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Aliases for MIR4659B Gene

Subcategory (RNA class) for MIR4659B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4659B Gene

  • MicroRNA 4659b 2 3 5
  • Hsa-Mir-4659b 3

External Ids for MIR4659B Gene

Previous GeneCards Identifiers for MIR4659B Gene

  • GC08U901560
  • GC08P006606
  • GC08M006606

Summaries for MIR4659B Gene

Entrez Gene Summary for MIR4659B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4659B Gene

MIR4659B (MicroRNA 4659b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4659B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4659B Gene

Genomics for MIR4659B Gene

GeneHancer (GH) Regulatory Elements for MIR4659B Gene

Promoters and enhancers for MIR4659B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I006744 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.8 -2.6 -2599 7.2 HDGF FOXA2 SMAD1 ARNT SIN3A YBX1 IRF4 ZNF766 ZNF207 ZNF143 AGPAT5 MCPH1-AS1 ANGPT2 OR7E154P MIR4659A MIR4659B PIR35931
GH08I006777 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.3 -33.5 -33471 2.3 CTCF IRF4 RAD21 RFX5 CC2D1A ARID2 SMC3 ZNF143 BCLAF1 RUNX3 AGPAT5 MCPH1-AS1 ANGPT2 PIR35931 MIR4659B
GH08I006767 Enhancer 0.8 ENCODE 0.3 -22.6 -22609 0.8 HDAC1 ARNT ZBTB40 POLR2B SCRT2 ATF7 RUNX3 CREM ZBTB2 ZNF592 MIR4659B PIR35931
GH08I006787 Enhancer 0.8 ENCODE 0.3 -42.8 -42795 0.2 FEZF1 ZIC2 ZNF2 ZNF121 ZFHX2 GLIS2 ZNF366 POLR2A PATZ1 ZSCAN5C ANGPT2 MCPH1-AS1 AGPAT5 PIR35931 MIR4659B
GH08I006772 Enhancer 0.7 Ensembl ENCODE 0.3 -28.6 -28610 2.7 ZFHX2 ZNF449 GLIS1 ZBTB33 ZIC2 AGPAT5 PIR35931 MIR4659B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4659B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4659B Gene

Genomic Locations for MIR4659B Gene
chr8:6,745,168-6,745,240
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand
chr8:6,602,689-6,602,761
(GRCh37/hg19)

Genomic View for MIR4659B Gene

Genes around MIR4659B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4659B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4659B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4659B Gene

ORGUL Member Location for MIR4659B Gene

ORGUL Member Location for MIR4659B gene

Proteins for MIR4659B Gene

Post-translational modifications for MIR4659B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4659B Gene

Domains & Families for MIR4659B Gene

Gene Families for MIR4659B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4659B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4659B Gene

Function for MIR4659B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4659B Gene

Localization for MIR4659B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4659B Gene

Pathways & Interactions for MIR4659B Gene

SuperPathways for MIR4659B Gene

No Data Available

Interacting Proteins for MIR4659B Gene

Gene Ontology (GO) - Biological Process for MIR4659B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4659B Gene

Drugs & Compounds for MIR4659B Gene

No Compound Related Data Available

Transcripts for MIR4659B Gene

mRNA/cDNA for MIR4659B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4659B Gene

No ASD Table

Relevant External Links for MIR4659B Gene

GeneLoc Exon Structure for
MIR4659B
ECgene alternative splicing isoforms for
MIR4659B

Expression for MIR4659B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4659B Gene:

MIR4659B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4659B Gene

Orthologs for MIR4659B Gene

Evolution for MIR4659B Gene

ENSEMBL:
Gene Tree for MIR4659B (if available)
TreeFam:
Gene Tree for MIR4659B (if available)

No data available for Orthologs for MIR4659B Gene

Paralogs for MIR4659B Gene

No data available for Paralogs for MIR4659B Gene

Variants for MIR4659B Gene

Sequence variations from dbSNP and Humsavar for MIR4659B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1001511986 -- 6,745,916(-) T/C upstream_transcript_variant
rs1001550387 -- 6,747,041(-) T/C upstream_transcript_variant
rs1001746547 -- 6,746,908(-) C/G upstream_transcript_variant
rs1003193687 -- 6,744,890(-) C/G downstream_transcript_variant
rs1003222845 -- 6,746,229(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4659B Gene

Variant ID Type Subtype PubMed ID
dgv6876n100 CNV loss 25217958
dgv6877n100 CNV gain 25217958
dgv6878n100 CNV gain 25217958
esv2422383 CNV duplication 17116639
nsv1021684 CNV loss 25217958
nsv1025976 CNV loss 25217958
nsv831220 CNV gain 17160897
nsv610006 CNV gain 21841781
nsv610004 CNV gain 21841781
nsv465436 CNV gain 19166990
nsv1031577 CNV gain 25217958

Additional Variant Information for MIR4659B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4659B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4659B Gene

Disorders for MIR4659B Gene

Additional Disease Information for MIR4659B

No disorders were found for MIR4659B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4659B Gene

Publications for MIR4659B Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4659B Gene

Sources for MIR4659B Gene

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