene
43 Reactome pathways for MIR4738 Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
No data available for Interacting Proteins and SIGNOR curated interactions for MIR4738 Gene
Transcripts for MIR4738 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4738 Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS0000299FE3_9606 | miRNA | 22 | 5 |
RefSeq: NR_039892, LncBase: hsa-miR-4738-3p, miRBase: MIMAT0019867, TarBase: hsa-miR-4738-3p, ENA: FR773028.1:1..22:ncRNA, |
| URS000075993E_9606 | precursor_RNA | 87 | 3 |
RefSeq: NR_039892, Ensembl: ENST00000579134 (view in UCSC) , miRBase: MI0017376, |
| URS00000CA292_9606 | miRNA | 22 | 3 |
RefSeq: NR_039892, miRBase: MIMAT0019866, ENA: FR773029.1:1..22:ncRNA, |
MIR4738 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4738 - Starting at $85 >
- * MIR4738 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4738 - Starting at $45 >
- * MIR4738 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR4738 Gene
- GeneLoc Exon Structure for
- MIR4738
No data available for mRNA/cDNA for MIR4738 Gene
Expression for MIR4738 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4738
Primer products for research
-
OriGene qPCR primer pairs for MIR4738
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4738 Gene
Orthologs for MIR4738 Gene
Evolution for MIR4738 Gene
- ENSEMBL:
- Gene Tree for MIR4738 (if available)
- TreeFam:
- Gene Tree for MIR4738 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR4738
No data available for Orthologs for MIR4738 Gene
Paralogs for MIR4738 Gene
No data available for Paralogs for MIR4738 Gene
Variants for MIR4738 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR4738 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4738 Gene
Disorders for MIR4738 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| combat disorder |
|
|
Search MIR4738 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR4738
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4738 Gene
Publications for MIR4738 Gene
- Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
ExternalLinks
Products for MIR4738 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4738
- Origene Custom Protein Services for MIR4738
- Browse OriGene Inhibitory RNA Products For MIR4738
- OriGene qPCR primer pairs for MIR4738
- Browse CRISPR knockouts for MIR4738
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR4738
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR4738
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR4738
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR4738
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR4738
Sources for MIR4738 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources