microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4685 Gene

Subcategory (RNA class) for MIR4685 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR4685 Gene

  • MicroRNA 4685 2 3 5
  • Hsa-MiR-4685-3p 166 177
  • Hsa-Mir-4685 3
  • MIMAT0019771 51
  • MIMAT0019772 51
  • MI0017317 51
  • MIR4685 2

External Ids for MIR4685 Gene

Previous GeneCards Identifiers for MIR4685 Gene

  • GC10U901546
  • GC10M100194

Summaries for MIR4685 Gene

Entrez Gene Summary for MIR4685 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4685 Gene

MIR4685 (MicroRNA 4685) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4685 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4685 Gene

Genomics for MIR4685 Gene

GeneHancer (GH) Regulatory Elements for MIR4685 Gene

Promoters and enhancers for MIR4685 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J098434 Enhancer 0.6 Ensembl 0.7 -3.4 -3440 0.8 FOS CTBP1 ZNF592 JUND PKNOX1 DPF2 JUN ZNF687 SMARCE1 FOSL2 HPS1 MIR4685 piR-52294-018
GH10J098423 Enhancer 0.8 Ensembl ENCODE 0.4 +6.6 6599 2.7 CTCF REST RAD21 TRIM22 SMC3 ZSCAN9 MYC TFDP1 YY1 POLR2G PYROXD2 RF00017-769 MIR4685 HPS1
GH10J098438 Enhancer 0.4 Ensembl 0.4 -7.2 -7241 0.4 ZNF585B ATF4 ATF3 ATF7 piR-52294-018 PYROXD2 HPS1 MIR4685
GH10J098426 Enhancer 0.3 Ensembl 0.7 +5.0 4959 0.4 CTCF MIR4685 RF00017-769 HPS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4685 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4685 Gene

Genomic Locations for MIR4685 Gene
chr10:98,431,292-98,431,360
(GRCh38/hg38)
Size:
69 bases
Orientation:
Minus strand
chr10:100,191,039-100,191,117
(GRCh37/hg19)
Size:
79 bases
Orientation:
Minus strand

Genomic View for MIR4685 Gene

Genes around MIR4685 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4685 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4685 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4685 Gene

Proteins for MIR4685 Gene

Post-translational modifications for MIR4685 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4685 Gene

Domains & Families for MIR4685 Gene

Gene Families for MIR4685 Gene

HGNC:
genes like me logo Genes that share domains with MIR4685: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4685 Gene

Function for MIR4685 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4685 Gene

Localization for MIR4685 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4685 Gene

Pathways & Interactions for MIR4685 Gene

PathCards logo

SuperPathways for MIR4685 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4685 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4685 Gene

Drugs & Compounds for MIR4685 Gene

No Compound Related Data Available

Transcripts for MIR4685 Gene

mRNA/cDNA for MIR4685 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
2 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4685 Gene

No ASD Table

Relevant External Links for MIR4685 Gene

GeneLoc Exon Structure for
MIR4685

Expression for MIR4685 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4685 Gene

genes like me logo Genes that share expression patterns with MIR4685: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4685 Gene

Orthologs for MIR4685 Gene

Evolution for MIR4685 Gene

ENSEMBL:
Gene Tree for MIR4685 (if available)
TreeFam:
Gene Tree for MIR4685 (if available)

No data available for Orthologs for MIR4685 Gene

Paralogs for MIR4685 Gene

No data available for Paralogs for MIR4685 Gene

Variants for MIR4685 Gene

Additional dbSNP identifiers (rs#s) for MIR4685 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4685 Gene

Variant ID Type Subtype PubMed ID
nsv515723 CNV loss 19592680
nsv524427 CNV loss 19592680
nsv831955 CNV gain 17160897

Additional Variant Information for MIR4685 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4685

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4685 Gene

Disorders for MIR4685 Gene

Additional Disease Information for MIR4685

No disorders were found for MIR4685 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4685 Gene

Publications for MIR4685 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4685 Gene

Sources for MIR4685 Gene