microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4697 Gene

Data sources for MIR4697 Gene:

Subcategory (RNA class) for MIR4697 Gene

miRNA

Aliases for MIR4697 Gene

External Ids for MIR4697 Gene

Previous GeneCards Identifiers for MIR4697 Gene

  • GC11U901871
  • GC11M133771

Summaries for MIR4697 Gene

Entrez Gene Summary for MIR4697 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4697 Gene

MIR4697 (MicroRNA 4697) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4697 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4697 Gene

Genomics for MIR4697 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4697 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J133898 Enhancer 0.6 Ensembl ENCODE 250.7 -0.2 -172 0.5 CTCF NR2F1 ZNF143 TCF12 POLR2A MIR4697 piR-61504 lnc-IGSF9B-13 SPATA19 IGSF9B
GH11J133896 Enhancer 0.6 Ensembl ENCODE 0.7 +3.0 2980 2.4 BATF POLR2A TCF12 IGSF9B SPATA19 MIR4697 lnc-IGSF9B-13 LOC283172
GH11J133893 Enhancer 0.2 Ensembl 0.4 +5.9 5880 0.2 IGSF9B SPATA19 MIR4697 LOC283172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4697 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4697 Gene

Latest Assembly
chr11:133,898,504-133,898,581
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand

Previous Assembly
chr11:133,768,399-133,768,476
(GRCh37/hg19 by Entrez Gene)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR4697 Gene

Genes around MIR4697 on UCSC Golden Path with GeneCards custom track
MIR4697 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4697 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4697 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4697 Gene

Proteins for MIR4697 Gene

Post-translational modifications for MIR4697 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4697 Gene

Domains & Families for MIR4697 Gene

Gene Families for MIR4697 Gene

HGNC:
genes like me logo Genes that share domains with MIR4697: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4697 Gene

Function for MIR4697 Gene

Phenotypes From GWAS Catalog for MIR4697 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4697 Gene

Localization for MIR4697 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4697 Gene

Pathways & Interactions for MIR4697 Gene

PathCards logo

SuperPathways for MIR4697 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4697 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4697 Gene

Drugs & Compounds for MIR4697 Gene

No Compound Related Data Available

Transcripts for MIR4697 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4697 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C16F_9606 precursor_RNA 78 3

RefSeq: NR_039846,

Ensembl: ENST00000582977 (view in UCSC) ,

miRBase: MI0017330,

URS00003685CF_9606 miRNA 24 3

RefSeq: NR_039846,

miRBase: MIMAT0019792,

ENA: FR772959.1:1..24:ncRNA,

URS0000592E67_9606 miRNA 22 3

RefSeq: NR_039846,

miRBase: MIMAT0019791,

ENA: FR772960.1:1..22:ncRNA,

MIR4697 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4697 Gene

No ASD Table

Relevant External Links for MIR4697 Gene

GeneLoc Exon Structure for
MIR4697

No data available for mRNA/cDNA for MIR4697 Gene

Expression for MIR4697 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4697 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4697 Gene

This gene is overexpressed in Brain - Cerebellum (x5.9), Brain - Cerebellar Hemisphere (x4.8), and Esophagus - Gastroesophageal Junction (x4.2).
genes like me logo Genes that share expression patterns with MIR4697: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4697 Gene

Orthologs for MIR4697 Gene

Evolution for MIR4697 Gene

ENSEMBL:
Gene Tree for MIR4697 (if available)
TreeFam:
Gene Tree for MIR4697 (if available)

No data available for Orthologs for MIR4697 Gene

Paralogs for MIR4697 Gene

No data available for Paralogs for MIR4697 Gene

Variants for MIR4697 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4697 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4697 Gene

Variant ID Type Subtype PubMed ID
nsv1051677 CNV gain 25217958
nsv468900 CNV loss 19166990
nsv556595 CNV loss 21841781
nsv952765 CNV deletion 24416366

Additional Variant Information for MIR4697 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4697

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4697 Gene

Disorders for MIR4697 Gene

Additional Disease Information for MIR4697

No disorders were found for MIR4697 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4697 Gene

Publications for MIR4697 Gene

  1. Polymorphism in MIR4697 but not VPS13C, GCH1, or SIPA1L2 is associated with risk of Parkinson's disease in a Han Chinese population. (PMID: 28380328) Yang X … Xu Y (Neuroscience letters 2017) 3
  2. SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case-control study. (PMID: 27653855) Safaralizadeh T … Darvish H (Journal of the neurological sciences 2016) 3
  3. Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan. (PMID: 26804608) Chen CM … Wu YR (Neurobiology of aging 2016) 3
  4. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. (PMID: 25064009) Nalls MA … Singleton AB (Nature genetics 2014) 3
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3

Products for MIR4697 Gene

Sources for MIR4697 Gene