Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4656 Gene

Subcategory (RNA class) for MIR4656 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4656 Gene

  • MicroRNA 4656 2 3 5
  • Hsa-Mir-4656 3

External Ids for MIR4656 Gene

Previous GeneCards Identifiers for MIR4656 Gene

  • GC07U903202
  • GC07M004830
  • GC07M004831
  • GC07M004833

Summaries for MIR4656 Gene

Entrez Gene Summary for MIR4656 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4656 Gene

MIR4656 (MicroRNA 4656) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4656 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4656 Gene

Genomics for MIR4656 Gene

GeneHancer (GH) Regulatory Elements for MIR4656 Gene

Promoters and enhancers for MIR4656 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I004791 Enhancer 0.8 Ensembl ENCODE 0.8 -3.6 -3560 2.3 CTCF MXI1 MAX BACH1 SIN3A ZNF148 POLR2A ZNF143 ZBTB33 CREM AP5Z1 RADIL MIR4656 GC07P004785 GC07P004807
GH07I004798 Enhancer 0.9 Ensembl ENCODE 0.4 -9.8 -9762 0.4 HDGF CTCF RB1 MAX RAD21 SMC3 ZNF143 ZNF444 CREM CHD2 AP5Z1 GC07P004807 MIR4656 RADIL
GH07I004794 Enhancer 0.5 ENCODE 0.4 -6.1 -6116 0.9 ATF4 STAT1 NFYC FOS ZBTB33 AP5Z1 MIR4656 GC07P004807
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4656 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4656 Gene

Genomic Locations for MIR4656 Gene
chr7:4,788,565-4,788,639
(GRCh38/hg38)
Size:
75 bases
Orientation:
Minus strand
chr7:4,828,196-4,828,270
(GRCh37/hg19)

Genomic View for MIR4656 Gene

Genes around MIR4656 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4656 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4656 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4656 Gene

ORGUL Member Location for MIR4656 Gene

ORGUL Member Location for MIR4656 gene

Proteins for MIR4656 Gene

Post-translational modifications for MIR4656 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4656 Gene

Domains & Families for MIR4656 Gene

Gene Families for MIR4656 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4656: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4656 Gene

Function for MIR4656 Gene

Phenotypes From GWAS Catalog for MIR4656 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4656 Gene

Localization for MIR4656 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4656 Gene

Pathways & Interactions for MIR4656 Gene

SuperPathways for MIR4656 Gene

No Data Available

Interacting Proteins for MIR4656 Gene

Gene Ontology (GO) - Biological Process for MIR4656 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4656 Gene

Drugs & Compounds for MIR4656 Gene

No Compound Related Data Available

Transcripts for MIR4656 Gene

mRNA/cDNA for MIR4656 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4656 Gene

No ASD Table

Relevant External Links for MIR4656 Gene

GeneLoc Exon Structure for
MIR4656
ECgene alternative splicing isoforms for
MIR4656

Expression for MIR4656 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4656 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4656 Gene:

MIR4656
genes like me logo Genes that share expression patterns with MIR4656: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4656 Gene

Orthologs for MIR4656 Gene

Evolution for MIR4656 Gene

ENSEMBL:
Gene Tree for MIR4656 (if available)
TreeFam:
Gene Tree for MIR4656 (if available)

No data available for Orthologs for MIR4656 Gene

Paralogs for MIR4656 Gene

No data available for Paralogs for MIR4656 Gene

Variants for MIR4656 Gene

Sequence variations from dbSNP and Humsavar for MIR4656 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1057519342 pathogenic, Spastic paraplegia 48, autosomal recessive 4,789,856(-) C/T upstream_transcript_variant
rs118139547 likely-benign, Spastic Paraplegia, Recessive 4,789,818(-) C/T upstream_transcript_variant
rs141607676 uncertain-significance, Spastic paraplegia 48, autosomal recessive 4,788,298(-) C/T downstream_transcript_variant
rs182411153 benign, Spastic paraplegia 48, autosomal recessive 4,788,262(-) G/A downstream_transcript_variant
rs184752711 uncertain-significance, benign, Spastic Paraplegia, Recessive, Spastic paraplegia 48, autosomal recessive 4,789,827(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4656 Gene

Variant ID Type Subtype PubMed ID
esv2664593 CNV deletion 23128226
esv3611949 CNV loss 21293372
nsv1029123 CNV loss 25217958
nsv471293 CNV loss 18288195
nsv482101 CNV gain 20164927
nsv528748 CNV loss 19592680
nsv5626 CNV insertion 18451855
nsv605977 CNV loss 21841781
nsv605978 CNV gain 21841781
nsv8033 CNV loss 18304495
nsv823994 CNV gain 20364138
nsv950797 CNV deletion 24416366

Additional Variant Information for MIR4656 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4656

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4656 Gene

Disorders for MIR4656 Gene

Additional Disease Information for MIR4656

No disorders were found for MIR4656 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4656 Gene

Publications for MIR4656 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4656 Gene

Sources for MIR4656 Gene

Content
Loading form....