microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR454 Gene

Subcategory (RNA class) for MIR454 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR454 Gene

  • MicroRNA 454 2 3 5
  • Hsa-MiR-454-5p 163 173
  • Hsa-MiR-454-3p 163 173
  • Hsa-Mir-454 2 3
  • MIR454 2 5
  • Hsa-Mir-130-P4a 178
  • MIMAT0003884 50
  • MIMAT0003885 50
  • MI0003820 50
  • MIRN454 3
  • Mir-454 3
  • RF00746 168

External Ids for MIR454 Gene

Previous HGNC Symbols for MIR454 Gene

  • MIRN454

Previous GeneCards Identifiers for MIR454 Gene

  • GC17M054570
  • GC17M057215

Summaries for MIR454 Gene

Entrez Gene Summary for MIR454 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR454 Gene

MIR454 (MicroRNA 454) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR454 include Colorectal Cancer and Prediabetes Syndrome.

Rfam classification for MIR454 Gene

Additional gene information for MIR454 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR454 Gene

Genomics for MIR454 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR454 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J059138 Enhancer 0.6 Ensembl 600.7 -1.1 -1129 1.2 CEBPG ZBTB33 RFX1 CEBPA BMI1 CTBP1 HCFC1 NONO DPF2 ZNF579 MIR454 MIR301A SKA2 lnc-TRIM37-1-001 TRIM37
GH17J059209 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10 -72.6 -72629 3 ARHGAP35 CEBPG SP1 CREB1 GATAD2A ZBTB33 YBX1 PRDM10 REST ZNF629 SMG8 TUBD1 RPS6KB1 MKS1 TRIM37 SKA2 HEATR6 DHX40 TSPOAP1 RNFT1
GH17J059219 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10 -83.1 -83087 2.5 CEBPG CREB1 CTCF ZBTB33 PRDM10 ZNF629 TFE3 RFX1 NFKBIZ KDM1A GDPD1 TUBD1 RPS6KB1 RAD51C DHX40 HEATR6 MIR454 SKA2 piR-42491-097 YPEL2
GH17J059092 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 +43.5 43503 3.5 PRDM10 ZNF629 PRDM1 RELA MTA1 PATZ1 ZNF501 ZNF600 SCRT2 ZBTB44 RAD51C MIR454 SMG8 TEX14 RF00017-2472 TRIM37 lnc-SKA2-3 lnc-SKA2-4 PPM1E
GH17J059440 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.4 -302.5 -302518 3 CREB1 GATAD2A CTCF NFKBIZ FOXA1 RELA RXRB REST RAD21 IRF2 YPEL2 SMG8 MIR454 HSALNG0117773 piR-57134-049 LINC01476 DHX40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR454 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR454 Gene

Genomic Locations for MIR454 Gene
chr17:59,137,758-59,137,872
(GRCh38/hg38)
Size:
115 bases
Orientation:
Minus strand
chr17:57,215,119-57,215,233
(GRCh37/hg19)
Size:
115 bases
Orientation:
Minus strand

Genomic View for MIR454 Gene

Genes around MIR454 on UCSC Golden Path with GeneCards custom track
MIR454 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR454 Gene

Proteins for MIR454 Gene

Post-translational modifications for MIR454 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR454 Gene

Domains & Families for MIR454 Gene

Gene Families for MIR454 Gene

genes like me logo Genes that share domains with MIR454: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR454 Gene

Function for MIR454 Gene

Phenotypes From GWAS Catalog for MIR454 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR454 Gene

Localization for MIR454 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR454 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR454: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR454 Gene

Pathways & Interactions for MIR454 Gene

PathCards logo

SuperPathways for MIR454 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR454 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR454: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR454 Gene

Drugs & Compounds for MIR454 Gene

No Compound Related Data Available

Transcripts for MIR454 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR454 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000070F95C_9606 precursor_RNA 115 6

HGNC: 33137,

RefSeq: NR_030411,

Ensembl: ENST00000390180 (view in UCSC) ,

miRBase: MI0003820,

Rfam: RF00746,

ENA: LM609631.1:1..115:precursor_RNA,

URS00004F77ED_9606 miRNA 23 5

RefSeq: NR_030411,

LncBase: hsa-miR-454-3p,

miRBase: MIMAT0003885,

TarBase: hsa-miR-454-3p,

ENA: LM380029.1:1..23:ncRNA, LM609631.1:64..86:ncRNA,

URS000031602A_9606 miRNA 22 5

RefSeq: NR_030411,

LncBase: hsa-miR-454-5p,

miRBase: MIMAT0003884,

TarBase: hsa-miR-454-5p,

ENA: LM380028.1:1..22:ncRNA, LM609631.1:24..45:ncRNA,

URS0000EFF386_9606 precursor_RNA 66 1

MirGeneDB: Hsa-Mir-130-P4a,

URS0000D510F1_9606 miRNA 25 1

MirGeneDB: Hsa-Mir-130-P4a_3p,

MIR454 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR454 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR454 Gene

No ASD Table

Relevant External Links for MIR454 Gene

GeneLoc Exon Structure for
MIR454

Expression for MIR454 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR454 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR454

genes like me logo Genes that share expression patterns with MIR454: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR454 Gene

Orthologs for MIR454 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR454 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-454 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-454 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-454 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-454 31
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-454 31
  • 51 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-454 31
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-454a 31
  • 61 (a)
OneToOne
Species where no ortholog for MIR454 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR454 Gene

ENSEMBL:
Gene Tree for MIR454 (if available)
TreeFam:
Gene Tree for MIR454 (if available)

Paralogs for MIR454 Gene

No data available for Paralogs for MIR454 Gene

Variants for MIR454 Gene

Additional dbSNP identifiers (rs#s) for MIR454 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR454 Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv3271n100 CNV gain 25217958
esv2758699 CNV gain 17122850
esv990139 CNV deletion 20482838
nsv1065063 CNV gain 25217958
nsv575802 CNV loss 21841781
nsv833499 CNV loss 17160897

Additional Variant Information for MIR454 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR454

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR454 Gene

Disorders for MIR454 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR454 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
prediabetes syndrome
  • prediabetes
esophageal disease
  • esophageal ulcer
cervix disease
  • cervix disorders
lung cancer susceptibility 3
  • lncr3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR454

genes like me logo Genes that share disorders with MIR454: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR454 Gene

Publications for MIR454 Gene

  1. MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia. (PMID: 30367833) Shi Z … Wang Y (Chemico-biological interactions 2019) 3
  2. Downregulation of Calbindin 1 by miR-454-3p Suppresses Cell Proliferation in Nonsmall Cell Lung Cancer In Vitro. (PMID: 30638403) Jin C … Shan L (Cancer biotherapy & radiopharmaceuticals 2019) 3
  3. miR-454-3p Is an Exosomal Biomarker and Functions as a Tumor Suppressor in Glioma. (PMID: 30413650) Shao N … Lan Q (Molecular cancer therapeutics 2019) 3
  4. Long Chain Non-Coding RNA (lncRNA) HOTAIR Knockdown Increases miR-454-3p to Suppress Gastric Cancer Growth by Targeting STAT3/Cyclin D1. (PMID: 30810117) Jiang D … Xiong M (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  5. miR-454-3p exerts tumor-suppressive functions by down-regulation of NFATc2 in glioblastoma. (PMID: 31181312) Zuo J … Ni H (Gene 2019) 3

Products for MIR454 Gene

Sources for MIR454 Gene