microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4684 Gene

Subcategory (RNA class) for MIR4684 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4684 Gene

  • MicroRNA 4684 2 3 5
  • Hsa-Mir-4684 2 3
  • MIR4684 2 5
  • MIMAT0019770 50
  • MIMAT0019769 50
  • MI0017316 50

External Ids for MIR4684 Gene

Previous GeneCards Identifiers for MIR4684 Gene

  • GC01U903289
  • GC01P023049

Summaries for MIR4684 Gene

Entrez Gene Summary for MIR4684 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4684 Gene

MIR4684 (MicroRNA 4684) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4684 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4684 Gene

Genomics for MIR4684 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4684 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J022710 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -8.1 -8056 3.3 PRDM10 ZNF692 RELA ZIC2 POLR2A PATZ1 TCF12 ZNF740 IKZF2 ZNF600 EPHB2 ENSG00000225952 TCEA3 KDM1A MIR4684 LACTBL1
GH01J022716 Enhancer 0.7 Ensembl dbSUPER 0.7 -2.2 -2216 1.4 ZIC2 NRF1 NFE2 ZNF423 FEZF1 GLIS1 ZMYM3 CBFA2T2 GATA2 CBFA2T3 EPHB2 MIR4684 LACTBL1
GH01J022735 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +18.8 18783 9 JUND ZIC2 PKNOX1 ZNF24 HDAC1 ZNF600 SCRT2 NRF1 SP1 UBTF ENSG00000225952 EPHB2 LINC00339 HSALNG0001601 MIR4684 LACTBL1
GH01J022731 Enhancer 0.6 Ensembl dbSUPER 0.4 +10.8 10784 0.6 ZIC2 NFIC ZFHX2 NFIB SMARCA4 EGR2 HSALNG0001601 MIR4684 EPHB2 LACTBL1
GH01J022732 Enhancer 0.6 Ensembl 0.4 +12.6 12572 0.3 CTCF ZNF444 ZFHX2 BCOR RAD21 SMARCA5 ZNF768 GLIS1 ZNF143 ZFP36 HSALNG0001601 MIR4684 EPHB2 LACTBL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4684 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4684 Gene

Genomic Locations for MIR4684 Gene
chr1:22,719,517-22,719,598
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr1:23,046,010-23,046,091
(GRCh37/hg19)
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR4684 Gene

Genes around MIR4684 on UCSC Golden Path with GeneCards custom track
MIR4684 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4684 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4684 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4684 Gene

Proteins for MIR4684 Gene

Post-translational modifications for MIR4684 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4684 Gene

Domains & Families for MIR4684 Gene

Gene Families for MIR4684 Gene

HGNC:
genes like me logo Genes that share domains with MIR4684: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4684 Gene

Function for MIR4684 Gene

Phenotypes From GWAS Catalog for MIR4684 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4684 Gene

Localization for MIR4684 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4684 Gene

Pathways & Interactions for MIR4684 Gene

PathCards logo

SuperPathways for MIR4684 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4684 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4684 Gene

Drugs & Compounds for MIR4684 Gene

No Compound Related Data Available

Transcripts for MIR4684 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4684 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C836_9606 precursor_RNA 82 4

HGNC: 41695,

RefSeq: NR_039832,

Ensembl: ENST00000581646 (view in UCSC) ,

miRBase: MI0017316,

URS00003570D1_9606 miRNA 22 3

RefSeq: NR_039832,

miRBase: MIMAT0019769,

ENA: FR772939.1:1..22:ncRNA,

URS000052AB63_9606 miRNA 22 3

RefSeq: NR_039832,

miRBase: MIMAT0019770,

ENA: FR772938.1:1..22:ncRNA,

MIR4684 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4684 Gene

No ASD Table

Relevant External Links for MIR4684 Gene

GeneLoc Exon Structure for
MIR4684

No data available for mRNA/cDNA for MIR4684 Gene

Expression for MIR4684 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4684 Gene

Orthologs for MIR4684 Gene

Evolution for MIR4684 Gene

ENSEMBL:
Gene Tree for MIR4684 (if available)
TreeFam:
Gene Tree for MIR4684 (if available)

No data available for Orthologs for MIR4684 Gene

Paralogs for MIR4684 Gene

No data available for Paralogs for MIR4684 Gene

Variants for MIR4684 Gene

Additional dbSNP identifiers (rs#s) for MIR4684 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4684 Gene

Variant ID Type Subtype PubMed ID
esv34161 CNV loss 18971310

Additional Variant Information for MIR4684 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4684

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4684 Gene

Disorders for MIR4684 Gene

No disorders were found for MIR4684 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4684 Gene

Publications for MIR4684 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen TB … Bramsen JB (RNA biology 2011) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4684 Gene

Sources for MIR4684 Gene