microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4717 Gene

Data sources for MIR4717 Gene:

RNA type for MIR4717 Gene

miRNA

Aliases for MIR4717 Gene

External Ids for MIR4717 Gene

Previous GeneCards Identifiers for MIR4717 Gene

  • GC16U901350
  • GC16P002328
  • GC16P002277
  • GC16P002314
  • GC16P002335
  • GC16P002356
  • GC16P002395
  • GC16P002282
  • GC16P002446
  • GC16P004443

Summaries for MIR4717 Gene

Entrez Gene Summary for MIR4717 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4717 Gene

MIR4717 (MicroRNA 4717) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4717 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4717 Gene

Genomics for MIR4717 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4717 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002275 Enhancer 0.3 Ensembl 250.7 +0.9 881 0.2 ZNF121 MIR4717 MIR3677HG lnc-RNPS1-1 RNPS1 ABCA3 MK280269-018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4717 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4717 Gene

Latest Assembly
chr16:2,274,620-2,274,691
(GRCh38/hg38)
Size:
72 bases
Orientation:
Plus strand

Previous Assembly
chr16:2,324,621-2,324,692
(GRCh37/hg19 by Entrez Gene)
Size:
72 bases
Orientation:
Plus strand

chr16:2,324,621-2,324,692
(GRCh37/hg19 by Ensembl)
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR4717 Gene

Genes around MIR4717 on UCSC Golden Path with GeneCards custom track
MIR4717 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4717 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4717 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4717 Gene

Proteins for MIR4717 Gene

Post-translational modifications for MIR4717 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4717 Gene

Domains & Families for MIR4717 Gene

Gene Families for MIR4717 Gene

HGNC:
genes like me logo Genes that share domains with MIR4717: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4717 Gene

Function for MIR4717 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4717 Gene

Localization for MIR4717 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4717 Gene

Pathways & Interactions for MIR4717 Gene

PathCards logo

SuperPathways for MIR4717 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4717 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4717 Gene

Drugs & Compounds for MIR4717 Gene

No Compound Related Data Available

Transcripts for MIR4717 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4717 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075EC4C_9606 precursor_RNA 72 3

RefSeq: NR_039868,

Ensembl: ENST00000584656 (view in UCSC) ,

miRBase: MI0017352,

URS000025DD6B_9606 miRNA 22 3

RefSeq: NR_039868,

miRBase: MIMAT0019829,

ENA: FR772995.1:1..22:ncRNA,

URS0000597BCD_9606 miRNA 21 3

RefSeq: NR_039868,

miRBase: MIMAT0019830,

ENA: FR772994.1:1..21:ncRNA,

MIR4717 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4717 Gene

No ASD Table

Relevant External Links for MIR4717 Gene

GeneLoc Exon Structure for
MIR4717

No data available for mRNA/cDNA for MIR4717 Gene

Expression for MIR4717 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4717

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4717 Gene

Orthologs for MIR4717 Gene

Evolution for MIR4717 Gene

ENSEMBL:
Gene Tree for MIR4717 (if available)
TreeFam:
Gene Tree for MIR4717 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4717

No data available for Orthologs for MIR4717 Gene

Paralogs for MIR4717 Gene

No data available for Paralogs for MIR4717 Gene

Variants for MIR4717 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4717 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4717 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv457353 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571201 CNV loss 21841781
nsv952902 CNV deletion 24416366

Additional Variant Information for MIR4717 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4717
Leiden Open Variation Database (LOVD)
MIR4717

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4717 Gene

Disorders for MIR4717 Gene

Additional Disease Information for MIR4717

No disorders were found for MIR4717 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4717 Gene

Publications for MIR4717 Gene

  1. Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum. (PMID: 30951563) Feng YY … Mao XH (PloS one 2019) 3
  2. MicroRNA expression profiling in Guillain-Barré syndrome. (PMID: 27836180) Lv Z … Wang Y (Journal of neuroimmunology 2016) 3
  3. microRNA-4717 differentially interacts with its polymorphic target in the PD1 3' untranslated region: A mechanism for regulating PD-1 expression and function in HBV-associated liver diseases. (PMID: 25895129) Zhang G … Liu Z (Oncotarget 2015) 3
  4. MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits. (PMID: 25847876) Hommers L … Deckert J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015) 3
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3

Products for MIR4717 Gene

Sources for MIR4717 Gene