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Aliases for MIR4643 Gene

Subcategory (RNA class) for MIR4643 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4643 Gene

  • MicroRNA 4643 2 3 5
  • Hsa-Mir-4643 3

External Ids for MIR4643 Gene

Previous GeneCards Identifiers for MIR4643 Gene

  • GC06U902220
  • GC06P092233

Summaries for MIR4643 Gene

Entrez Gene Summary for MIR4643 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4643 Gene

MIR4643 (MicroRNA 4643) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4643 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4643 Gene

Genomics for MIR4643 Gene

GeneHancer (GH) Regulatory Elements for MIR4643 Gene

Promoters and enhancers for MIR4643 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I091481 Enhancer 0.8 ENCODE 0.3 -38.7 -38741 2.2 PKNOX1 JUN BACH1 EBF1 BMI1 BATF KLF5 IRF4 RELA ATF7 GC06M091419 MIR4643
GH06I091475 Enhancer 0.9 Ensembl ENCODE 0.2 -45.5 -45470 0.5 PKNOX1 USF1 MAX BACH1 FEZF1 GATA3 ZNF316 ATF7 PRDM10 NFE2 GC06M091419 MIR4643
GH06I091572 Enhancer 0.4 UCNEbase 0.2 +51.5 51452 0.4 MIR4643 GC06P091655
GH06I091633 Enhancer 0.5 ENCODE 0.1 +112.0 112011 0.1 HDGF TARDBP ZSCAN4 NBN MLLT1 GC06P091655 CASC6 MIR4643
GH06I091653 Enhancer 0.5 ENCODE 0.1 +132.8 132828 1.2 SCRT1 POLR2A SIN3A HNF4A REST RAD21 YY1 GC06P091655 CASC6 MIR4643
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4643 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4643 Gene

Genomic Locations for MIR4643 Gene
chr6:91,521,660-91,521,737
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand
chr6:92,231,378-92,231,455
(GRCh37/hg19)

Genomic View for MIR4643 Gene

Genes around MIR4643 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4643 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4643 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4643 Gene

Proteins for MIR4643 Gene

Post-translational modifications for MIR4643 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4643 Gene

Domains & Families for MIR4643 Gene

Gene Families for MIR4643 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4643: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4643 Gene

Function for MIR4643 Gene

Phenotypes From GWAS Catalog for MIR4643 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4643 Gene

Localization for MIR4643 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4643 Gene

Pathways & Interactions for MIR4643 Gene

SuperPathways for MIR4643 Gene

No Data Available

Interacting Proteins for MIR4643 Gene

Gene Ontology (GO) - Biological Process for MIR4643 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4643 Gene

Drugs & Compounds for MIR4643 Gene

No Compound Related Data Available

Transcripts for MIR4643 Gene

mRNA/cDNA for MIR4643 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4643 Gene

No ASD Table

Relevant External Links for MIR4643 Gene

GeneLoc Exon Structure for
MIR4643
ECgene alternative splicing isoforms for
MIR4643

Expression for MIR4643 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4643 Gene:

MIR4643
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4643 Gene

Orthologs for MIR4643 Gene

Evolution for MIR4643 Gene

ENSEMBL:
Gene Tree for MIR4643 (if available)
TreeFam:
Gene Tree for MIR4643 (if available)

No data available for Orthologs for MIR4643 Gene

Paralogs for MIR4643 Gene

No data available for Paralogs for MIR4643 Gene

Variants for MIR4643 Gene

Sequence variations from dbSNP and Humsavar for MIR4643 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001052409 -- 91,521,908(+) T/C downstream_transcript_variant
rs1001224841 -- 91,521,255(+) T/C upstream_transcript_variant
rs1002271693 -- 91,521,508(+) T/C upstream_transcript_variant
rs1002661012 -- 91,520,223(+) C/T upstream_transcript_variant
rs1002847194 -- 91,519,795(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4643 Gene

Variant ID Type Subtype PubMed ID
nsv1023081 CNV gain 25217958

Additional Variant Information for MIR4643 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4643

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4643 Gene

Disorders for MIR4643 Gene

Additional Disease Information for MIR4643

No disorders were found for MIR4643 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4643 Gene

Publications for MIR4643 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4643 Gene

Sources for MIR4643 Gene

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