microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR466 Gene

Subcategory (RNA class) for MIR466 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR466 Gene

  • MicroRNA 466 2 3 5
  • MIMAT0015002 51
  • Hsa-Mir-466 3
  • Hsa-MiR-466 177
  • MI0014157 51
  • MIR466 2

External Ids for MIR466 Gene

Previous GeneCards Identifiers for MIR466 Gene

  • GC03U901632
  • GC03M031206

Summaries for MIR466 Gene

Entrez Gene Summary for MIR466 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR466 Gene

MIR466 (MicroRNA 466) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR466 include Adhesions Of Uterus.

Additional gene information for MIR466 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR466 Gene

Genomics for MIR466 Gene

GeneHancer (GH) Regulatory Elements for MIR466 Gene

Promoters and enhancers for MIR466 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J031165 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.7 -4.3 -4314 3.4 EP300 ZSCAN5C ZNF639 ZNF10 ZIC2 TRIM28 ATF2 ZNF341 OSR2 BCL11A STT3B MIR466 CNN2P6
GH03J031158 Enhancer 0.5 Ensembl 0.7 +3.5 3486 0.6 ZSCAN5C ZBTB17 PBX2 JUND FEZF1 HNF4A PRDM4 INSM2 ZBTB44 TSHZ1 STT3B MIR466 lnc-STT3B-4
GH03J031170 Enhancer 0.7 Ensembl ENCODE 0.4 -9.9 -9907 3.2 USF1 EZH2 BATF IRF4 STAT1 USF2 HLF MAX IKZF1 IKZF2 ENSG00000236732 MIR466 CNN2P6
GH03J031178 Enhancer 0.3 Ensembl 0.4 -16.6 -16614 0.4 CEBPG CEBPB CNN2P6 MIR466
GH03J031168 Enhancer 0.2 Ensembl 0.4 -6.7 -6714 0.2 MIR466 CNN2P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR466 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR466 Gene

Genomic Locations for MIR466 Gene
chr3:31,161,704-31,161,787
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr3:31,203,196-31,203,279
(GRCh37/hg19)
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR466 Gene

Genes around MIR466 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR466 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR466 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR466 Gene

Proteins for MIR466 Gene

Post-translational modifications for MIR466 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR466 Gene

Domains & Families for MIR466 Gene

Gene Families for MIR466 Gene

HGNC:
genes like me logo Genes that share domains with MIR466: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR466 Gene

Function for MIR466 Gene

Phenotypes From GWAS Catalog for MIR466 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR466 Gene

Localization for MIR466 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR466 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR466 Gene

Pathways & Interactions for MIR466 Gene

PathCards logo

SuperPathways for MIR466 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR466 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR466 Gene

Drugs & Compounds for MIR466 Gene

No Compound Related Data Available

Transcripts for MIR466 Gene

mRNA/cDNA for MIR466 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
4 ENA transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR466 Gene

No ASD Table

Relevant External Links for MIR466 Gene

GeneLoc Exon Structure for
MIR466

Expression for MIR466 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR466 Gene

Orthologs for MIR466 Gene

Evolution for MIR466 Gene

ENSEMBL:
Gene Tree for MIR466 (if available)
TreeFam:
Gene Tree for MIR466 (if available)

No data available for Orthologs for MIR466 Gene

Paralogs for MIR466 Gene

No data available for Paralogs for MIR466 Gene

Variants for MIR466 Gene

Additional dbSNP identifiers (rs#s) for MIR466 Gene

Additional Variant Information for MIR466 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR466

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR466 Gene

Disorders for MIR466 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR466 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adhesions of uterus
  • band of uterus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR466

genes like me logo Genes that share disorders with MIR466: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR466 Gene

Publications for MIR466 Gene

  1. MicroRNA‑466 inhibits cell proliferation and invasion in osteosarcoma by directly targeting insulin receptor substrate 1. (PMID: 30816452) Sun Y … Chen J (Molecular medicine reports 2019) 3 54
  2. miR-466 and NUS1 Regulate the AKT/Nuclear Factor kappa B (NFκB) Signaling Pathway in Intrauterine Adhesions in a Rat Model. (PMID: 31154456) Liu M … Rong F (Medical science monitor : international medical journal of experimental and clinical research 2019) 3 54
  3. LncRNA TUC338 is overexpressed in prostate carcinoma and downregulates miR-466. (PMID: 31085276) Li G … Pu R (Gene 2019) 3 54
  4. MicroRNA‑466 inhibits the aggressive behaviors of hepatocellular carcinoma by directly targeting metadherin. (PMID: 30542714) Jia C … Wu D (Oncology reports 2018) 3 54
  5. MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). (PMID: 29338680) Tong F … Zhan X (Bosnian journal of basic medical sciences 2018) 3 54

Products for MIR466 Gene

Sources for MIR466 Gene