microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4691 Gene

Data sources for MIR4691 Gene:

RNA type for MIR4691 Gene

miRNA

Aliases for MIR4691 Gene

External Ids for MIR4691 Gene

Previous GeneCards Identifiers for MIR4691 Gene

  • GC11U901856
  • GC11P067805
  • GC11P067814

Summaries for MIR4691 Gene

Entrez Gene Summary for MIR4691 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4691 Gene

MIR4691 (MicroRNA 4691) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism.

Additional gene information for MIR4691 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4691 Gene

Genomics for MIR4691 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4691 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J068026 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -3.4 -3412 7.6 SP1 ZNF207 MYC IKZF1 JUND POLR2A ZNF10 BRCA1 ZIC2 CHD4 ENSG00000255306 NDUFS8 HSALNG0085209 ALDH3B1 PPP6R3 CHKA-DT TCIRG1 MIR4691 MIR7113 lnc-CHKA-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4691 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4691 Gene

Latest Assembly
chr11:68,033,897-68,033,981
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand

Previous Assembly
chr11:67,801,364-67,801,448
(GRCh37/hg19 by Entrez Gene)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR4691 Gene

Genes around MIR4691 on UCSC Golden Path with GeneCards custom track
MIR4691 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4691 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4691 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4691 Gene

Proteins for MIR4691 Gene

Post-translational modifications for MIR4691 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4691 Gene

Domains & Families for MIR4691 Gene

Gene Families for MIR4691 Gene

HGNC:
genes like me logo Genes that share domains with MIR4691: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4691 Gene

Function for MIR4691 Gene

Phenotypes From GWAS Catalog for MIR4691 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4691 Gene

Localization for MIR4691 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4691 Gene

Pathways & Interactions for MIR4691 Gene

genes like me logo Genes that share pathways with MIR4691: view

Gene Ontology (GO) - Biological Process for MIR4691 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4691 Gene

Drugs & Compounds for MIR4691 Gene

No Compound Related Data Available

Transcripts for MIR4691 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4691 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000012F9EC_9606 miRNA 23 5

RefSeq: NR_039840,

LncBase: hsa-miR-4691-3p,

miRBase: MIMAT0019782,

TarBase: hsa-miR-4691-3p,

ENA: FR772949.1:1..23:ncRNA, LM382553.1:1..23:ncRNA, LM611383.1:53..75:ncRNA,

URS000075C981_9606 pre_miRNA 85 4

RefSeq: NR_039840,

Ensembl: ENST00000583764 (view in UCSC) ,

miRBase: MI0017324,

ENA: LM611383.1:1..85:precursor_RNA,

URS00001067D1_9606 miRNA 23 3

RefSeq: NR_039840,

miRBase: MIMAT0019781,

ENA: FR772950.1:1..23:ncRNA, LM611383.1:14..36:ncRNA,

MIR4691 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4691 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4691 Gene

No ASD Table

Relevant External Links for MIR4691 Gene

GeneLoc Exon Structure for
MIR4691

Expression for MIR4691 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4691 Gene

genes like me logo Genes that share expression patterns with MIR4691: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4691 Gene

Orthologs for MIR4691 Gene

Evolution for MIR4691 Gene

ENSEMBL:
Gene Tree for MIR4691 (if available)
TreeFam:
Gene Tree for MIR4691 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4691

No data available for Orthologs for MIR4691 Gene

Paralogs for MIR4691 Gene

No data available for Paralogs for MIR4691 Gene

Variants for MIR4691 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4691 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4691 Gene

Variant ID Type Subtype PubMed ID
dgv1221n100 CNV gain 25217958
dgv1981n54 CNV gain 21841781
dgv1983n54 CNV loss 21841781
esv2759835 CNV gain+loss 17122850
nsv468606 CNV gain 19166990
nsv468615 CNV loss 19166990
nsv469856 CNV gain 16826518
nsv469964 CNV loss 18288195
nsv555278 CNV loss 21841781
nsv555282 CNV loss 21841781
nsv825963 CNV gain 20364138
nsv8836 CNV gain 18304495
nsv951026 CNV deletion 24416366

Additional Variant Information for MIR4691 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4691
Leiden Open Variation Database (LOVD)
MIR4691

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4691 Gene

Disorders for MIR4691 Gene

Additional Disease Information for MIR4691

No disorders were found for MIR4691 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4691 Gene

Publications for MIR4691 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4691 Gene

Sources for MIR4691 Gene