microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4686 Gene

Subcategory (RNA class) for MIR4686 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4686 Gene

  • MicroRNA 4686 2 3 5
  • Hsa-Mir-4686 2 3
  • MIR4686 2 5
  • MIMAT0019773 50
  • MI0017318 50

External Ids for MIR4686 Gene

Previous GeneCards Identifiers for MIR4686 Gene

  • GC11U901874
  • GC11P002196

Summaries for MIR4686 Gene

Entrez Gene Summary for MIR4686 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4686 Gene

MIR4686 (MicroRNA 4686) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4686 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4686 Gene

Genomics for MIR4686 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4686 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002171 Promoter/Enhancer 0.6 EPDnew CraniofacialAtlas 600.7 -1.4 -1392 0.6 ZNF24 MIR4686 TH lnc-INS-3 ENSG00000236710 lnc-INS-2 INS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4686 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4686 Gene

Genomic Locations for MIR4686 Gene
chr11:2,173,063-2,173,138
(GRCh38/hg38)
Size:
76 bases
Orientation:
Plus strand
chr11:2,194,293-2,194,368
(GRCh37/hg19)
Size:
76 bases
Orientation:
Plus strand

Genomic View for MIR4686 Gene

Genes around MIR4686 on UCSC Golden Path with GeneCards custom track
MIR4686 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4686 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4686 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4686 Gene

Proteins for MIR4686 Gene

Post-translational modifications for MIR4686 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4686 Gene

Domains & Families for MIR4686 Gene

Gene Families for MIR4686 Gene

HGNC:
genes like me logo Genes that share domains with MIR4686: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4686 Gene

Function for MIR4686 Gene

Phenotypes From GWAS Catalog for MIR4686 Gene

Gene Ontology (GO) - Molecular Function for MIR4686 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 30451334
genes like me logo Genes that share ontologies with MIR4686: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4686 Gene

Localization for MIR4686 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4686 Gene

Pathways & Interactions for MIR4686 Gene

PathCards logo

SuperPathways for MIR4686 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4686 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 30451334
genes like me logo Genes that share ontologies with MIR4686: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4686 Gene

Drugs & Compounds for MIR4686 Gene

No Compound Related Data Available

Transcripts for MIR4686 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4686 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D716_9606 precursor_RNA 76 4

HGNC: 41601,

RefSeq: NR_039834,

Ensembl: ENST00000584128 (view in UCSC) ,

miRBase: MI0017318,

URS000059225F_9606 miRNA 23 3

RefSeq: NR_039834,

miRBase: MIMAT0019773,

ENA: FR772942.1:1..23:ncRNA,

MIR4686 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4686 Gene

No ASD Table

Relevant External Links for MIR4686 Gene

GeneLoc Exon Structure for
MIR4686

No data available for mRNA/cDNA for MIR4686 Gene

Expression for MIR4686 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4686 Gene

genes like me logo Genes that share expression patterns with MIR4686: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4686 Gene

Orthologs for MIR4686 Gene

Evolution for MIR4686 Gene

ENSEMBL:
Gene Tree for MIR4686 (if available)
TreeFam:
Gene Tree for MIR4686 (if available)

No data available for Orthologs for MIR4686 Gene

Paralogs for MIR4686 Gene

No data available for Paralogs for MIR4686 Gene

Variants for MIR4686 Gene

Additional dbSNP identifiers (rs#s) for MIR4686 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4686 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV gain 19166990
nsv469927 CNV loss 18288195
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv553070 CNV loss 21841781
nsv553079 CNV loss 21841781
nsv951284 CNV deletion 24416366

Additional Variant Information for MIR4686 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4686

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4686 Gene

Disorders for MIR4686 Gene

No disorders were found for MIR4686 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4686 Gene

Publications for MIR4686 Gene

  1. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2019) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4686 Gene

Sources for MIR4686 Gene