microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4728 Gene

Subcategory (RNA class) for MIR4728 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4728 Gene

  • MicroRNA 4728 2 3 5
  • Hsa-Mir-4728 2 3
  • MIR4728 2 5
  • MIMAT0019849 50
  • MIMAT0019850 50
  • MI0017365 50

External Ids for MIR4728 Gene

Previous GeneCards Identifiers for MIR4728 Gene

  • GC17U901661
  • GC17P037885

Summaries for MIR4728 Gene

Entrez Gene Summary for MIR4728 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4728 Gene

MIR4728 (MicroRNA 4728) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4728 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4728 Gene

Genomics for MIR4728 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4728 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J039728 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.7 +3.5 3515 2.4 CREB1 GATAD2A CTCF ZNF629 TFE3 LEF1 POLR2A ZNF692 RCOR2 BACH1 MIEN1 lnc-MIEN1-2 SNORD124 GSDMA ORMDL3 GSDMB MIR4728 PGAP3 ERBB2
GH17J039723 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.7 -2.8 -2837 0.7 ZBTB33 DDX20 MTA2 PATZ1 NR2C1 DPF2 HDAC1 KLF9 SP2 POLR2A PGAP3 MIR4728 MF281430-030 MIEN1 ERBB2
GH17J039719 Enhancer 0.3 Ensembl dbSUPER 0.4 -7.1 -7094 0.4 MF281430-030 MIR4728 MIEN1 PGAP3 ERBB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4728 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4728 Gene

Genomic Locations for MIR4728 Gene
chr17:39,726,495-39,726,561
(GRCh38/hg38)
Size:
67 bases
Orientation:
Plus strand
chr17:37,882,732-37,882,819
(GRCh37/hg19)
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR4728 Gene

Genes around MIR4728 on UCSC Golden Path with GeneCards custom track
MIR4728 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4728 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4728 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4728 Gene

Proteins for MIR4728 Gene

Post-translational modifications for MIR4728 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4728 Gene

Domains & Families for MIR4728 Gene

Gene Families for MIR4728 Gene

HGNC:
genes like me logo Genes that share domains with MIR4728: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4728 Gene

Function for MIR4728 Gene

Phenotypes From GWAS Catalog for MIR4728 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4728 Gene

Localization for MIR4728 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4728 Gene

Pathways & Interactions for MIR4728 Gene

PathCards logo

SuperPathways for MIR4728 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4728 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4728 Gene

Drugs & Compounds for MIR4728 Gene

No Compound Related Data Available

Transcripts for MIR4728 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4728 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075CDD2_9606 precursor_RNA 67 4

HGNC: 41632,

RefSeq: NR_039881,

Ensembl: ENST00000580969 (view in UCSC) ,

miRBase: MI0017365,

URS00001FF3CD_9606 miRNA 25 3

RefSeq: NR_039881,

miRBase: MIMAT0019850,

ENA: FR773013.1:1..25:ncRNA,

URS00003067E3_9606 miRNA 23 3

RefSeq: NR_039881,

miRBase: MIMAT0019849,

ENA: FR773014.1:1..23:ncRNA,

MIR4728 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4728 Gene

No ASD Table

Relevant External Links for MIR4728 Gene

GeneLoc Exon Structure for
MIR4728

No data available for mRNA/cDNA for MIR4728 Gene

Expression for MIR4728 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4728 Gene

genes like me logo Genes that share expression patterns with MIR4728: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4728 Gene

Orthologs for MIR4728 Gene

Evolution for MIR4728 Gene

ENSEMBL:
Gene Tree for MIR4728 (if available)
TreeFam:
Gene Tree for MIR4728 (if available)

No data available for Orthologs for MIR4728 Gene

Paralogs for MIR4728 Gene

No data available for Paralogs for MIR4728 Gene

Variants for MIR4728 Gene

Additional dbSNP identifiers (rs#s) for MIR4728 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4728 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV loss 17160897
nsv1056234 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv2048 CNV insertion 18451855

Additional Variant Information for MIR4728 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4728

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4728 Gene

Disorders for MIR4728 Gene

Additional Disease Information for MIR4728

No disorders were found for MIR4728 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4728 Gene

Publications for MIR4728 Gene

  1. Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy. (PMID: 29476008) Floros KV … Faber AC (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  2. miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling. (PMID: 28594651) Pekow J … Bissonnette M (Inflammatory bowel diseases 2017) 3
  3. HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5. (PMID: 27752128) Newie I … Rovira C (Scientific reports 2016) 3
  4. Significant impact of miRNA-target gene networks on genetics of human complex traits. (PMID: 26927695) Okada Y … Tanaka T (Scientific reports 2016) 3
  5. ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. (PMID: 25950472) Schmitt DC … Tan M (Cell death & disease 2015) 3

Products for MIR4728 Gene

Sources for MIR4728 Gene