microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4634 Gene

Subcategory (RNA class) for MIR4634 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR4634 Gene

  • MicroRNA 4634 2 3 5
  • Hsa-Mir-4634 3
  • MIMAT0019691 53
  • MI0017261 53
  • MIR4634 2

External Ids for MIR4634 Gene

Previous GeneCards Identifiers for MIR4634 Gene

  • GC05U901579
  • GC05P174181

Summaries for MIR4634 Gene

Entrez Gene Summary for MIR4634 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4634 Gene

MIR4634 (MicroRNA 4634) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4634 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4634 Gene

Genomics for MIR4634 Gene

GeneHancer (GH) Regulatory Elements for MIR4634 Gene

Promoters and enhancers for MIR4634 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J174751 Promoter 1.2 Ensembl CraniofacialAtlas 750.6 -0.2 -235 1.4 ZNF362 ZNF384 SP7 GLIS2 ZIC2 ZBTB8A PRDM10 ZEB2 POLR2A PATZ1 ENSG00000251670 MIR4634 MSX2
GH05J174767 Enhancer 0.3 FANTOM5 0.4 +15.8 15790 0.3 ZFHX2 MSX2 piR-43107-253 ENSG00000251670 MIR4634
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4634 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4634 Gene

Genomic Locations for MIR4634 Gene
chr5:174,751,734-174,751,787
(GRCh38/hg38)
Size:
54 bases
Orientation:
Plus strand
chr5:174,178,737-174,178,790
(GRCh37/hg19)
Size:
54 bases
Orientation:
Plus strand

Genomic View for MIR4634 Gene

Genes around MIR4634 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4634 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4634 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4634 Gene

Proteins for MIR4634 Gene

Post-translational modifications for MIR4634 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4634 Gene

Domains & Families for MIR4634 Gene

Gene Families for MIR4634 Gene

HGNC:
genes like me logo Genes that share domains with MIR4634: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4634 Gene

Function for MIR4634 Gene

Phenotypes From GWAS Catalog for MIR4634 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4634 Gene

Localization for MIR4634 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4634 Gene

Pathways & Interactions for MIR4634 Gene

PathCards logo

SuperPathways for MIR4634 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4634 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4634 Gene

Drugs & Compounds for MIR4634 Gene

No Compound Related Data Available

Transcripts for MIR4634 Gene

mRNA/cDNA for MIR4634 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(1) ENA transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4634 Gene

No ASD Table

Relevant External Links for MIR4634 Gene

GeneLoc Exon Structure for
MIR4634
ECgene alternative splicing isoforms for
MIR4634

Expression for MIR4634 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4634 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4634 Gene:

MIR4634
genes like me logo Genes that share expression patterns with MIR4634: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4634 Gene

Orthologs for MIR4634 Gene

Evolution for MIR4634 Gene

ENSEMBL:
Gene Tree for MIR4634 (if available)
TreeFam:
Gene Tree for MIR4634 (if available)

No data available for Orthologs for MIR4634 Gene

Paralogs for MIR4634 Gene

No data available for Paralogs for MIR4634 Gene

Variants for MIR4634 Gene

Sequence variations from dbSNP and Humsavar for MIR4634 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000262594 -- 174,751,667(+) G/C upstream_transcript_variant
rs1000592086 -- 174,751,804(+) C/G downstream_transcript_variant
rs1000633200 -- 174,750,716(+) T/C/G upstream_transcript_variant
rs1000984198 -- 174,750,379(+) G/A upstream_transcript_variant
rs1001473612 -- 174,750,589(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4634 Gene

Variant ID Type Subtype PubMed ID
esv3607637 CNV gain 21293372
nsv5139 CNV insertion 18451855
nsv600327 CNV loss 21841781

Additional Variant Information for MIR4634 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4634

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4634 Gene

Disorders for MIR4634 Gene

Additional Disease Information for MIR4634

No disorders were found for MIR4634 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4634 Gene

Publications for MIR4634 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR4634 Gene

Sources for MIR4634 Gene