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Aliases for MIR4674 Gene

Subcategory (RNA class) for MIR4674 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4674 Gene

  • MicroRNA 4674 2 3 5
  • Hsa-Mir-4674 3

External Ids for MIR4674 Gene

Previous GeneCards Identifiers for MIR4674 Gene

  • GC09U901721
  • GC09M139442

Summaries for MIR4674 Gene

Entrez Gene Summary for MIR4674 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4674 Gene

MIR4674 (MicroRNA 4674) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4674 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4674 Gene

Genomics for MIR4674 Gene

GeneHancer (GH) Regulatory Elements for MIR4674 Gene

Promoters and enhancers for MIR4674 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I136537 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.8 +3.0 2973 10.7 HDGF PKNOX1 CLOCK SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 ZNF207 NOTCH1 ENSG00000227512 NALT1 SEC16A SDCCAG3 C9orf163 SNHG7 INPP5E ANAPC2 FUT7
GH09I136549 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.6 -5584 4.5 HDGF GLIS2 ZNF416 FOS SP3 SMARCB1 ZNF623 ATF4 SMARCA4 NBN INPP5E SEC16A C9orf163 TMEM203 NOTCH1 NALT1 SDCCAG3 TMEM141 MIR4674 LINC01451
GH09I136563 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 0.3 -22.3 -22283 10.7 HDGF CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A YBX1 ZBTB7B IRF4 EXD3 INPP5E ANAPC2 QSOX2 SNHG7 SNAPC4 SDCCAG3 MAN1B1 SEC16A NOTCH1
GH09I136586 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -41.9 -41884 3.5 ATF1 SIN3A ETS1 TCF12 ZNF766 GLIS2 ARID2 ZNF143 ATF7 REST NALT1 ENSG00000227512 C9orf163 LINC01451 MIR4674
GH09I136550 Enhancer 0.6 ENCODE dbSUPER 0.8 -3.3 -3267 0.2 GLIS2 ZBTB48 ZIC2 C9orf163 SEC16A INPP5E NALT1 MIR4674 LINC01451
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4674 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4674 Gene

Genomic Locations for MIR4674 Gene
chr9:136,546,173-136,546,259
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr9:139,440,625-139,440,711
(GRCh37/hg19)

Genomic View for MIR4674 Gene

Genes around MIR4674 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4674 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4674 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4674 Gene

ORGUL Member Location for MIR4674 Gene

ORGUL Member Location for MIR4674 gene

Proteins for MIR4674 Gene

Post-translational modifications for MIR4674 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4674 Gene

Domains & Families for MIR4674 Gene

Gene Families for MIR4674 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4674: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4674 Gene

Function for MIR4674 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4674 Gene

Localization for MIR4674 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4674 Gene

Pathways & Interactions for MIR4674 Gene

SuperPathways for MIR4674 Gene

No Data Available

Interacting Proteins for MIR4674 Gene

Gene Ontology (GO) - Biological Process for MIR4674 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4674 Gene

Drugs & Compounds for MIR4674 Gene

No Compound Related Data Available

Transcripts for MIR4674 Gene

mRNA/cDNA for MIR4674 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4674 Gene

No ASD Table

Relevant External Links for MIR4674 Gene

GeneLoc Exon Structure for
MIR4674
ECgene alternative splicing isoforms for
MIR4674

Expression for MIR4674 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4674 Gene:

MIR4674
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4674 Gene

Orthologs for MIR4674 Gene

Evolution for MIR4674 Gene

ENSEMBL:
Gene Tree for MIR4674 (if available)
TreeFam:
Gene Tree for MIR4674 (if available)

No data available for Orthologs for MIR4674 Gene

Paralogs for MIR4674 Gene

No data available for Paralogs for MIR4674 Gene

Variants for MIR4674 Gene

Sequence variations from dbSNP and Humsavar for MIR4674 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs878855023 uncertain-significance, Adams-Oliver syndrome 5, not specified 136,545,769(-) CG/AA downstream_transcript_variant
rs1002164447 -- 136,546,604(-) G/T upstream_transcript_variant
rs1002659444 -- 136,546,064(-) G/A/C downstream_transcript_variant
rs1002684206 -- 136,547,284(-) G/A upstream_transcript_variant
rs1003144942 -- 136,547,091(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4674 Gene

Variant ID Type Subtype PubMed ID
esv2759720 CNV loss 17122850
esv30005 CNV loss 17803354
nsv1161916 CNV deletion 26073780
nsv1161917 CNV deletion 26073780
nsv466673 CNV gain 19166990
nsv469918 CNV loss 18288195
nsv509334 CNV insertion 20534489
nsv615965 CNV loss 21841781
nsv615966 CNV gain 21841781
nsv615967 CNV loss 21841781
nsv6768 CNV insertion 18451855
nsv8579 CNV gain 18304495
nsv951202 CNV deletion 24416366

Additional Variant Information for MIR4674 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4674

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4674 Gene

Disorders for MIR4674 Gene

Additional Disease Information for MIR4674

No disorders were found for MIR4674 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4674 Gene

Publications for MIR4674 Gene

  1. MicroRNA hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer. (PMID: 27265126) Knyazev EN … Shkurnikov MY (Bulletin of experimental biology and medicine 2016) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4674 Gene

Sources for MIR4674 Gene

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