microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4687 Gene

Subcategory (RNA class) for MIR4687 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR4687 Gene

  • MicroRNA 4687 2 3 5
  • Hsa-Mir-4687 2 3
  • MIR4687 2 5
  • Hsa-MiR-4687-3p 173
  • Hsa-MiR-4687-5p 173
  • MIMAT0019775 50
  • MIMAT0019774 50
  • MI0017319 50

External Ids for MIR4687 Gene

Previous GeneCards Identifiers for MIR4687 Gene

  • GC11U901863
  • GC11P003887
  • GC11P003856
  • GC11P003859

Summaries for MIR4687 Gene

Entrez Gene Summary for MIR4687 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4687 Gene

MIR4687 (MicroRNA 4687) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Platelet homeostasis and Response to elevated platelet cytosolic Ca2+.

Additional gene information for MIR4687 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4687 Gene

Genomics for MIR4687 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4687 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003852 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.5 1458 9.9 SP1 HNRNPL GATAD2A CTCF PRDM10 RFX1 LEF1 IKZF1 NFKBIZ ZNF692 STIM1 MIR4687 STIM1-AS1 ENSG00000206976 OSBPL5 TSSC2 RHOG RRM1 PPIAP40 ENSG00000229368
GH11J003864 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 0.4 +10.4 10417 4.7 GATAD2A LEF1 IKZF1 JUND GABPA PKNOX1 RXRB SP1 ZNF24 DPF2 STIM1 ENSG00000206976 RHOG PPIAP40 RRM1 MIR4687 piR-32214-074
GH11J003876 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 0.4 +23.0 22997 4.7 ARHGAP35 GATAD2A TFE3 LEF1 IKZF1 RCOR2 BACH1 JUND MTA2 PKNOX1 STIM1 RHOG STIM1-AS1 ENSG00000229368 ENSG00000206976 RRM1 NUP98 OR52B4 CHRNA10 piR-32214-074
GH11J003871 Enhancer 0.9 ENCODE dbSUPER 0.4 +15.5 15514 1.1 IKZF1 LARP7 PKNOX1 ZNF24 IKZF2 BRD9 HDAC1 SOX6 TCF12 MGA ENSG00000206976 STIM1 piR-32214-074 MIR4687 RRM1
GH11J003873 Enhancer 0.7 dbSUPER 0.4 +17.8 17828 0.9 PRDM10 ZNF629 TCF7L2 DPF2 OSR2 ZBTB17 BCL11A WT1 IKZF1 NR2F1 ENSG00000206976 STIM1 piR-32214-074 MIR4687 RRM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4687 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4687 Gene

Genomic Locations for MIR4687 Gene
chr11:3,856,062-3,856,141
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr11:3,877,292-3,877,371
(GRCh37/hg19)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR4687 Gene

Genes around MIR4687 on UCSC Golden Path with GeneCards custom track
MIR4687 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4687 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4687 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4687 Gene

Proteins for MIR4687 Gene

Post-translational modifications for MIR4687 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4687 Gene

Domains & Families for MIR4687 Gene

Gene Families for MIR4687 Gene

HGNC:
genes like me logo Genes that share domains with MIR4687: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4687 Gene

Function for MIR4687 Gene

Phenotypes From GWAS Catalog for MIR4687 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4687 Gene

Localization for MIR4687 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4687 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4687 Gene

Pathways & Interactions for MIR4687 Gene

genes like me logo Genes that share pathways with MIR4687: view

Gene Ontology (GO) - Biological Process for MIR4687 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4687 Gene

Drugs & Compounds for MIR4687 Gene

No Compound Related Data Available

Transcripts for MIR4687 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4687 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B3CF_9606 precursor_RNA 80 4

HGNC: 41712,

RefSeq: NR_039835,

Ensembl: ENST00000583618 (view in UCSC) ,

miRBase: MI0017319,

URS00003B6938_9606 miRNA 22 4

RefSeq: NR_039835,

miRBase: MIMAT0019774,

TarBase: hsa-miR-4687-5p,

ENA: FR772944.1:1..22:ncRNA,

URS000047456A_9606 miRNA 21 4

RefSeq: NR_039835,

miRBase: MIMAT0019775,

TarBase: hsa-miR-4687-3p,

ENA: FR772943.1:1..21:ncRNA,

MIR4687 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4687 Gene

No ASD Table

Relevant External Links for MIR4687 Gene

GeneLoc Exon Structure for
MIR4687

No data available for mRNA/cDNA for MIR4687 Gene

Expression for MIR4687 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4687 Gene

genes like me logo Genes that share expression patterns with MIR4687: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4687 Gene

Orthologs for MIR4687 Gene

Evolution for MIR4687 Gene

ENSEMBL:
Gene Tree for MIR4687 (if available)
TreeFam:
Gene Tree for MIR4687 (if available)

No data available for Orthologs for MIR4687 Gene

Paralogs for MIR4687 Gene

No data available for Paralogs for MIR4687 Gene

Variants for MIR4687 Gene

Additional dbSNP identifiers (rs#s) for MIR4687 Gene

Additional Variant Information for MIR4687 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4687

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4687 Gene

Disorders for MIR4687 Gene

Additional Disease Information for MIR4687

No disorders were found for MIR4687 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4687 Gene

Publications for MIR4687 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4687 Gene

Sources for MIR4687 Gene