microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4733 Gene

Subcategory (RNA class) for MIR4733 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR4733 Gene

  • MicroRNA 4733 2 3 5
  • Hsa-MiR-4733-5p 168 179
  • Hsa-Mir-4733 3
  • MIMAT0019858 53
  • MIMAT0019857 53
  • MI0017370 53
  • MIR4733 2

External Ids for MIR4733 Gene

Previous GeneCards Identifiers for MIR4733 Gene

  • GC17U901634
  • GC17M029425

Summaries for MIR4733 Gene

Entrez Gene Summary for MIR4733 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4733 Gene

MIR4733 (MicroRNA 4733) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4733 include Neurofibromatosis, Familial Spinal and Neurofibromatosis-Noonan Syndrome.

Additional gene information for MIR4733 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4733 Gene

Genomics for MIR4733 Gene

GeneHancer (GH) Regulatory Elements for MIR4733 Gene

Promoters and enhancers for MIR4733 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J031093 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 -1.0 -976 3.2 ZBTB6 RBPJ POLR2A CREB1 ZNF362 ZNF701 ELF1 ZNF148 GTF2F1 ELF3 NF1 ENSG00000264107 LOC105371722 MIR4733 RNF135 ENSG00000264456 SH3GL1P2 SUZ12 UTP6 DPRXP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4733 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4733 Gene

Genomic Locations for MIR4733 Gene
chr17:31,094,350-31,094,425
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr17:29,421,368-29,421,443
(GRCh37/hg19)
Size:
76 bases
Orientation:
Minus strand

Genomic View for MIR4733 Gene

Genes around MIR4733 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4733 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4733 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4733 Gene

Proteins for MIR4733 Gene

Post-translational modifications for MIR4733 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4733 Gene

Domains & Families for MIR4733 Gene

Gene Families for MIR4733 Gene

HGNC:
genes like me logo Genes that share domains with MIR4733: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4733 Gene

Function for MIR4733 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4733 Gene

Localization for MIR4733 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4733 Gene

Pathways & Interactions for MIR4733 Gene

PathCards logo

SuperPathways for MIR4733 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4733 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4733 Gene

Drugs & Compounds for MIR4733 Gene

No Compound Related Data Available

Transcripts for MIR4733 Gene

mRNA/cDNA for MIR4733 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(3) miRBase transcripts :
(2) ENA transcripts :
(1) LncBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4733 Gene

No ASD Table

Relevant External Links for MIR4733 Gene

GeneLoc Exon Structure for
MIR4733
ECgene alternative splicing isoforms for
MIR4733

Expression for MIR4733 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4733 Gene:

MIR4733
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4733 Gene

Orthologs for MIR4733 Gene

Evolution for MIR4733 Gene

ENSEMBL:
Gene Tree for MIR4733 (if available)
TreeFam:
Gene Tree for MIR4733 (if available)

No data available for Orthologs for MIR4733 Gene

Paralogs for MIR4733 Gene

No data available for Paralogs for MIR4733 Gene

Variants for MIR4733 Gene

Sequence variations from dbSNP and Humsavar for MIR4733 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1057516197 likely-pathogenic, Neurofibromatosis, type 1 31,095,323(-) GG/G upstream_transcript_variant
rs1057520334 uncertain-significance, not provided, Neurofibromatosis, type 1 31,095,355(-) C/T upstream_transcript_variant
rs1060500252 pathogenic, Neurofibromatosis, type 1 31,095,310(-) A/G upstream_transcript_variant
rs1060500261 uncertain-significance, Neurofibromatosis, type 1 31,095,346(-) G/A upstream_transcript_variant
rs1060503895 likely-benign, Neurofibromatosis, type 1 31,095,376(-) G/C upstream_transcript_variant

Additional Variant Information for MIR4733 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4733

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4733 Gene

Disorders for MIR4733 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR4733 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4733

genes like me logo Genes that share disorders with MIR4733: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4733 Gene

Publications for MIR4733 Gene

  1. TAGLN expression is upregulated in NF1-associated malignant peripheral nerve sheath tumors by hypomethylation in its promoter and subpromoter regions. (PMID: 25109740) Park GH … Jeong SY (Oncology reports 2014) 3 56
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 56
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR4733 Gene

Sources for MIR4733 Gene