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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR4668 Gene
Data sources for MIR4668 Gene:
Subcategory (RNA class) for MIR4668 Gene
miRNA
Aliases for MIR4668 Gene
- MicroRNA 4668 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-Mir-4668 (HGNC, NCBI Entrez Gene)
- MIMAT0019745 (miRBase)
- MIMAT0019746 (miRBase)
- MI0017298 (miRBase)
- Mir-4668 (NCBI Entrez Gene)
- MIR4668 (Ensembl)
External Ids for MIR4668 Gene
- HGNC: 41545
- NCBI Entrez Gene: 100616114
- Ensembl: ENSG00000266315
- miRBase: hsa-mir-4668
Previous GeneCards Identifiers for MIR4668 Gene
- GC09U901716
- GC09P114696
Summaries for MIR4668 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4668 Gene
MIR4668 (MicroRNA 4668) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR4668 Gene
- HGNC (41545)
- NCBI Entrez Gene (100616114)
- Ensembl (ENSG00000266315)
- Open Targets Platform(ENSG00000266315)
- Search for MIR4668 at DataMed
- Search for MIR4668 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4668 Gene
Genomics for MIR4668 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR4668 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J111923 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 0.7 | -4.8 | -4811 | 7.4 | SP1 BCL11A NR2C1 POLR2A CEBPB SIN3A GABPA IRF4 RXRA EBF1 | NONHSAG053204.2 UGCG GNG10 MIR4668 SUSD1 | |
| GH09J111935 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +5.7 | 5701 | 4.4 | BCL11A POLR2A IRF4 TRIM22 RXRA EBF1 TAF1 BHLHE40 BATF MYC | RNU6-710P RNU6-1013P GNG10 KIAA1958 SHOC1 PTBP3 SUSD1 DNAJC25 HSDL2 MIR4668 | |
| GH09J111940 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 0.4 | +9.0 | 9047 | 0.8 | ZC3H11A RXRA | RNU6-710P GNG10 SHOC1 HSALNG0073734 MIR4668 UGCG SUSD1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR4668 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR4668 Gene
Latest Assembly
- chr9:111,932,100-111,932,169
- (GRCh38/hg38)
- Size:
- 70 bases
- Orientation:
- Plus strand
Previous Assembly
- chr9:114,694,380-114,694,449
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 70 bases
- Orientation:
- Plus strand
- chr9:114,694,380-114,694,449
- (GRCh37/hg19 by Ensembl)
- Size:
- 70 bases
- Orientation:
- Plus strand
Genomic View for MIR4668 Gene
Genes around MIR4668 on UCSC Golden Path with GeneCards custom track
MIR4668 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 9q31.3 by HGNC
- 9q31.3 by Entrez Gene
- 9q31.3 by Ensembl
MIR4668 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR4668 Gene
Proteins for MIR4668 Gene
Post-translational modifications for MIR4668 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR4668 Gene
Domains & Families for MIR4668 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4668 Gene
Function for MIR4668 Gene
Phenotypes From GWAS Catalog for MIR4668 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4668 - Starting at $85 >
- * MIR4668 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4668 - Starting at $45 >
- * MIR4668 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4668 Gene
Localization for MIR4668 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4668 Gene
Transcripts for MIR4668 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4668 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075E82F_9606 | precursor_RNA | 70 | 4 |
RefSeq: NR_039814, Ensembl: ENST00000582284 (view in UCSC) , miRBase: MI0017298, |
| URS0000065FDF_9606 | miRNA | 23 | 3 |
RefSeq: NR_039814, miRBase: MIMAT0019746, |
| URS00000A17E7_9606 | miRNA | 23 | 3 |
RefSeq: NR_039814, miRBase: MIMAT0019745, ENA: FR772916.1:1..23:ncRNA, LM382547.1:1..23:ncRNA, LM611378.1:1..23:ncRNA, |
MIR4668 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR4668 Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4668 - Starting at $85 >
- * MIR4668 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4668 - Starting at $45 >
- * MIR4668 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR4668 Gene
- GeneLoc Exon Structure for
- MIR4668
Expression for MIR4668 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4668
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4668 Gene
Orthologs for MIR4668 Gene
No data available for Orthologs for MIR4668 Gene
Paralogs for MIR4668 Gene
No data available for Paralogs for MIR4668 Gene
Variants for MIR4668 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR4668 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4668
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4668 Gene
Disorders for MIR4668 Gene
Additional Disease Information for MIR4668
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for MIR4668 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4668 Gene
Publications for MIR4668 Gene
- Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
- Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. (PMID: 29426937) Guo J … Li J (Nature communications 2018) 3
- Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10. (PMID: 26151773) Li Q … Mao XH (Autophagy 2015) 3
- miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
- Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
ExternalLinks
Products for MIR4668 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4668
- Origene Custom Protein Services for MIR4668
- Browse OriGene Inhibitory RNA Products For MIR4668
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR4668
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR4668
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR4668
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR4668
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR4668
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR4668
Sources for MIR4668 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB