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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4668 (MicroRNA 4668) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J111923 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 0.7 | -4.8 | -4811 | 7.4 | SP1 BCL11A NR2C1 POLR2A CEBPB SIN3A GABPA IRF4 RXRA EBF1 | NONHSAG053204.2 UGCG GNG10 MIR4668 SUSD1 | |
GH09J111935 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +5.7 | 5701 | 4.4 | BCL11A POLR2A IRF4 TRIM22 RXRA EBF1 TAF1 BHLHE40 BATF MYC | RNU6-710P RNU6-1013P GNG10 KIAA1958 SHOC1 PTBP3 SUSD1 DNAJC25 HSDL2 MIR4668 | |
GH09J111940 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 0.4 | +9.0 | 9047 | 0.8 | ZC3H11A RXRA | RNU6-710P GNG10 SHOC1 HSALNG0073734 MIR4668 UGCG SUSD1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075E82F_9606 | precursor_RNA | 70 | 4 |
RefSeq: NR_039814, Ensembl: ENST00000582284 (view in UCSC) , miRBase: MI0017298, |
URS0000065FDF_9606 | miRNA | 23 | 3 |
RefSeq: NR_039814, miRBase: MIMAT0019746, |
URS00000A17E7_9606 | miRNA | 23 | 3 |
RefSeq: NR_039814, miRBase: MIMAT0019745, ENA: FR772916.1:1..23:ncRNA, LM382547.1:1..23:ncRNA, LM611378.1:1..23:ncRNA, |
No disorders were found for MIR4668 Gene.