MIR4721 Gene (RNA Gene)

MicroRNA 4721

GC16M028863
GIFtS:
12
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4721 Gene

Subcategory (RNA class) for MIR4721 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4721 Gene

  • MicroRNA 4721 2 3 5
  • Hsa-Mir-4721 2 3
  • MIR4721 2 5
  • MIMAT0019835 50
  • MI0017356 50

External Ids for MIR4721 Gene

Previous GeneCards Identifiers for MIR4721 Gene

  • GC16U901344
  • GC16M028857

Summaries for MIR4721 Gene

Entrez Gene Summary for MIR4721 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4721 Gene

MIR4721 (MicroRNA 4721) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4721 include Retinitis Pigmentosa 41 and Retinitis Pigmentosa 27. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

Additional gene information for MIR4721 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4721 Gene

Genomics for MIR4721 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR4721 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J028844 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.7 -2.3 -2254 3.1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 TFE3 SIX5 TUFM SH2B1 ATXN2L NFATC2IP ENSG00000260853 SPNS1 SMG1P2 NPIPB12 ENSG00000260367 ENSG00000198106
GH16J028839 Enhancer 0.6 Ensembl 0.7 +3.8 3807 1.2 POLR2A RBFOX2 NR2C1 ZNF600 NFE2 ZBTB17 MAFG ZNF395 SPI1 ZNF584 TUFM ENSG00000260570 MIR4721 ATXN2L
GH16J028837 Enhancer 0.5 Ensembl 0.4 +6.2 6206 0.4 IKZF1 POLR2A RBM22 SUPT5H SSRP1 PAF1 ZBTB12 POLR2B ENSG00000260570 MIR4721 TUFM ATXN2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4721 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4721 Gene

Genomic Locations for MIR4721 Gene
chr16:28,843,919-28,844,007
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand
chr16:28,855,240-28,855,328
(GRCh37/hg19)
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR4721 Gene

Genes around MIR4721 on UCSC Golden Path with GeneCards custom track
MIR4721 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4721 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4721 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR4721 Gene

Proteins for MIR4721 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR4721 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4721 Gene

Domains & Families for MIR4721 Gene

Gene Families for MIR4721 Gene

HGNC:
genes like me logo Genes that share domains with MIR4721: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4721 Gene

Function for MIR4721 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR4721 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4721 Gene

Localization for MIR4721 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4721 Gene

Pathways & Interactions for MIR4721 Gene

genes like me logo Genes that share pathways with MIR4721: view

Pathways by source for MIR4721 Gene

Gene Ontology (GO) - Biological Process for MIR4721 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4721 Gene

Drugs & Compounds for MIR4721 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR4721 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4721 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EF66_9606 precursor_RNA 89 4

HGNC: 41609,

RefSeq: NR_039872,

Ensembl: ENST00000577590 (view in UCSC) ,

miRBase: MI0017356,

URS000036D67C_9606 miRNA 22 3

RefSeq: NR_039872,

miRBase: MIMAT0019835,

ENA: FR773000.1:1..22:ncRNA,

MIR4721 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4721 Gene

No ASD Table

Relevant External Links for MIR4721 Gene

GeneLoc Exon Structure for
MIR4721

No data available for mRNA/cDNA for MIR4721 Gene

Expression for MIR4721 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4721 Gene

mRNA expression in normal human tissues for MIR4721 Gene
mRNA expression by GTEx for MIR4721 Gene
genes like me logo Genes that share expression patterns with MIR4721: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4721 Gene

Orthologs for MIR4721 Gene

Evolution for MIR4721 Gene

ENSEMBL:
Gene Tree for MIR4721 (if available)
TreeFam:
Gene Tree for MIR4721 (if available)

No data available for Orthologs for MIR4721 Gene

Paralogs for MIR4721 Gene

No data available for Paralogs for MIR4721 Gene

Variants for MIR4721 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR4721 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
741249 Likely Benign: not provided 28,843,941(-) A/C NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR4721 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4721 Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
dgv502e214 CNV loss 21293372
esv2758640 CNV gain+loss 17122850
esv3570454 CNV gain 25503493
esv3638348 CNV gain 21293372
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781

Additional Variant Information for MIR4721 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4721

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4721 Gene

Disorders for MIR4721 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR4721 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 41
  • rp41
retinitis pigmentosa 27
  • rp27
usher syndrome, type ig
  • ush1g
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4721

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR4721: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4721 Gene

Publications for MIR4721 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

ExternalLinks

View latest publications for MIR4721 gene in Mastermind

Products for MIR4721 Gene

Sources for MIR4721 Gene