microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4680 Gene

Subcategory (RNA class) for MIR4680 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4680 Gene

  • MicroRNA 4680 2 3 5
  • Hsa-Mir-4680 2 3
  • MIR4680 2 5
  • MIMAT0019765 50
  • MIMAT0019764 50
  • MI0017312 50

External Ids for MIR4680 Gene

Previous GeneCards Identifiers for MIR4680 Gene

  • GC10U901549
  • GC10P112660

Summaries for MIR4680 Gene

Entrez Gene Summary for MIR4680 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4680 Gene

MIR4680 (MicroRNA 4680) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Interferon type I signaling pathways.

Additional gene information for MIR4680 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4680 Gene

Genomics for MIR4680 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4680 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J110897 Enhancer 0.7 Ensembl dbSUPER 600.7 -0.7 -689 0.4 SP1 FOXA2 YY1 RBM22 JUND RAD21 HNF4A RXRA MAX HNF4G MIR4680 PDCD4 ENSG00000232470 ADRA2A ENSG00000270589 NONHSAG006867.2 BBIP1
GH10J110895 Enhancer 0.4 Ensembl dbSUPER 600.7 -1.5 -1489 0.4 PRDM1 MIR4680 PDCD4 ENSG00000232470 NONHSAG006867.2 BBIP1
GH10J110898 Enhancer 0.3 Ensembl 600.7 +0.3 311 0.4 ZNF362 MIR4680 PDCD4 ENSG00000232470 SHOC2 ENSG00000270589 piR-37651 NONHSAG006867.2 BBIP1
GH10J110893 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.7 -4.8 -4789 1.4 CTCF PRDM10 REST RAD21 CEBPB SMC3 ZNF654 RB1 TRIM22 PDCD4 ENSG00000232470 SHOC2 ADRA2A MIR4680 NONHSAG006867.2 BBIP1
GH10J110891 Enhancer 0.2 Ensembl 0.4 -6.6 -6589 0.2 NONHSAG006867.2 ENSG00000232470 SHOC2 ENSG00000270589 MIR4680 PDCD4 BBIP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4680 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4680 Gene

Genomic Locations for MIR4680 Gene
chr10:110,898,090-110,898,155
(GRCh38/hg38)
Size:
66 bases
Orientation:
Plus strand
chr10:112,657,843-112,657,916
(GRCh37/hg19)
Size:
74 bases
Orientation:
Plus strand

Genomic View for MIR4680 Gene

Genes around MIR4680 on UCSC Golden Path with GeneCards custom track
MIR4680 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4680 Gene

Proteins for MIR4680 Gene

Post-translational modifications for MIR4680 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4680 Gene

Domains & Families for MIR4680 Gene

Gene Families for MIR4680 Gene

HGNC:
genes like me logo Genes that share domains with MIR4680: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4680 Gene

Function for MIR4680 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4680 Gene

Localization for MIR4680 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4680 Gene

Pathways & Interactions for MIR4680 Gene

PathCards logo

SuperPathways for MIR4680 Gene

genes like me logo Genes that share pathways with MIR4680: view

Pathways by source for MIR4680 Gene

1 BioSystems pathway for MIR4680 Gene

Gene Ontology (GO) - Biological Process for MIR4680 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4680 Gene

Drugs & Compounds for MIR4680 Gene

No Compound Related Data Available

Transcripts for MIR4680 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4680 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B9E0_9606 precursor_RNA 66 4

HGNC: 41541,

RefSeq: NR_039828,

Ensembl: ENST00000580906 (view in UCSC) ,

miRBase: MI0017312,

URS0000217BB7_9606 miRNA 23 3

RefSeq: NR_039828,

miRBase: MIMAT0019764,

ENA: FR772934.1:1..23:ncRNA,

URS00005CFD69_9606 miRNA 21 3

RefSeq: NR_039828,

miRBase: MIMAT0019765,

ENA: FR772933.1:1..21:ncRNA,

MIR4680 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4680 Gene

No ASD Table

Relevant External Links for MIR4680 Gene

GeneLoc Exon Structure for
MIR4680

No data available for mRNA/cDNA for MIR4680 Gene

Expression for MIR4680 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4680 Gene

genes like me logo Genes that share expression patterns with MIR4680: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4680 Gene

Orthologs for MIR4680 Gene

Evolution for MIR4680 Gene

ENSEMBL:
Gene Tree for MIR4680 (if available)
TreeFam:
Gene Tree for MIR4680 (if available)

No data available for Orthologs for MIR4680 Gene

Paralogs for MIR4680 Gene

No data available for Paralogs for MIR4680 Gene

Variants for MIR4680 Gene

Additional dbSNP identifiers (rs#s) for MIR4680 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4680 Gene

Variant ID Type Subtype PubMed ID
nsv1035602 CNV loss 25217958
nsv1069515 CNV deletion 25765185
nsv7211 OTHER inversion 18451855
nsv831985 CNV gain+loss 17160897

Additional Variant Information for MIR4680 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4680 Gene

Disorders for MIR4680 Gene

Additional Disease Information for MIR4680

No disorders were found for MIR4680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4680 Gene

Publications for MIR4680 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4680 Gene

Sources for MIR4680 Gene