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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4737 (MicroRNA 4737) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J060037 | Enhancer | 0.9 | ENCODE | 0.4 | +5.8 | 5840 | 0.2 | GATAD2A CTCF TEAD4 ZNF629 TFE3 KDM1A JUND ZNF143 RXRB RAD21 | RPS6KB1 TUBD1 MIR4737 HSALNG0117814 HEATR6 RNFT1 | |
GH17J060025 | Promoter | 0.6 | Ensembl | 0.4 | +16.2 | 16205 | 3 | SMARCA5 DDX20 SMARCE1 | ENSG00000274378 HSALNG0117814 MIR4737 HEATR6 RNFT1 | |
GH17J060034 | Enhancer | 0.4 | Ensembl | 0.4 | +8.4 | 8402 | 1 | RAD21 CTCF ZNF654 | RPS6KB1 TUBD1 HSALNG0117814 MIR4737 HEATR6 RNFT1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075DACB_9606 | precursor_RNA | 81 | 4 |
HGNC: 41669, RefSeq: NR_039890, Ensembl: ENST00000583979 (view in UCSC) , miRBase: MI0017374, |
URS000057DFC6_9606 | miRNA | 20 | 3 |
RefSeq: NR_039890, miRBase: MIMAT0019863, ENA: FR773027.1:1..20:ncRNA, |
No disorders were found for MIR4737 Gene.