microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4687 Gene

Data sources for MIR4687 Gene:

RNA type for MIR4687 Gene

miRNA

Aliases for MIR4687 Gene

External Ids for MIR4687 Gene

Previous GeneCards Identifiers for MIR4687 Gene

  • GC11U901863
  • GC11P003887
  • GC11P003859
  • GC11P003857

Summaries for MIR4687 Gene

Entrez Gene Summary for MIR4687 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4687 Gene

MIR4687 (MicroRNA 4687) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cardiac conduction and Platelet homeostasis.

Additional gene information for MIR4687 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4687 Gene

Genomics for MIR4687 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4687 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4687 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4687 Gene

Latest Assembly
chr11:3,856,062-3,856,141
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand

Previous Assembly
chr11:3,877,292-3,877,371
(GRCh37/hg19 by Entrez Gene)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR4687 Gene

Genes around MIR4687 on UCSC Golden Path with GeneCards custom track
MIR4687 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4687 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4687 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4687 Gene

Proteins for MIR4687 Gene

Post-translational modifications for MIR4687 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4687 Gene

Domains & Families for MIR4687 Gene

Gene Families for MIR4687 Gene

HGNC:
genes like me logo Genes that share domains with MIR4687: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4687 Gene

Function for MIR4687 Gene

Phenotypes From GWAS Catalog for MIR4687 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4687 Gene

Localization for MIR4687 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4687 gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR4687 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIR4687: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR4687 Gene

Pathways & Interactions for MIR4687 Gene

genes like me logo Genes that share pathways with MIR4687: view

Gene Ontology (GO) - Biological Process for MIR4687 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4687 Gene

Drugs & Compounds for MIR4687 Gene

No Compound Related Data Available

Transcripts for MIR4687 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4687 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003B6938_9606 miRNA 22 4

RefSeq: NR_039835,

miRBase: MIMAT0019774,

TarBase: hsa-miR-4687-5p,

ENA: FR772944.1:1..22:ncRNA,

URS000047456A_9606 miRNA 21 4

RefSeq: NR_039835,

miRBase: MIMAT0019775,

TarBase: hsa-miR-4687-3p,

ENA: FR772943.1:1..21:ncRNA,

URS000075B3CF_9606 precursor_RNA 80 3

RefSeq: NR_039835,

Ensembl: ENST00000583618 (view in UCSC) ,

miRBase: MI0017319,

MIR4687 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4687 Gene

No ASD Table

Relevant External Links for MIR4687 Gene

GeneLoc Exon Structure for
MIR4687

No data available for mRNA/cDNA for MIR4687 Gene

Expression for MIR4687 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4687 Gene

genes like me logo Genes that share expression patterns with MIR4687: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4687 Gene

Orthologs for MIR4687 Gene

Evolution for MIR4687 Gene

ENSEMBL:
Gene Tree for MIR4687 (if available)
TreeFam:
Gene Tree for MIR4687 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4687

No data available for Orthologs for MIR4687 Gene

Paralogs for MIR4687 Gene

No data available for Paralogs for MIR4687 Gene

Variants for MIR4687 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4687 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR4687 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4687
Leiden Open Variation Database (LOVD)
MIR4687

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4687 Gene

Disorders for MIR4687 Gene

Additional Disease Information for MIR4687

No disorders were found for MIR4687 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4687 Gene

Publications for MIR4687 Gene

  1. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4687 Gene

Sources for MIR4687 Gene