microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4668 Gene

Subcategory (RNA class) for MIR4668 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4668 Gene

  • MicroRNA 4668 2 3 5
  • Hsa-Mir-4668 2 3
  • MIR4668 2 5
  • MIMAT0019745 50
  • MIMAT0019746 50
  • MI0017298 50
  • Mir-4668 3

External Ids for MIR4668 Gene

Previous GeneCards Identifiers for MIR4668 Gene

  • GC09U901716
  • GC09P114696

Summaries for MIR4668 Gene

Entrez Gene Summary for MIR4668 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4668 Gene

MIR4668 (MicroRNA 4668) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4668 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4668 Gene

Genomics for MIR4668 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4668 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J111923 Enhancer 1 ENCODE dbSUPER 0.7 -4.7 -4658 7.1 CEBPG SP1 POLR2A STAT3 PRDM1 RELA TCF12 IKZF2 TRIM22 PKNOX1 NONHSAG053204.2 UGCG GNG10 MIR4668 SUSD1
GH09J111935 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +6.9 6901 6.8 POLR2A RELA SMAD5 IKZF2 TRIM22 YY1 PKNOX1 MCM7 EED ARID3A RNU6-710P RNU6-1013P GNG10 SHOC1 KIAA1958 PTGR1 PTBP3 SUSD1 DNAJC25 HSDL2
GH09J111942 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 +12.4 12361 3.9 RELA TCF12 IKZF2 PKNOX1 EED DPF2 RELB CEBPB RUNX3 GATAD2B UGCG RNU6-710P RNU6-1013P GNG10 DNAJC25 lnc-SUSD1-7 MIR4668 SUSD1
GH09J111934 Enhancer 0.6 Ensembl dbSUPER 0.7 +2.8 2801 0.2 SP1 YY1 HNF4A RXRA HNF4G MIR4668 lnc-SUSD1-7 UGCG SUSD1
GH09J111949 Enhancer 0.6 Ensembl dbSUPER 0.4 +17.0 17001 3.4 PRDM1 RELA ZBTB33 ZNF384 MLLT1 IKZF1 UGCG RNU6-1013P GNG10 lnc-SUSD1-7 MIR4668 SUSD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4668 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4668 Gene

Genomic Locations for MIR4668 Gene
chr9:111,932,100-111,932,169
(GRCh38/hg38)
Size:
70 bases
Orientation:
Plus strand
chr9:114,694,380-114,694,449
(GRCh37/hg19)
Size:
70 bases
Orientation:
Plus strand

Genomic View for MIR4668 Gene

Genes around MIR4668 on UCSC Golden Path with GeneCards custom track
MIR4668 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4668 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4668 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4668 Gene

Proteins for MIR4668 Gene

Post-translational modifications for MIR4668 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4668 Gene

Domains & Families for MIR4668 Gene

Gene Families for MIR4668 Gene

HGNC:
genes like me logo Genes that share domains with MIR4668: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4668 Gene

Function for MIR4668 Gene

Phenotypes From GWAS Catalog for MIR4668 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4668 Gene

Localization for MIR4668 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4668 Gene

Pathways & Interactions for MIR4668 Gene

PathCards logo

SuperPathways for MIR4668 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4668 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4668 Gene

Drugs & Compounds for MIR4668 Gene

No Compound Related Data Available

Transcripts for MIR4668 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4668 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E82F_9606 precursor_RNA 70 5

HGNC: 41545,

RefSeq: NR_039814,

Ensembl: ENST00000582284 (view in UCSC) ,

miRBase: MI0017298,

ENA: LM611378.1:1..70:precursor_RNA,

URS0000065FDF_9606 miRNA 23 3

RefSeq: NR_039814,

miRBase: MIMAT0019746,

ENA: FR772915.1:1..23:ncRNA, LM611378.1:48..70:ncRNA,

URS00000A17E7_9606 miRNA 23 3

RefSeq: NR_039814,

miRBase: MIMAT0019745,

ENA: FR772916.1:1..23:ncRNA, LM382547.1:1..23:ncRNA, LM611378.1:1..23:ncRNA,

MIR4668 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4668 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4668 Gene

No ASD Table

Relevant External Links for MIR4668 Gene

GeneLoc Exon Structure for
MIR4668

Expression for MIR4668 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4668 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4668

genes like me logo Genes that share expression patterns with MIR4668: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4668 Gene

Orthologs for MIR4668 Gene

Evolution for MIR4668 Gene

ENSEMBL:
Gene Tree for MIR4668 (if available)
TreeFam:
Gene Tree for MIR4668 (if available)

No data available for Orthologs for MIR4668 Gene

Paralogs for MIR4668 Gene

No data available for Paralogs for MIR4668 Gene

Variants for MIR4668 Gene

Additional dbSNP identifiers (rs#s) for MIR4668 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4668 Gene

Variant ID Type Subtype PubMed ID
nsv831690 CNV loss 17160897

Additional Variant Information for MIR4668 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4668

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4668 Gene

Disorders for MIR4668 Gene

No disorders were found for MIR4668 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4668 Gene

Publications for MIR4668 Gene

  1. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  2. Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. (PMID: 29426937) Guo J … Li J (Nature communications 2018) 3
  3. Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10. (PMID: 26151773) Li Q … Mao XH (Autophagy 2015) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3

Products for MIR4668 Gene

Sources for MIR4668 Gene